Patents by Inventor Brett Tounge

Brett Tounge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Spiropiperidines for use as tryptase inhibitors
    Patent number: 8536189
    Abstract: The present invention is directed to a compound of Formula (I): or a form thereof, wherein X1, X2, X3, X4, R1, R2 and R3 are as defined herein, useful as tryptase inhibitors.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: September 17, 2013
    Assignee: Janssen Pharmaceutica NV
    Inventors: Michael J. Costanzo, Stephen C. Yabut, Brett Tounge, Bruce E. Maryanoff, Han-Cheng Zhang
  • SPIROPIPERIDINES FOR USE AS TRYPTASE INHIBITORS
    Publication number: 20120165327
    Abstract: The present invention is directed to a compound of Formula (I): or a form thereof, wherein X1, X2, X3, X4, R1, R2 and R3 are as defined herein, useful as tryptase inhibitors.
    Type: Application
    Filed: March 1, 2012
    Publication date: June 28, 2012
    Inventors: Michael J. Costanzo, Stephen C. Yabut, Brett Tounge, Bruce E. Maryanoff, Han-Cheng Zhang
  • Spiropiperidines for use as tryptase inhibitors
    Patent number: 8158792
    Abstract: The present invention is directed to a compound of Formula (I): or a form thereof, wherein X1, X2, X3, X4, R1, R2 and R3 are as defined herein, useful as tryptase inhibitors.
    Type: Grant
    Filed: November 19, 2008
    Date of Patent: April 17, 2012
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Michael J. Costanzo, Stephen C. Yabut, Brett Tounge, Bruce E. Maryanoff, Han-Cheng Zhang
  • Collagen-related peptides
    Publication number: 20090299034
    Abstract: The present invention relates to a collagen-related polypeptide (CRP) having hydrophobic amino acid groups at the N- and C-termini capable of non-covalent self-assembly into collagen mimetic triple helices and fibrils thereof and the synthesis, methods of use and compositions thereof.
    Type: Application
    Filed: August 1, 2007
    Publication date: December 3, 2009
    Inventors: Mabel Alamino Cejas, William A. Kinney, Bruce E. Maryanoff, Brett Tounge
  • Spiropiperidines for use as tryptase inhibitors
    Publication number: 20090163527
    Abstract: The present invention is directed to a compound of Formula (I): or a form thereof, wherein X1, X2, X3, X4, R1, R2 and R3 are as defined herein, useful as tryptase inhibitors.
    Type: Application
    Filed: November 19, 2008
    Publication date: June 25, 2009
    Inventors: Michael J. Costanzo, Stephen C. Yabut, Brett Tounge, Bruce E. Maryanoff, Han-Cheng Zhang
  • NOVEL 2-AMINO-3,4-DIHYDRO-PYRIDO[3,4-D]PYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF beta-SECRETASE (BACE)
    Publication number: 20070259898
    Abstract: The present invention is directed to novel 2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of ?-secretase, also known as ?-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.
    Type: Application
    Filed: October 25, 2006
    Publication date: November 8, 2007
    Inventors: Ellen Baxter, Christopher Creighton, Yifang Huang, Chi Luo, Michael Parker, Allen Reitz, Charles Reynolds, Tina Ross, Eric Strobel, Brett Tounge
  • Novel 2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE)
    Publication number: 20060079687
    Abstract: The present invention is directed to novel 2-amino-3,4-dihydro-quinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of ?-secretase, also known as ?-site cleaving enzyme and BACE.
    Type: Application
    Filed: August 4, 2005
    Publication date: April 13, 2006
    Inventors: Ellen Baxter, Francois Bischoff, Robert Boyd, Mirielle Braeken, Steve Coats, Yifang Huang, Alfonzo Jordan, Chi Luo, Marc Mercken, Serge Maria Pieters, Allen Reitz, Charles Reynolds, Tina Ross, Brett Tounge, Mark Schulz, Hans De Winter