Abstract: Embodiments of the present invention provide diagnostic markers of immunosenescence and methods of identifying individuals with impaired immune function based on a combination of such markers obtained from various analyses, primarily from blood, testing immune function including the analysis of immune cell subset frequencies, gene expression, cytokine and chemokine levels, and signaling responses to stimulation with cytokines (‘cytokine response’). Particular combinations of markers can predict with high accuracy whether an individual will respond to active vaccination and become protected against recurring diseases.

Abstract: An apparatus for selectively advancing and/or rotating an elongate device, includes a carrier mounted for rotation about a primary axis and a pair of opposed rollers on the carrier adapted to drive the device in a direction along the primary axis. A mechanism drives at least one of the rollers has a first gear and a second gear. A first input selectively rotates the second gear in first or second directions to advance or retract the elongate device. A second input selectively rotates the carrier in first and second directions to rotate the elongate device. The operation of the second input alone simultaneously rotates and advances/retracts the elongate device, and the coordinated operation of the first and second inputs rotates the elongate device without advancement/retraction.

Abstract: A medical pump with an improved continuity low flow delivery system and method for use with a pumping chamber, for example in a cassette, is disclosed. The pump includes a pump drive for exerting a force on the pumping chamber and a sensor for sensing the force/pressure exerted by the pump drive on the pumping chamber. The pump drive position sensor senses the position of the pump drive. The medical pump also includes a processing unit and a memory having a programming code adapted to calculate the rate of change of the sensed force/pressure values and determine whether the rate of change of the sensed force/pressure values meets a rate of change threshold. Once the rate of change threshold is met, the programming code is adapted to calculate a remaining pump drive travel value for determining how much farther the pump drive should travel before the end of an effective pump cycle.

Abstract: A pump for one or more different process fluids is provided including a pumping chamber having a process fluid inlet and outlet coupled to a process fluid valve on each pumping chamber for selectively preventing and allowing flow of process fluid through the pumping chamber. An actuation mechanism for pumping actuating fluid to actuating fluid chambers is provided that is in communication with the actuating fluid chambers to permit flow into each actuating fluid chamber of incompressible actuating fluid. A diaphragm separates each pumping chamber from an associated actuating fluid chamber for separating process fluid from actuating fluid. The actuation mechanism is removable by a quick disconnect that provides for disconnection of the activation mechanism without affecting process fluid. Operation of the actuation mechanism to displace actuating fluid causes actuating fluid to flow only into each actuating fluid chamber having an opened process fluid valve, resulting in pumping.

Abstract: An apparatus for selectively advancing and/or rotating an elongate device, includes a carrier mounted for rotation about a primary axis and a pair of opposed rollers on the carrier adapted to receive and engage an elongate device between them, and drive the device in a direction along the primary axis. A drive mechanism for driving at least one of the pair of opposed rollers, the drive mechanism comprising a first gear pivotally mounted about a first axis perpendicular to the primary axis, a second gear engaging the first gear, rotatably mounted about an axis parallel to the primary axis. A first input for selectively rotating the second gear in first or second directions to advance or retract an elongate device engaged by the pair of opposed rollers. A second input for selectively rotating the carrier in first and second directions to rotate an elongate device engaged by the pair of opposed rollers.

Abstract: A medical pump with an improved continuity low flow delivery system and method for use with a pumping chamber, for example in a cassette, is disclosed. The pump includes a pump drive for exerting a force on the pumping chamber and a sensor for sensing the force/pressure exerted by the pump drive on the pumping chamber. The pump drive position sensor senses the position of the pump drive. The medical pump also includes a processing unit and a memory having a programming code adapted to calculate the rate of change of the sensed force/pressure values and determine whether the rate of change of the sensed force/pressure values meets a rate of change threshold. Once the rate of change threshold is met, the programming code is adapted to calculate a remaining pump drive travel value for determining how much farther the pump drive should travel before the end of an effective pump cycle.

Abstract: A medical pump with a closed loop stroke feedback system and method, for use with a pumping chamber, for example in a cassette, is disclosed. The pump includes a pumping element that intermittently pressurizes a pumping chamber during a pumping cycle. A pressure sensor detects the pressure exerted by the pumping element on the pumping chamber. A position sensor detects the position of the pumping element. A processing unit processes pressure data from the pressure sensor and position data from the position sensor to determine a calculated stroke volume of the pump for a pump cycle, and to adjust a stroke frequency of the pump to compensate for variation in the stroke volume.

Abstract: A method of providing a vehicle monitoring system for ensuring accurate vehicle milleage readings. A comparison is made between velocity measurements from several sources to detect unauthorized modifications made to a vehicle in an effort to ensure accurate vehicle odometer readings. The vehicle velocity measured on-board is compared with vehicle velocity data signals received from a remote satellite system in light of an allowable tolerance. The system will detect changes in the vehicle such as tire size or tampering with the vehicles on-board measurement devices. The system may communicate out of tolerance conditions to the vehicle operator and the fleet manager.

Abstract: A communications system for use in a vehicle that allows the user of the communications system to safely communicate from inside the vehicle. The communications system includes a memory for storing messages that will be transmitted by the driver to a receiving party, a sensor for sensing movement of the truck, a display unit coupled to the memory and the sensor for selectively displaying stored messages, a selector for selecting at least one stored message to be communicated to the receiving party, and a transmitter for transmitting the one or more stored messages. The display unit selectively displays the stored messages based on whether or not the vehicle is stopped preventing the operator from being distracted while driving.

Abstract: A method of providing a vehicle monitoring system for ensuring accurate vehicle miileage readings. A comparison is made between velocity measurements from several sources to detect unauthorized modifications made to a vehicle in an effort to ensure accurate vehicle odometer readings. The vehicle velocity measured on-board is compared with vehicle velocity data signals received from a remote satellite system in light of an allowable tolerance. The system will detect changes in the vehicle such as tire size or tampering with the vehicles on-board measurement devices. The system may communicate out of tolerance conditions to the vehicle operator and the fleet manager.

Abstract: A method of providing a vehicle monitoring system for ensuring accurate vehicle mileage readings. A comparison is made between velocity measurements from several sources to detect unauthorized modifications made to a vehicle in an effort to ensure accurate vehicle odometer readings. The vehicle velocity measured on-board is compared with vehicle velocity data signals received from a remote satellite system in light of an allowable tolerance. The system will detect changes in the vehicle such as tire size or tampering with the vehicles on-board measurement devices. The system may communicate out of tolerance conditions to the vehicle operator and the fleet manager.

Abstract: A communications system for use in a vehicle that allows the user of the communications system to safely communicate from inside the vehicle. The communications system includes a memory for storing messages that will be transmitted by the driver to a receiving party, a sensor for sensing movement of the truck, a display unit coupled to the memory and the sensor for selectively displaying stored messages, a selector for selecting at least one stored message to be communicated to the receiving party, and a transmitter for transmitting the one or more stored messages. The display unit selectively displays the stored messages based on whether or not the vehicle is stopped preventing the operator from being distracted while driving.

Abstract: A method of providing a vehicle monitoring system for ensuring accurate vehicle mileage readings. A comparison is made between velocity measurements from several sources to detect unauthorized modifications made to a vehicle in an effort to ensure accurate vehicle odometer readings. The vehicle velocity measured on-board is compared with vehicle velocity data signals received from a remote satellite system in light of an allowable tolerance. The system will detect changes in the vehicle such as tire size or tampering with the vehicles on-board measurement devices. The system may communicate out of tolerance conditions to the vehicle operator and the fleet manager.