Patents by Inventor Brian A. Irving

Brian A. Irving has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6407221
    Abstract: Chimeric proteins and DNA encoding chimeric proteins are provided, where the chimeric proteins are characterized by an extracellular domain capable of binding to a ligand in a non-MHC restricted manner, a transmembrane domain and a cytoplasmic domain capable of activating a signaling pathway. The extracellular domain and cytoplasmic domain are not naturally found together. Binding of ligand to the extracellular domain results in transduction of a signal and activation of a signaling pathway in the cell, whereby the cell may be induced to carry out various functions relating to the signalling pathway. A wide variety of extracellular domains may be employed as receptors, where such domains may be naturally occurring or synthetic. The chimeric DNA may be used to modify lymphocytes as well as hematopoietic stem cells as precursors to a number of important cell types.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: June 18, 2002
    Assignees: Cell Genesys, Inc., Regents of the University of California
    Inventors: Daniel J. Capon, Arthur Weiss, Brian A. Irving, Margo R. Roberts, Krisztina Zsebo
  • Patent number: 6319494
    Abstract: Chimeric proteins and DNA encoding chimeric proteins are provided, where the chimeric proteins are characterized by an extracellular domain capable of binding to a ligand in a non-MHC restricted manner, a transmembrane domain and a cytoplasmic domain capable of activating a signaling pathway. The extracellular domain and cytoplasmic domain are not naturally found together. Binding of ligand to the extracellular domain results in transduction of a signal and activation of a signaling pathway in the cell, whereby the cell may be induced to carry out various functions relating to the signalling pathway. A wide variety of extracellular domains may be employed as receptors, where such domains may be naturally occurring or synthetic. The chimeric DNA may be used to modify lymphocytes as well as hematopoietic stem cells as precursors to a number of important cell types.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 20, 2001
    Assignee: Cell Genesys, Inc.
    Inventors: Daniel J. Capon, Arthur Weiss, Brian A. Irving, Margo R. Roberts, Krisztina Zsebo
  • Patent number: 5359046
    Abstract: Chimeric proteins and DNA sequence encoding chimeric proteins are provided, where the chimeric proteins are characterized by an extracellular domain capable of binding to a ligand in a non-MHC restricted manner, a transmembrane domain and a cytoplasmic domain capable of activating a signaling pathway. The extracellular domain and cytoplasmic domain are not naturally found together. Binding of ligand to the extracellular domain results in transduction of a signal and activation of a signaling pathway in the cell, whereby the cell may be induced to carry out various functions relating to the signalling pathway. A wide variety of extracellular domains may be employed as receptors, where such domains may be naturally occurring or synthetic. The chimeric DNA sequences may be used to modify lymphocytes as well as hematopoietic stem cells as precursors to a number of important cell types.
    Type: Grant
    Filed: December 9, 1992
    Date of Patent: October 25, 1994
    Assignees: Cell Genesys, Inc., The Regents of the University of California
    Inventors: Daniel J. Capon, Arthur Weiss, Brian A. Irving, Margo R. Roberts, Krisztina Zsebo
  • Patent number: 5221709
    Abstract: This invention relates to a sealing composition for a mineral insulated electric cable termination. The sealing composition includes an inert filler such as silica flour, a low vapor pressure organic material such as a polyphenyl ether and an aerosil. This composition has improved slump resistance at high temperatures with little run out and no tendency to crack at 250.degree. C.
    Type: Grant
    Filed: October 8, 1991
    Date of Patent: June 22, 1993
    Assignee: Associated Electrical Industries Limited
    Inventors: Brian A. Irving, Robert J. W. Powell
  • Patent number: 4904047
    Abstract: An optical fibre cable includes, within a surrounding cover, at least one optical fibre extending longitudinally, and a hydrogen-absorptive material comprising a metal cation and an organic anion, preferably dispersed or dissolved in a water-blocking compound. The hydrogen-absorptive material may be a metal salt, preferably a silver salt, of a carboxylic acid, or else a metal loaded ion exchange resin.
    Type: Grant
    Filed: March 14, 1989
    Date of Patent: February 27, 1990
    Assignee: Telephone Cables Limited
    Inventors: Robert J. W. Powell, Brian A. Irving