Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts and esters thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which is associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

Abstract: A system and method for providing on-demand edge compute. The system may include an orchestrator that provides a UI and that controls an abstraction layer for implementing a workflow for providing on-demand edge compute. The abstraction layer may include a server configuration orchestration (SCO) system (e.g., a Metal-as-a-Service (MaaS) system) and API that may provide an interface between the orchestrator and the SCO. The API may enable the orchestrator to communicate with the SCO for receiving requests that enable the SCO to integrate with existing compute resources to perform various compute provisioning tasks (e.g., to build and provision a server instance). The various tasks, when executed, may provide on-demand edge compute service to users. The SCO API may further enable the ECS orchestrator to receive information from the SCO (e.g., compute resource information, status messages).

Abstract: The present invention provides compounds represented by Formula I, or pharmaceutically acceptable salts, stereoisomers, solvates, hydrates or combination thereof, The invention also provides pharmaceutical compositions comprising these compounds and methods of using this compounds for treating FXR-mediated or TGR5-mediated diseases or conditions.

Abstract: In an environment with multiple graphics software application framework, a rending application programming interface (API) agent is provided in a rendering API library. The rendering API agent is to find surface information on memory surfaces corresponding to rendering surfaces of the rendering API library and relationship information between the memory surfaces and a process of the redering API application. The rendering API agent is to communicate with a global scene graph library (GSGL) to send the surface information and the relationship information to the GSGL. Binding may be used to transform the memory surfaces to desired rendering API surfaces based on the surface information in GSGL. A user experience application is to manipulate the translated rendering API surfaces to create user experience.

Abstract: Systems and methods are described herein to provide for improved hardware device connectivity. Other embodiments include apparatus and system for receiving messages from an operating system and sending messages to one or more hardware devices. Further embodiments include methods for receiving messages from an operating system regarding operations on a hardware device and responding to those messages. Other embodiments include methods for receiving interrupt messages and mapping those interrupt messages to hardware devices. Other embodiments are described and claimed.

Abstract: Machine-readable media, methods, and apparatus are described. In some embodiments, a header policy for a packet to be transmitted through the network is defined based upon characteristics of the network and a header of the packet is compressed based upon whether the header policy indicates the header of the packet is to be compressed.

Abstract: A method and apparatus for low latency transport of signals. In some embodiments a method may include providing a buffer controller between two consecutive signal transmission processes between a host and a client to synchronize a write from a first of the two consecutive signal transmission processes and a read to a second of the of the two consecutive signal transmission processes, wherein the buffer controller includes a first buffer, a second buffer, and a first status list and a second status list that each provide an association status of the first buffer and the second buffer.

Abstract: Systems and methods are described herein to provide for improved hardware device connectivity. Other embodiments include apparatus and system for receiving messages from an operating system and sending messages to one or more hardware devices. Further embodiments include methods for receiving messages from an operating system regarding operations on a hardware device and responding to those messages. Other embodiments include methods for receiving interrupt messages and mapping those interrupt messages to hardware devices. Other embodiments are described and claimed.

Abstract: Machine-readable media, methods, and apparatus are described. In some embodiments, a header policy for a packet to be transmitted through the network is defined based upon characteristics of the network and a header of the packet is compressed based upon whether the header policy indicates the header of the packet is to be compressed.

Abstract: According to one embodiment of the invention, a method for receiving in a signal processing subsystem a first signal comprising a predetermined pattern and a second signal comprising the predetermined pattern, and determining by the signal processing subsystem a transmission latency between the received first signal and the received second signal based on the predetermined pattern. According to another embodiment a system comprising a pattern insertion subsystem to insert a predetermined pattern into a first signal and a second signal, and a signal processing subsystem to (i) receive the inserted first signal and the inserted second signal, and (ii) determine a transmission latency between the received signals based on the predetermined pattern.

Abstract: A method and apparatus for low latency transport of signals. In some embodiments a method may include providing a buffer controller between two consecutive signal transmission processes between a host and a client to synchronize a write from a first of the two consecutive signal transmission processes and a read to a second of the of the two consecutive signal transmission processes, wherein the buffer controller includes a first buffer, a second buffer, and a first status list and a second status list that each provide an association status of the first buffer and the second buffer.