Patents by Inventor Brian A. Donahue

Brian A. Donahue has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20040071659
    Abstract: The present invention provides anti-angiogenic compositions and methods, based on gene delivery vectors that include the coding sequence for an anti-angiogenic compound.
    Type: Application
    Filed: April 29, 2002
    Publication date: April 15, 2004
    Inventors: Betty Chang, Wei Wei Wu, James McArthur, Salil D. Patel, Karin Jooss, Michael J. Mendez, Brian A. Donahue
  • Patent number: 6586208
    Abstract: Suppressor tRNA's are used to regulate expression of transgenes that are toxic, or the expression thereof requires a factor that is toxic, to the host cell.
    Type: Grant
    Filed: February 16, 2001
    Date of Patent: July 1, 2003
    Assignee: Cell Genesys, Inc.
    Inventors: Brian A. Donahue, Stephen F. Hardy, Richard O. Snyder
  • Patent number: 6475791
    Abstract: Methods disclosed herein capitalize on the ability of DNA Structure Specific Recognition Proteins (SSRPs) to bind to genomic lesions formed by chemotherapeutic agents, particularly cisplatin-type agents. Methods are provided for predicting whether an agent that damages DNA will also be cytotoxic, and for predicting whether particular eukaryotic cells will be susceptible to killing by a genotoxic drug. A screening method is provided for identifying new genotoxic drugs that produce SSRP-recognized lesions in DNA. Methods also are provided for sensitizing particular eukaryotic cells to killing by chemotherapeutic agents, particularly cisplatin-type drugs.
    Type: Grant
    Filed: June 2, 1997
    Date of Patent: November 5, 2002
    Assignee: Massachusetts Institute of Technology
    Inventors: Stephen J. Lippard, John M. Essigmann, Brian A. Donahue, Jeffrey H. Toney, Suzanne L. Bruhn, Pieter M. Pil, Steven J. Brown, Patti J. Kellett
  • Publication number: 20020076808
    Abstract: Suppressor tRNA's are used to regulate expression of transgenes that are toxic, or the expression thereof requires a factor that is toxic, to the host cell.
    Type: Application
    Filed: February 16, 2001
    Publication date: June 20, 2002
    Inventors: Brian A. Donahue, Stephen F. Hardy, Richard O. Snyder
  • Patent number: 5670621
    Abstract: DNA structure specific recognition protein of eukaryotic origin and DNA encoding such a factor, as well as probes specific for DNA structure specific recognition protein or DNA encoding it and methods of detecting DNA structure specific recognition protein in eukaryotic cells. In particular, a mammalian cellular factor that selectively recognizes and binds DNA damaged or modified by a drug (the anticancer drug, cis-diamminedichloroplatinum (II) or cisplatin) has been identified.
    Type: Grant
    Filed: June 9, 1994
    Date of Patent: September 23, 1997
    Assignee: Massachusetts Institute of Technology
    Inventors: Brian A. Donahue, Jeffrey H. Toney, John M. Essigmann, Stephen J. Lippard, Pieter M. Pil, Suzanne L. Bruhn, Steven J. Brown, Patti J. Kellett
  • Patent number: 5359047
    Abstract: DNA structure specific recognition protein of eukaryotic origin and DNA encoding such a factor, as well as probes specific for DNA structure specific recognition protein or DNA encoding it and methods of detecting DNA structure specific recognition protein in eukaryotic cells. In particular, a mammalian cellular factor that selectively recognizes and binds DNA damaged or modified by a drug (the anticancer drug, cis-diamminedichloroplatinum (II) or cisplatin) has been identified.
    Type: Grant
    Filed: December 26, 1991
    Date of Patent: October 25, 1994
    Assignee: Massachusetts Institute of Technology
    Inventors: Brian A. Donahue, Jeffrey H. Toney, John M. Essigmann, Stephen J. Lippard, Pieter M. Pil, Suzanne L. Bruhn, Steven J. Brown, Patti J. Kellett