Abstract: The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain H-APPAMP compounds (referred to herein as “H-APPAMP compounds”) that, inter alia, inhibit cyclin-dependent protein kinases (CDKs), especially CDK12 and/or CDK13, and are selective, for example, for CDK12 and/or CDK13 as compared to CDK7. In addition to selectively inhibiting CDK12 and/or CDK13, the compounds also act as selective Cyclin K degraders thereby removing the key signaling mechanism required for CDK12 and/or CDK13 activation; this confers additional cellular potency and selectivity.

Abstract: This invention relates to compounds that are useful as cancer therapies. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to methods of using said compounds and to pharmaceutical formulations comprising said compounds.

Abstract: The present invention relates to certain 4-(substituted aniline)-2-(substituted piperidin-1-yl)pyrimidine-5-carboxamide compounds which may be useful in the treatment or prevention of a disease or medical condition mediated through signaling of CaMK1 isoforms. For example, such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers, metabolic diseases including type-2 diabetes, and/or immune-mediated disorders.

Abstract: This invention relates to compounds that are useful as cancer therapies. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to methods of using said compounds and the pharmaceutical formulations comprising said compounds.

Abstract: This invention relates to compounds that are useful as cancer therapies. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to methods of using said compounds and the pharmaceutical formulations comprising said compounds.

Abstract: This invention relates to compounds that are useful as cancer therapies. The compounds comprise derivatives of tetracycline antibiotics, e.g. doxycycline, having a phosphonium cation tethered to the tetracycline tetracycle. The invention also relates to methods of using said compounds and to pharmaceutical formulations comprising said compounds.

Abstract: The present invention relates to certain 4-(substituted aniline)-2-(substituted piperidin-1-yl)pyrimidine-carboxamide compounds which may be useful in the treatment or prevention of a disease or medical condition mediated through signalling of CaMK1 isoforms. For example, such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers, metabolic diseases including type-2 diabetes, and/or immune-mediated disorders.

Abstract: This invention relates to compounds that are useful as cancer therapies. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to methods of using said compounds and to pharmaceutical formulations comprising said compounds.

Abstract: This invention relates to compounds that are useful as cancer therapies. The compounds comprise derivatives of tetracycline antibiotics, e.g. doxycycline, having a phosphonium cation tethered to the tetracycline tetracycle. The invention also relates to methods of using said compounds and to pharmaceutical formulations comprising said compounds.

Abstract: This invention relates to compounds that are useful as cancer therapies. The compounds comprise azithromycin derivatives having a phosphonium cation tethered to the azithromycin macrocycle. The invention also relates to methods of using said compounds and the pharmaceutical formulations comprising said compounds.

Abstract: This invention relates to compounds that are useful as cancer therapies. The compounds comprise derivatives of tetracycline antibiotics, e.g. doxycycline, having a phosphonium cation tethered to the tetracycline tetracycle. The invention also relates to methods of using said compounds and to pharmaceutical formulations comprising said compounds.

Abstract: This invention relates to compounds that are useful as cancer therapies. The compounds comprise derivatives of tetracycline antibiotics, e.g. doxycycline, having a phosphonium cation tethered to the tetracycline tetracycle. The invention also relates to methods of using said compounds and to pharmaceutical formulations comprising said compounds.

Abstract: A tobacco mass is heated to a temperature of about 150° to about 220° C. to release flavorful tobacco volatiles, which are entrained in air passing through the tobacco mass, and condensed to form an inhalable aerosol. The tobacco mass may have a rotationally symmetric shape, with at least part of its surface in heat transfer relationship with a heater. The heater may be an external shell, an internal rod, or a plate. A shell can enclose the heater and tobacco mass and define a preheating chamber for inflowing air. A mouthpiece, with or without a filter, may be arranged in fluid communication with the tobacco mass to direct the aerosol from the heating system.

Abstract: A brush cleaning unit for a heater fixture of a smoking device includes a holder such as a tube wherein the heater fixture can be washed with a liquid by a movable brush. The tube can include first and second ends, a portion of a key for cooperating with a corresponding portion of the key on the heater fixture for orienting the heater fixture, and an arrangement for preventing the brush from rotating. The brush can be arranged to be axially movable relative to the tube and the heater fixture attached thereto.

Abstract: A brush cleaning unit for a heater fixture of a smoking device includes a tube having a first end and a second end, the tube including a portion of a key for cooperating with a corresponding portion of the key on a heater fixture for attaching and orienting the heater fixture relative to the tube. The brush cleaning unit also includes a brush attached to the tube. The brush is axially movable relative to the tube and the heater fixture attached thereto. The brush is non-rotatable relative to the tube. A method for cleaning a heater fixture is also disclosed.