Patents by Inventor Brian A. Johns

Brian A. Johns has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 1,2,3,3a,4,5,7,9,13,13a-decahydropyrido[1?,2?:4,5]pyrazino[1,2-a]pyrrolo[1,2-c]pyrimidines having HIV integrase inhibitory activity
    Patent number: 11267823
    Abstract: Substituted 1,2,3,3a,4,5,7,9,13,13a-decahydropyrido[1?,2?:4,5]pyrazino[1,2-a]pyrrolo[1,2-c]pyrimidines having the anti-virus activity, particularly the HIV integrase inhibitory activity, and a pharmaceutical composition containing the same, particularly an anti-HIV pharmaceutical composition.
    Type: Grant
    Filed: July 9, 2020
    Date of Patent: March 8, 2022
    Assignees: SHIONOGI & CO., LTD., VIIV HEALTHCARE COMPANY
    Inventors: Brian A. Johns, Takashi Kawasuji, Teruhiko Taishi, Yoshiyuki Taoda
  • N-[(2,4-difluorophenyl)methyl]-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3] oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide having HIV integrase inhibitory activity
    Patent number: 10927129
    Abstract: The present invention is directed to N-[(2,4-difluorophenyl)methyl]-6-hydroxy-3-methyl-5,7-dioxo-2,3,5,7,11,11a-hexahydro[1,3]oxazolo[3,2-a]pyrido[1,2-d]pyrazine-8-carboxamide of the formula: or a pharmaceutically acceptable salt or stereoisomer thereof, and pharmaceutical compositions comprising the same. The present invention has HIV integrase inhibitory activity.
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: February 23, 2021
    Assignees: SHINOGI & CO., LTD., VIIV HEALTHCARE COMPANY
    Inventors: Brian A. Johns, Takashi Kawasuji, Teruhiko Taishi, Yoshiyuki Taoda
  • Substituted pyrido[1',2':4,5]pyrazino[1,2-a]pyrimidines as HIV integrase inhibitors
    Patent number: 9273065
    Abstract: The present invention is directed to a class of substituted pyrido[1?2?:4,5]pyrazino[1,2-a]-pyrimidines useful as intermediates in the production of anti-HIV agents. The compounds have the formula (I-24b): wherein Re is one or two halogen; Rz is C1-8alkyl; Rz is hydrogen, C3-6cycloalkyl, heterocyclyl, or C1-8alkyl optionally substituted with hydroxy, C3-6cycloalkyl, alkoxy, heterocyclyl, heteroaryl, C6-14aryl, or amino, wherein said amino may be optionally substituted with —C(O)C1-8alkyl or C1-8alkyl; and P1 is C6-14arylC1-8alkyl; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 30, 2015
    Date of Patent: March 1, 2016
    Assignees: Shionogi & Co., Ltd., ViiV Healthcare Company
    Inventors: Brian A. Johns, Takashi Kawasuji, Teruhiko Taishi, Yoshiyuki Taoda
  • Substituted 10-hydroxy-9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydro-1h-pyrido[1,2-a]pyrrolo[1?,2?:3,4]imidazo[1,2-d]pyrazine-8-carboxamides
    Patent number: 9051337
    Abstract: The present invention is to provide a novel compound (I) shown below, having the anti-virus activity; particularly the HIV integrase inhibitory activity, and a drug containing the same, particularly an anti-HIV drug, as well as a process and an intermediate thereof. (wherein Z1 is NR4; R1 is hydrogen or lower alkyl; X is a single bond, a hetero atom group selected from O, S, SO, SO2 and NH, or lower alkylene or lower alkenylene in which the hetero atom group may intervene; R2 is optionally substituted aryl; R3 is hydrogen, a halogen, hydroxy, optionally substituted lower alkyl etc; and R4 and Z2 part taken together forms a ring, to form a polycyclic compound, including e.g., a tricyclic or tetracyclic compound.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 9, 2015
    Assignees: Shionogi & Co., Ltd., ViiV Healthcare Company
    Inventors: Brian A. Johns, Takashi Kawasuji, Teruhiko Taishi, Yoshiyuki Taoda
  • Substituted 10-hydroxy-9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydro-1-pyrido[1,2-?]pyrrolo[1?,2?:3,4]imidazo[1,2-]pyrazine-8-carboxamides
    Patent number: 8778943
    Abstract: The present invention is directed to a class of substituted 10-hydroxy-9,11-dioxo-2,3,4a,5,9,11,13,13a-octahydro-1H-pyrido[1,2-a]pyrrolo[1?,2?:3,4]imidazo[1,2-d]pyrazine-8-carboxamides useful as anti-HIV agents. The compounds have the formula (I-1-1): wherein ring A is an optionally substituted hexahydro-1H-pyrrolo[1,2-c]-imidazole; R14 and RX are independently hydrogen or optionally substituted lower alkyl; R3 is selected from various groups; R1 is hydrogen or lower alkyl; R is halogen; m is 0, 1, 2 or 3; or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: July 15, 2014
    Assignees: Shionogi & Co., Ltd., ViiV Healthcare Company
    Inventors: Brian A. Johns, Takashi Kawasuji, Teruhiko Taishi, Yoshiyuki Taoda
  • 1-(2,3-dihydroxypropyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic acid of the formula P-6 and/or methyl 1-(2,3-dihydroxypropyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylate of the formula P-7
    Patent number: 8765965
    Abstract: The compounds are intermediates in the preparation of therapeutic agents useful in the treatment of viral infections, particularly HIV infection. The compounds are 1-(2,3-dihydroxypropyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylic acid of the formula P-6 and/or methyl 1-(2,3-dihydroxypropyl)-4-oxo-3-[(phenylmethyl)oxy]-1,4-dihydro-2-pyridinecarboxylate of the formula P-7.
    Type: Grant
    Filed: October 2, 2013
    Date of Patent: July 1, 2014
    Assignees: Shionogi & Co., Ltd., ViiV Healthcare Company
    Inventors: Brian A. Johns, Jason G. Weatherhead, Toshikazu Hakogi, Yasunori Aoyama
  • Prodrugs of (4aS, 13ar)-N-[(2,4-difluorophenyl)methyl]-10-hydroxy-9-11-dioxo-2,3,4a,5,9,11,13,13a-octahydro-1H-pyrido[1,2-a]pyrrolo[1?,2?:3:4]imidazo[1,2-d]pyrazine-8-carboxamide and their use in the treatment of HIV infection
    Patent number: 8691823
    Abstract: The present invention features compounds of formula (I) for the treatment or prevention of HIV infection and for the treatment of AIDS and ARC.
    Type: Grant
    Filed: February 19, 2013
    Date of Patent: April 8, 2014
    Assignees: Shionogi & Co., Ltd., ViiV Healthcare Company
    Inventors: Brian A. Johns, Jason G. Weatherhead, Yasunori Aoyama, Hiroshi Yoshida, Yoshiyuki Taoda
  • Chemical Compounds
    Publication number: 20110152303
    Abstract: Novel diarylpyrimidine derivatives and pharmaceutically acceptable salts, solvates or hydrates thereof, designed to inhibit HIV reverse transcriptase, are provided, and a pharmaceutical composition containing the same, especially an anti-HIV agent. More specifically, novel diarylpyrimidine derivatives that are derivatives of the HIV reverse transcriptase inhibitor TMC278 of formula (1a) are provided, and pharmaceutically acceptable salts, solvates or hydrates thereof.
    Type: Application
    Filed: December 16, 2010
    Publication date: June 23, 2011
    Applicant: GlaxoSmithKline LLC
    Inventor: Brian A Johns
  • Naphthyridine Integrase Inhibitors
    Publication number: 20110003794
    Abstract: The present invention features compounds that are HIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.
    Type: Application
    Filed: August 30, 2010
    Publication date: January 6, 2011
    Inventor: Brian A Johns
  • Naphthyridine integrase inhibitors
    Patent number: 7812016
    Abstract: The present invention features compounds that are HIV integrase inhibitors and therefore are useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.
    Type: Grant
    Filed: May 12, 2004
    Date of Patent: October 12, 2010
    Assignee: SmithKline Beecham Corporation
    Inventor: Brian A. Johns
  • Hiv Integrase Inhibitors
    Publication number: 20080234231
    Abstract: The present invention features compounds that are HIV integrase inhibitors and may be useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.
    Type: Application
    Filed: July 28, 2006
    Publication date: September 25, 2008
    Inventors: Brian A. Johns, Andrew Spaltenstein
  • Hiv Integrase Inhibitors
    Publication number: 20080214527
    Abstract: The present invention features compounds that are HIV integrase inhibitors useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.
    Type: Application
    Filed: July 28, 2006
    Publication date: September 4, 2008
    Inventors: Takashi Kawasuji, Brian A. Johns
  • Hiv Integrase Inhibitors
    Publication number: 20080214503
    Abstract: The present intention features compounds that are HIV integrase inhibitors and may be useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.
    Type: Application
    Filed: July 28, 2006
    Publication date: September 4, 2008
    Inventors: Brian A. Johns, Andrew Spaltenstein
  • Hiv Integrase Inhibitors
    Publication number: 20080194523
    Abstract: The present invention features compounds that are HIV integrase inhibitors and may be useful in the inhibition of HIV replication, the prevention and/or treatment of infection by HIV, and in the treatment of AIDS and/or ARC.
    Type: Application
    Filed: July 28, 2006
    Publication date: August 14, 2008
    Inventors: Brian A. Johns, Andrew Spaltenstein
  • Imidazo-Pyridine Derivatives For Use In The Treatment of Herpes Viral Infection
    Publication number: 20080139594
    Abstract: The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
    Type: Application
    Filed: May 3, 2006
    Publication date: June 12, 2008
    Inventors: Kristjan Gudmundsson, Brian A. Johns
  • Substituted pyrazolo [1,5-A] pyrimidinyls and pharmaceutical uses therefore
    Patent number: 7304068
    Abstract: The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
    Type: Grant
    Filed: April 30, 2003
    Date of Patent: December 4, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Kristjan S Gudmundsson, Brian A Johns
  • Pyrazolopyrimidine derivatives and pharmaceutical compositions containing them
    Patent number: 7247626
    Abstract: The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
    Type: Grant
    Filed: February 24, 2003
    Date of Patent: July 24, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Kristjan Gudmundsson, Brian A Johns
  • Imidazo-pyridine derivatives for use in the treatment of herpes viral infection
    Patent number: 7244740
    Abstract: The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
    Type: Grant
    Filed: September 23, 2002
    Date of Patent: July 17, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Kristjan Gudmundsson, Brian A Johns
  • Pyrazolo-pyridine derivatives as antiherpes agents
    Patent number: 7199120
    Abstract: The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
    Type: Grant
    Filed: November 20, 2002
    Date of Patent: April 3, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Kristjan Gudmundsson, Brian A Johns
  • Imidazo[1,2-?]pyridine derivatives for the prophylaxis and treatment of herpes viral infections
    Patent number: 7186714
    Abstract: The present invention provides compounds of formula (I) wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents
    Type: Grant
    Filed: June 10, 2002
    Date of Patent: March 6, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Kristjan Gudmundsson, Brian A. Johns