Patents by Inventor Brian A. Fox

Brian A. Fox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7241870
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-? at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: July 10, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Scott R. Presnell, Brian A. Fox, Teresa Gilbert, Betty A. Haldeman, Francis J. Grant
  • Publication number: 20070141676
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-? at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
    Type: Application
    Filed: October 5, 2006
    Publication date: June 21, 2007
    Inventors: Paul Sheppard, Brian Fox, Kevin Klucher, David Taft, Wayne Kindsvogel
  • Publication number: 20070128158
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-? at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
    Type: Application
    Filed: October 5, 2006
    Publication date: June 7, 2007
    Inventors: Paul Sheppard, Brian Fox, Kevin Klucher, David Taft, Wayne Kindsvogel
  • Publication number: 20070128205
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-? at the amino acid sequence level. The receptor for this protein family is a class TI cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
    Type: Application
    Filed: October 5, 2006
    Publication date: June 7, 2007
    Inventors: Paul Sheppard, Brian Fox, Kevin Klucher, David Taft, Wayne Kindsvogel
  • Publication number: 20070129538
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zycto24, and zcyto25 proteins which are most closely related to interferon-? at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, and methods of producing the polynucleotides and polypeptides.
    Type: Application
    Filed: October 5, 2006
    Publication date: June 7, 2007
    Inventors: Paul Sheppard, Brian Fox, Kevin Klucher, David Taft, Wayne Kindsvogel
  • Publication number: 20070052777
    Abstract: Embodiments provide a system and method for cleaning inkjet cartridges. The system includes a fixture configured to mount an inkjet cartridge where a printhead of the inkjet cartridge is mounted to a cleaning plate. The cleaning plate includes one or more orifices connected to a vacuum source and one or more orifices connected to a wash solution source. The vacuum source can be used to extract ink from within the cartridge through nozzles in the printhead. The wash solution source can supply a pressurized wash solution through the nozzles of the printhead. The vacuum source can also be use to extract the wash solution from within the cartridge through the nozzles.
    Type: Application
    Filed: September 6, 2006
    Publication date: March 8, 2007
    Inventors: Jason Guhse, Herb Sarnoff, Scott Shultz, Brian Fox
  • Publication number: 20070052767
    Abstract: Embodiments provide a method of refilling an inkjet printer cartridge. The method includes providing an inkjet printer cartridge and lowering the pressure surrounding the cartridge below atmospheric level. A first volume of ink is directed into the cartridge at the reduced pressure. The method further includes at least partially raising the pressure surrounding the cartridge and subsequently at least partially lowering the pressure surrounding the cartridge. A second volume of ink is then directed into the cartridge at the second reduced pressure.
    Type: Application
    Filed: September 6, 2006
    Publication date: March 8, 2007
    Inventors: Jason Guhse, Scott Shultz, Brian Fox, Donald Ulry
  • Publication number: 20070053903
    Abstract: The invention provides pHHLA2 co-receptor polypeptides and functional fragments, antibodies to same, isolated polynucleotides encoding same, vectors containing the polynucleotides, cells containing the vectors. Methods of making and using these co-stimulatory pHHLA2 co-receptors molecules are also disclosed.
    Type: Application
    Filed: May 12, 2006
    Publication date: March 8, 2007
    Inventors: Zeren Gao, Brian Fox, Steven Levin, Frederick Ramsdell, Edward Howard, Janine Bilsborough
  • Publication number: 20070051421
    Abstract: Embodiments provide an inkjet cartridge refilling system. The system may include a drill station configured to drill at least one refilling hole in an inkjet printer cartridge. The system may include an evacuation station configured to remove excess ink from the inkjet printer cartridge. In some embodiments, the excess ink is removed via a vacuum source. The system may also include a filling station configured to provide any of a plurality of inks into the cartridge. Some embodiments provide the ink to the inkjet cartridge via a hole drilled in the cartridge. Other embodiments provide the ink via inkjet nozzles of the inkjet printer cartridge. The system may also include a test station configured to test the refilled cartridge to determine whether it is functioning properly after being filled with ink.
    Type: Application
    Filed: September 6, 2006
    Publication date: March 8, 2007
    Inventors: Herb Sarnoff, Jason Guhse, Brian Fox, Scott Shultz, Cecilia Gonzales, George Popa, Keith Kopitzke, Keith Emery
  • Publication number: 20070048828
    Abstract: Proteins consisting of, from amino to carboxyl terminus, a first PDGF-D growth factor domain polypeptide, a linker polypeptide, and a second PDGF-D growth factor domain polypeptide, and materials and methods for making the proteins are disclosed. Each of the first and second PDGF-D growth factor domain polypeptides consists of a sequence of amino acid residues as shown in SEQ ID NO:2 or SEQ ID NO:4 from amino acid x to amino acid y, wherein x is an integer from 246 to 258, inclusive, and y is an integer from 365-370, inclusive. The linker polypeptide consists of from 11-40 amino acid residues. The proteins can be used to stimulate the production of bone and/or connective tissue in both humans and non-human animals.
    Type: Application
    Filed: October 17, 2006
    Publication date: March 1, 2007
    Inventors: Brian Fox, Margaret Moore, Kristine Swiderek, Carl Birks
  • Publication number: 20070049736
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-? at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
    Type: Application
    Filed: October 10, 2006
    Publication date: March 1, 2007
    Inventors: Paul Sheppard, Scott Presnell, Brian Fox, Teresa Gilbert, Betty Haldeman, Francis Grant
  • Publication number: 20070048841
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-? at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
    Type: Application
    Filed: October 10, 2006
    Publication date: March 1, 2007
    Inventors: Paul Sheppard, Scott Presnell, Brian Fox, Teresa Gilbert, Betty Haldeman, Francis Grant
  • Patent number: 7183391
    Abstract: We claim the proteinase inhibitors comprising a Kunitz domain, wherein the Kunitz domain comprises amino acid residues 57–107 of SEQ ID NO: 2. We also claim a fusion protein comprising said Kunitz domain. In addition, we claim a method of inhibiting protease degradation or protease activity in a composition which contains plasma proteins and proteases. The proteinase inhibitors is used as components of cell culture media in cell culture process, and as inhibitors of protease-mediated degradation of plasma proteins in protein purification.
    Type: Grant
    Filed: March 16, 2005
    Date of Patent: February 27, 2007
    Assignee: ZymoGenetics, Inc.
    Inventors: Paul O. Sheppard, Brian A. Fox
  • Publication number: 20070042468
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-? at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
    Type: Application
    Filed: October 10, 2006
    Publication date: February 22, 2007
    Inventors: Paul Sheppard, Scott Presnell, Brian Fox, Teresa Gilbert, Betty Haldeman, Francis Grant
  • Publication number: 20070043209
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-? at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.
    Type: Application
    Filed: October 10, 2006
    Publication date: February 22, 2007
    Inventors: Paul Sheppard, Scott Presnell, Brian Fox, Teresa Gilbert, Betty Haldeman, Francis Grant
  • Publication number: 20060263851
    Abstract: A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
    Type: Application
    Filed: July 18, 2006
    Publication date: November 23, 2006
    Inventors: Donald Foster, Wenfeng Xu, Karen Madden, James Kelly, Cindy Sprecher, Cameron Brandt, Mark Rixon, Scott Presnell, Brian Fox
  • Publication number: 20060263850
    Abstract: A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
    Type: Application
    Filed: July 18, 2006
    Publication date: November 23, 2006
    Inventors: Donald Foster, Wenfeng Xu, Karen Madden, James Kelly, Cindy Sprecher, Cameron Brandt, Mark Rixon, Scott Presnell, Brian Fox
  • Patent number: 7122351
    Abstract: Proteins consisting of two PDGF-D polypeptide chains, polynucleotides encoding the polypeptides, and materials and methods for making the proteins are disclosed. Each of the polypeptide chains consists of, from amino terminus to carboxyl terminus, the following operably linked segments: P1-P2-h-CH2-CH3; P1-P2-CH2-CH3; h-CH2-CH3-P2-P1; or CH2-CH3-P2-P1. Within these polypeptide chains, P1 is a first polypeptide segment as shown in SEQ ID NO:2 or SEQ ID NO:4 from amino acid x to amino acid y, wherein x is an integer from 246 to 258, inclusive, and y is an integer from 365–370, inclusive; P2 is a second polypeptide segment consisting of from 4 to 20 amino acid residues; h is an immunoglobulin hinge region or portion thereof; and CH2 and CH3 are CH2 and CH3 domains of an immunoglobulin heavy chain, respectively. Within the protein, the two polypeptide chains are joined by one or more disulfide bonds, each of the chains is optionally glycosylated, and the protein binds to and activates cell-surface PDGF receptors.
    Type: Grant
    Filed: October 18, 2002
    Date of Patent: October 17, 2006
    Assignee: ZymoGenetics, Inc.
    Inventors: Margaret Dow Moore, Brian A. Fox
  • Patent number: 7122632
    Abstract: A soluble receptor to IL-20 having two polypeptide subunits, IL-20RA (formerly called ZcytoR7) and IL-20RB (formerly called DIRS1). The two subunits are preferably linked together. In one embodiment one subunit is fused to the constant region of the light chain of an immunoglobulin, and the other subunit is fused to the constant region of the heavy chain of the immunoglobulin. The light chain and the heavy chain are connected via a disulfide bond.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: October 17, 2006
    Assignee: ZymoGenetics, Inc.
    Inventors: Donald C. Foster, Wenfeng Xu, Karen L. Madden, James D. Kelly, Cindy A. Sprecher, Cameron S. Brandt, Mark W. Rixon, Scott R. Presnell, Brian A. Fox
  • Patent number: 7117416
    Abstract: A method and apparatus for providing a system-on-a-chip comprising a processor and a configurable system logic (CSL) including a plurality of banks arranged in an array coupled to the processor. The system on a chip further includes a built-in self test (BIST) mechanism coupled to the CSL to perform tests on the CSL to verify that the banks and interconnections between the banks are functioning properly.
    Type: Grant
    Filed: December 23, 2004
    Date of Patent: October 3, 2006
    Assignee: Xilinx, Inc.
    Inventor: Brian Fox