Abstract: Anti-PSMA antibodies (e.g., UniAbs™) and CAR-T structures are disclosed, along with methods of making such antibodies and CAR-T structures, compositions, including pharmaceutical compositions, comprising such antibodies and CAR-T structures, and their use to treat disorders that are characterized by the expression of PSMA.

Abstract: Ani-CD20 antibodies (e.g., UniAbs™) and CAR-T structures are disclosed, along with methods of making such antibodies and CAR-T structures, compositions, including pharmaceutical compositions, comprising such antibodies and CAR-T structures, and their use to treat disorders that are characterized by the expression of CD20.

Abstract: A method for producing a neutrons includes triggering a raising or a lowering of a temperature of a pyroelectric crystal of less than about 40° C. to produce a voltage of negative polarity of at least ?100 keV on a surface of a deuterated or tritiated target coupled thereto. A deuterium ion source is pulsed to produce a deuterium ion beam. The accelerating of the deuterium ion beam is achieved by accelerating voltage of the pyroelectric crystal toward the deuterated or tritiated target to produce neutrons. Furthermore, the pyroelectric crystal, the deuterated or tritiated target, and the deuterium ion source are coupled to a common support. The method also includes throwing the common support housing the pyroelectric crystal, the deuterated or tritiated target, and the deuterium ion source near an unknown threat for identification thereof.

Abstract: Disclosed herein is a door lock configured to indicate the lock status of the door lock to nearby persons. In some instances, the door lock includes a locking mechanism with one or more actuators configured to act directly on an indicator such that the indicator indicates the lock status of the lock.

Abstract: Embodiments relate to an off-road vehicle comprising a frame, including at least one cargo box support member, a suspension movably coupled to the frame, a passenger compartment, an engine, a transmission operatively coupled to the engine, and a cargo box. The cargo box includes a floor and a plurality of upwardly extending sidewalls, wherein at least a portion of the cargo box floor extends over the at least one cargo box support member and wherein the cargo box is removably coupled to the at least one cargo box support members and is removable from the off-road vehicle via the removal of fewer than eight fasteners.

Abstract: An off-road vehicle includes a frame, a front suspension, and a rear suspension. In some examples of the off-road vehicle, the rear suspension includes trailing arms with are pivotally attached to the frame rearward of an operator area. Further, the frame can include a front subframe assembly and a rear subframe assembly which are easily removable from the main frame of the vehicle to permit access to various components of the off-road vehicle.

Abstract: A system and method for combining the inputs of various sensors used in platforms, primarily those having a military use, having or making use of a number of inputs capable of determining information about an environment in which they are operating. Each input is configured to output a standardized set of information regarding its capabilities and the environment in which it is operating. A correlator is configured to adaptably process the information based on rules contained in at least one changeable correlation matrix and information contained in at least one changeable configuration file. The information, or simply an alert, is provided to at least one output that provides the information to a human operator.

Abstract: A method and system for rehabilitation of a patient having a physical impairment by providing music therapy, the method being implemented on a computer system having one or more physical processors configured by machine-readable instructions which, when executed perform the method, includes receiving biomechanical data from the patient regarding repetitive movements of the patient and determining a baseline condition; determining a baseline beat tempo having a constant frequency based on the baseline condition; providing music to the patient, the music having beat signals at the baseline beat tempo; providing a cue to the patient to perform each repetitive movement in time with an associated beat signal; receiving time-stamped biomechanical data of the patient relating to the repetitive movements performed by the patient in time with the baseline beat signals; analyzing the biomechanical data to identify an onset time of one or more cycles of the repetitive movement; determining an entrainment parameter based

Abstract: An off-road vehicle includes a frame, a front suspension, and a rear suspension. In some examples of the off-road vehicle, the rear suspension includes trailing arms with are pivotally attached to the frame rearward of an operator area. Further, the frame can include a front subframe assembly and a rear subframe assembly which are easily removable from the main frame of the vehicle to permit access to various components of the off-road vehicle.

Abstract: A method of providing repetitive motion therapy comprising providing access to audio content; selecting audio content for delivery to a patient; performing an analysis on the selected audio content, the analysis identifying audio features of the selected audio content, and extracting rhythmic and structural features of the selected audio content; performing an entrainment suitability analysis on the selected audio content; generating entrainment assistance cue(s) to the selected audio content, the assistance cue(s) including a sound added to the audio content; applying the assistance cues to the audio content simultaneously with playing the selected audio content; evaluating a therapeutic effect on the patient, wherein the selected audio content continues to play when a therapeutic threshold is detected, and a second audio content is selected for delivery to the patient when a therapeutic threshold is not detected.

Abstract: A method of providing repetitive motion therapy comprising providing access to audio content; selecting audio content for delivery to a patient; performing an analysis on the selected audio content, the analysis identifying audio features of the selected audio content, and extracting rhythmic and structural features of the selected audio content; performing an entrainment suitability analysis on the selected audio content; generating entrainment assistance cue(s) to the selected audio content, the assistance cue(s) including a sound added to the audio content; applying the assistance cues to the audio content simultaneously with playing the selected audio content; evaluating a therapeutic effect on the patient, wherein the selected audio content continues to play when a therapeutic threshold is detected, and a second audio content is selected for delivery to the patient when a therapeutic threshold is not detected.

Abstract: An off-road vehicle includes a frame, a front suspension, and a rear suspension. In some examples of the off-road vehicle, the rear suspension includes trailing arms with are pivotally attached to the frame rearward of an operator area. Further, the frame can include a front subframe assembly and a rear subframe assembly which are easily removable from the main frame of the vehicle to permit access to various components of the off-road vehicle.

Abstract: A content management system may maintain a scene description that represents a 3D world using hierarchical relationships between elements in a scene graph. Clients may exchange delta information between versions of content being edited and/or shared amongst the clients. Each set of delta information may be assigned a value in a sequence of values which defines an order to apply the sets of delta information to produce synchronized versions of the scene graph. Clients may follow conflict resolution rules to consistently resolve conflicts between sets of delta information. Changes to structural elements of content may be represented procedurally to preserve structural consistency across clients while changes to non-structural elements may be represented declaratively to reduce data size. To store and manage the content, structural elements may be referenced using node identifiers, and non-structural elements may be assigned to the node identifiers as field-value pairs.

Abstract: A content management system may maintain a scene description that represents a 3D virtual environment and a publish/subscribe model in which clients subscribe to content items that correspond to respective portions of the shared scene description. When changes are made to content, the changes may be served to subscribing clients. Rather than transferring entire descriptions of assets to propagate changes, differences between versions of content may be exchanged, which may be used construct updated versions of the content. Portions of scene description may reference other content items and clients may determine whether to request and load these content items for lazy loading. Content items may be identified by Uniform Resource Identifiers (URIs) used to reference the content items. The content management system may maintain states for client connections including for authentication, for the set of subscriptions in the publish/subscribe model, and for their corresponding version identifiers.

Abstract: A content management system may maintain a scene description that represents a 3D virtual environment and a publish/subscribe model in which clients subscribe to content items that correspond to respective portions of the shared scene description. When changes are made to content, the changes may be served to subscribing clients. Rather than transferring entire descriptions of assets to propagate changes, differences between versions of content may be exchanged, which may be used construct updated versions of the content. Portions of scene description may reference other content items and clients may determine whether to request and load these content items for lazy loading. Content items may be identified by Uniform Resource Identifiers (URIs) used to reference the content items. The content management system may maintain states for client connections including for authentication, for the set of subscriptions in the publish/subscribe model, and for their corresponding version identifiers.

Abstract: A method and system for augmented neurologic rehabilitation (ANR) of a patient is disclosed. The ANR system generates rhythmic auditory stimulus (RAS) and a visual augmented reality (AR) scene that are synchronized according to a common beat tempo and output to the patient during a therapy session. Sensor worn by the patient capture biomechanical data relating to repetitive movements performed by the patient in sync with the AR visual content and RAS. A critical thinking algorithm analyzes the sensor data to determine a spatial and temporal relationship of the patient's movements relative to the visual and audio elements and determine a level of entrainment of the patient and progression toward clinical/therapeutic goals. Additionally, a 3D AR modelling module configures the processor to dynamically adjust the augmented-reality visual and audio content output to the patient based on the determined level of entrainment and whether a training goal has been achieved.

Abstract: A method and system for rehabilitation of a patient having a physical impairment by providing repetitive motion therapy is disclosed. The system is configured to receive biomechanical data from the patient regarding repetitive movements of the patient performed using a first and second side of the body, respectively, and select, based on the data, an entrainment side according to which repetitive motion therapy is provided. The system further performs repetitive motion therapy by: providing the patient auditory stimulus comprising beat signals output at respective beat times; receiving time-stamped biomechanical data for repetitive movements performed by the patient using the entrainment side in relation to the respective beat times of the beat signals; calculating an entrainment potential for the entrainment side by comparing a timing of the repetitive movements to the timing of the beat signals; and modifying the auditory stimulus as a function of the calculated entrainment potential.

Abstract: A content management system may maintain a scene description that represents a 3D virtual environment and a publish/subscribe model in which clients subscribe to content items that correspond to respective portions of the shared scene description. When changes are made to content, the changes may be served to subscribing clients. Rather than transferring entire descriptions of assets to propagate changes, differences between versions of content may be exchanged, which may be used construct updated versions of the content. Portions of scene description may reference other content items and clients may determine whether to request and load these content items for lazy loading. Content items may be identified by Uniform Resource Identifiers (URIs) used to reference the content items. The content management system may maintain states for client connections including for authentication, for the set of subscriptions in the publish/subscribe model, and for their corresponding version identifiers.

Abstract: A method of providing repetitive motion therapy comprising providing access to audio content; selecting audio content for delivery to a patient; performing an analysis on the selected audio content, the analysis identifying audio features of the selected audio content, and extracting rhythmic and structural features of the selected audio content; performing an entrainment suitability analysis on the selected audio content; generating entrainment assistance cue(s) to the selected audio content, the assistance cue(s) including a sound added to the audio content; applying the assistance cues to the audio content simultaneously with playing the selected audio content; evaluating a therapeutic effect on the patient, wherein the selected audio content continues to play when a therapeutic threshold is detected, and a second audio content is selected for delivery to the patient when a therapeutic threshold is not detected.