Abstract: An isolated polypeptide having cytotoxic activity comprising the amino acid sequence of Pilosulin 1 shown in the figure, and active portion thereof, or a functionally equivalent amino acid sequence thereof, and a method of inhibiting the growth of a cell comprising exposing the cell to an effective amount of Pilosulin 1 shown in the figure, and active portion thereof, or a functionally equivalent amino acid sequence thereof, such that the growth of the cell is inhibited.

Abstract: A disposable medical testing device (17) adapted to be held against the skin of a patient, which enables the performance of skin testing for the diagnosis of both immediate hypersensitivity and delayed hypersensitivity immune reactions. The device is comprised of a hollow body with a sealed chamber in which is mounted a movable needle (3) capable of penetrating a patient's skin to a predetermined depth and a test reagent container (2). The device (17) is manipulable by a user to reduce the volume of the chamber and moving the needle thus releasing the reagent and causing penetration of the skin. The released reagent is delivered to the skin penetration site, and any resulting skin reaction is observed and recorded. Embodiments of the invention marked with a calibrated scale on a releasable transparent layer and details of patient and test date which allow multiple antigen tests to be performed are also disclosed. A method of testing for immune response using the device (17) is also disclosed.

Abstract: The invention concerns antigens for the production of antibodies to Platelet Activating Factor (PAF). The antigens are PAF analogues of formula (I) ##STR1## wherein X comprises a high molecular weight group, R.sup.1 is a linking group and R.sup.2 to R.sup.5 are selected from C.sub.1 to C.sub.6 alkyl.Other aspects of the invention include PAF-antibodies produced using said antigens, labelled PAF analogues, intermediates for the preparation of PAF analogues and methods and a kit for the immunoassay of PAF.