Abstract: A hydraulic pumping system in accordance with embodiments comprises a breast interface operably coupled to an actuatable assembly by means of an actuatable assembly interface. The breast interface comprises a distal membrane coupled to a housing to form a fluid reservoir therebetween. The actuatable assembly interface comprises a proximal membrane. The distal and proximal membranes are fluidly coupled via a tube carrying a driving fluid. The actuatable assembly interface is configured to removably couple to the actuatable assembly, in order to operably couple the actuatable assembly to the breast interface. The actuatable assembly interface comprises a fluid shut off mechanism to reversibly shut off fluid communication between the breast interface and the actuatable assembly interface when the actuatable assembly interface is decoupled from the actuatable assembly.

Abstract: A hydraulic pumping system in accordance with embodiments comprises a breast interface operably coupled to an actuatable assembly by means of an actuatable assembly interface. The breast interface comprises a distal membrane coupled to a housing to form a fluid reservoir therebetween. The actuatable assembly interface comprises a proximal membrane. The distal and proximal membranes are fluidly coupled via a tube carrying a driving fluid. The actuatable assembly interface is configured to removably couple to the actuatable assembly, in order to operably couple the actuatable assembly to the breast interface. The actuatable assembly interface comprises a fluid shut off mechanism to reversibly shut off fluid communication between the breast interface and the actuatable assembly interface when the actuatable assembly interface is decoupled from the actuatable assembly.

Abstract: A hydraulic pumping system in accordance with embodiments comprises a breast interface operably coupled to an actuatable assembly by means of an actuatable assembly interface. The breast interface comprises a distal membrane coupled to a housing to form a fluid reservoir therebetween. The actuatable assembly interface comprises a proximal membrane. The distal and proximal membranes are fluidly coupled via a tube carrying a driving fluid. The actuatable assembly interface is configured to removably couple to the actuatable assembly, in order to operably couple the actuatable assembly to the breast interface. The actuatable assembly interface comprises a fluid shut off mechanism to reversibly shut off fluid communication between the breast interface and the actuatable assembly interface when the actuatable assembly interface is decoupled from the actuatable assembly.

Abstract: A hydraulic pumping system in accordance with embodiments comprises a breast interface operably coupled to an actuatable assembly by means of an actuatable assembly interface. The breast interface comprises a distal membrane coupled to a housing to form a fluid reservoir therebetween. The actuatable assembly interface comprises a proximal membrane. The distal and proximal membranes are fluidly coupled via a tube carrying a driving fluid. The actuatable assembly interface is configured to removably couple to the actuatable assembly, in order to operably couple the actuatable assembly to the breast interface. The actuatable assembly interface comprises a fluid shut off mechanism to reversibly shut off fluid communication between the breast interface and the actuatable assembly interface when the actuatable assembly interface is decoupled from the actuatable assembly.

Abstract: A hydraulic pumping system in accordance with embodiments comprises a breast interface operably coupled to an actuatable assembly by means of an actuatable assembly interface. The breast interface comprises a distal membrane coupled to a housing to form a fluid reservoir therebetween. The actuatable assembly interface comprises a proximal membrane. The distal and proximal membranes are fluidly coupled via a tube carrying a driving fluid. The actuatable assembly interface is configured to removably couple to the actuatable assembly, in order to operably couple the actuatable assembly to the breast interface. The actuatable assembly interface comprises a fluid shut off mechanism to reversibly shut off fluid communication between the breast interface and the actuatable assembly interface when the actuatable assembly interface is decoupled from the actuatable assembly.

Abstract: In a method of stapling layers of tissue within a body cavity, an engaging instrument is passed between a stapler cartridge and anvil and used to engage a region of tissue. The engaging instrument is retracted to move the engaged tissue into the stapling position, and driving staples from the cartridge through at least two layers of the engaged tissue. The method and associated system may be used to form plications in body tissue, such as stomach wall tissue. Staples simultaneously driven through tissue may simultaneously capture a reinforcing elements positioned adjacent the cartridge and/or anvil prior to stapling.

Abstract: Endoscopic plicators are passed transorally into the stomach and used to plicate stomach tissue by engaging tissue from inside of the stomach and drawing it inwardly. The tissue is drawn inwardly into a vacuum chamber, causing sections of serosal tissue on the exterior of the stomach to be positioned facing one another. The plicators allow the opposed sections of tissue to be moved into contact with one another, and preferably deliver sutures, staples or other means for maintaining contact between the tissue sections at least until serosal bonds form between them. Each of these steps may be performed wholly from the inside of the stomach and thus can eliminate the need for any surgical or laparscopic intervention. After one or more plications is formed, medical devices may be coupled to the plication(s) for retention within the stomach.

Abstract: A system, device, device and method for implanting a food restrictor in a patient's stomach, by coupling the restrictor to a plurality of tissue-plication anchors already placed in the stomach, are disclosed. The device includes an elongate shaft assembly for accessing the stomach transorally, and on which the restrictor can be carried, and a plurality of cable members mounted on the shaft assembly. The cable members are disposed on the shaft assembly along a distal section thereof, and releasably attached to the shaft assembly's distal end. After a cable member engages a tissue-plication anchor, retracting the cable is operable to first release the member from a holder at the distal end of the shaft assembly, then pull a portion of the anchor through an aperture in the restrictor. This process is repeated for each anchor in the stomach for attaching the restrictor to the stomach.

Abstract: Described herein are endoscopic plicators passed transorally into the stomach and used to plicate stomach tissue by engaging tissue from inside of the stomach and drawing it inwardly. In the disclosed embodiments, the tissue is drawn inwardly into a vacuum chamber, causing sections of serosal tissue on the exterior of the stomach to be positioned facing one another. The disclosed plicators allow the opposed sections of tissue to be moved into contact with one another, and preferably deliver sutures, staples or other means for maintaining contact between the tissue sections at least until serosal bonds form between them. Each of these steps may be performed wholly from the inside of the stomach and thus can eliminate the need for any surgical or laparoscopic intervention. After one or more plications is formed, medical devices may be coupled to the plication(s) for retention within the stomach.

Abstract: A system, device, device and method for implanting a food restrictor in a patient's stomach, by coupling the restrictor to a plurality of tissue-plication anchors already placed in the stomach, are disclosed. The device includes an elongate shaft assembly for accessing the stomach transorally, and on which the restrictor can be carried, and a plurality of cable members mounted on the shaft assembly. The cable members are disposed on the shaft assembly along a distal section thereof, and releasably attached to the shaft assembly's distal end. After a cable member engages a tissue-plication anchor, retracting the cable is operable to first release the member from a holder at the the distal end of the shaft assembly, then pull a portion of the anchor through an aperture in the restrictor. This process is repeated for each anchor in the stomach for attaching the restrictor to the stomach.

Abstract: An improvement in a stapling device and method designed to capture a tissue fold between first and second members in the device and to staple and cut the fold to form a stapled tissue plication with a hole therein is disclosed. The improvement includes an engagement assembly in the first member movable from a retracted position in the first member to an extended position in the second member, and releasably attached to second member, an anchor assembly that includes the anchor, wherein (i) movement of the engagement assembly from its retracted to its extended position, through a tissue fold captured in the device between the first and second device members, is operable to engage the anchor assembly, and (ii) movement of the engagement assembly, with the anchor assembly engaged therewith, back toward its retracted position, is effective to pull at least a portion of the assembly through the hole in the stapled tissue plication formed by the device.

Abstract: Described herein are endoscopic plicators passed transorally into the stomach and used to plicate stomach tissue by engaging tissue from inside of the stomach and drawing it inwardly. In the disclosed embodiments, the tissue is drawn inwardly into a vacuum chamber, causing sections of serosal tissue on the exterior of the stomach to be positioned facing one another. The disclosed plicators allow the opposed sections of tissue to be moved into contact with one another, and preferably deliver sutures, staples or other means for maintaining contact between the tissue sections at least until serosal bonds form between them. Each of these steps may be performed wholly from the inside of the stomach and thus can eliminate the need for any surgical or laparoscopic intervention. After one or more plications is formed, medical devices may be coupled to the plication(s) for retention within the stomach.

Abstract: In a method of stapling layers of tissue within a body cavity, an engaging instrument is passed between a stapler cartridge and anvil and used to engage a region of tissue. The engaging instrument is retracted to move the engaged tissue into the stapling position, and driving staples from the cartridge through at least two layers of the engaged tissue. The method and associated system may be used to form plications in body tissue, such as stomach wall tissue. Staples simultaneously driven through tissue may simultaneously capture a reinforcing elements positioned adjacent the cartridge and/or anvil prior to stapling.

Abstract: Described herein are endoscopic plicators passed transorally into the stomach and used to plicate stomach tissue by engaging tissue from inside of the stomach and drawing it inwardly. In the disclosed embodiments, the tissue is drawn inwardly into a vacuum chamber, causing sections of serosal tissue on the exterior of the stomach to be positioned facing one another. The disclosed plicators allow the opposed sections of tissue to be moved into contact with one another, and preferably deliver sutures, staples or other means for maintaining contact between the tissue sections at least until serosal bonds form between them. Each of these steps may be performed wholly from the inside of the stomach and thus can eliminate the need for any surgical or laparoscopic intervention. After one or more plications is formed, medical devices may be coupled to the plication(s) for retention within the stomach.