Patents by Inventor Brian A. Koss
Brian A. Koss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240084293Abstract: Cas-protein-ready tau biosensor cells, CRISPR/Cas synergistic activation mediator (SAM)-ready tau biosensor cells, and methods of making and using such cells to screen for genetic modifiers of tau seeding or aggregation are provided. Reagents and methods for sensitizing such cells to tau seeding activity or tau aggregation or for causing tau aggregation are also provided.Type: ApplicationFiled: November 6, 2023Publication date: March 14, 2024Applicant: Regeneron Pharmaceuticals, Inc.Inventors: Marine Prissette, Matthew Koss, Wen Fury, Brian Zambrowicz
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Publication number: 20240076613Abstract: BANF1, PPP2CA, and ANKLE2 were identified as genes that promote tau aggregation when disrupted. Improved tauopathy models such as cells, tissues, or animals having mutations in or inhibition of expression of BANF1 and/or PPP2CA and/or ANKLE2 are provided. Methods of using such improved tauopathy models for assessing therapeutic candidates for the treatment of a tauopathy, methods of making the improved tauopathy models, and methods of accelerating or exacerbating tau aggregation in a tauopathy model are also provided.Type: ApplicationFiled: November 6, 2023Publication date: March 7, 2024Applicant: Regeneron Pharmaceuticals, Inc.Inventors: Marine Prissette, Matthew Koss, Mathieu Desclaux, John McWhirter, Arijit Bhowmick, David Frendewey, Brian Zambrowicz, Claudia Racioppi
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Publication number: 20080316575Abstract: A method and system for correcting aberrations in a beam of light including correcting for effects from an undiffracted portion of an input beam. The method and system includes (1) a component for providing a beam of light; (2) a component for applying a diffraction grating pattern to the beam of light to establish an optical gradient to form an optical trap; (3) component for measuring aberration in the beam of light having the applied diffraction grating pattern; (4) component for calculating a phase-shifting diffraction grating encoding the aberration; and (5) component for projecting the phase-shifting diffraction grating in conjunction with the diffraction grating pattern characteristic of the optical trap.Type: ApplicationFiled: June 5, 2008Publication date: December 25, 2008Applicant: THE UNIVERSITY OF CHICAGO.,Inventors: Jennifer E. Curtis, Brian A. Koss, David G. Grier, Kosta Ladavac, Karen Kasza
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Patent number: 7176445Abstract: A method for creating large numbers of high-quality optical traps in arbitrary three-dimensional configurations and dynamically reconfiguring the traps under computer control. The method uses computer-generated diffractive optical elements to convert one or more optical tweezers into one or more optical vortices. The method involves combining the optical vortex technique with the holographic optical tweezer technique to create multiple optical vortices in arbitrary configurations. The method also involves employing the rotation induced in trapped particles by optical vortices to assemble clusters of particles into functional micromachines, to drive previously assembled micromachines, to pump fluids through microfluidics channels, to control flows of fluids through microfluidics channels, to mix fluids within microfluidics channels, to transport particles, to sort particles and to perform other related manipulations and transformations on matter over length scales.Type: GrantFiled: November 4, 2005Date of Patent: February 13, 2007Assignee: University of ChicagoInventors: Jennifer E. Curtis, Brian A. Koss, David G. Grier
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Patent number: 7104659Abstract: A method and apparatus for control of optical trap arrays and formation of particle arrays using light that is in the visible portion of the spectrum. The method and apparatus provides a laser and a time variable diffractive optical element to allow dynamic control of optical trap arrays and consequent control of particle arrays and also the ability to manipulate singular objects using a plurality of optical traps. By avoiding wavelengths associated with strong absorption in the underlying material, creating optical traps with a continuous-wave laser, optimizing the efficiency of individual traps, and trapping extended samples at multiple points, the rate of deleterious nonlinear optical processes can be minimized.Type: GrantFiled: December 10, 2004Date of Patent: September 12, 2006Assignee: University of ChicagoInventors: David G. Grier, Eric R. Dufresne, Jennifer E. Curtis, Brian A. Koss
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Patent number: 7075060Abstract: A method of use for holographic optical traps or gradients in which repetitive cycling of a small number of appropriately designed arrays of traps are used for general and very complex manipulations of particles and volumes of matter. Material transport results from a process resembling peristaltic pumping, with the sequence of holographically-defined trapping or holding manifolds resembling the states of a physical peristaltic pump.Type: GrantFiled: January 24, 2005Date of Patent: July 11, 2006Assignee: University of ChicagoInventors: David G. Grier, Sven Holger Behrens, Brian A. Koss
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Publication number: 20060054793Abstract: A method for creating large numbers of high-quality optical traps in arbitrary three-dimensional configurations and dynamically reconfiguring the traps under computer control. The method uses computer-generated diffractive optical elements to convert one or more optical tweezers into one or more optical vortices. The method involves combining the optical vortex technique with the holographic optical tweezer technique to create multiple optical vortices in arbitrary configurations.Type: ApplicationFiled: November 4, 2005Publication date: March 16, 2006Inventors: Jennifer Curtis, Brian Koss, David Grier
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Patent number: 6995351Abstract: A method for creating large numbers of high-quality optical traps in arbitrary three-dimensional configurations and dynamically reconfiguring the traps under computer control. The method uses computer-generated diffractive optical elements to convert one or more optical tweezers into one or more optical vortices. The method involves combining the optical vortex technique with the holographic optical tweezer technique to create multiple optical vortices in arbitrary configurations. The method also involves employing the rotation induced in trapped particles by optical vortices to assemble clusters of particles into functional micromachines, to drive previously assembled micromachines, to pump fluids through microfluidics channels, to control flows of fluids through microfluidics channels, to mix fluids within microfluidics channels, to transport particles, to sort particles and to perform other related manipulations and transformations on matter over length scales.Type: GrantFiled: February 17, 2005Date of Patent: February 7, 2006Assignee: The University of ChicagoInventors: Jennifer E. Curtis, Brian A. Koss, David G. Grier
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Publication number: 20050173622Abstract: A method for creating large numbers of high-quality optical traps in arbitrary three-dimensional configurations and dynamically reconfiguring the traps under computer control. The method uses computer-generated diffractive optical elements to convert one or more optical tweezers into one or more optical vortices. The method involves combining the optical vortex technique with the holographic optical tweezer technique to create multiple optical vortices in arbitrary configurations.Type: ApplicationFiled: February 17, 2005Publication date: August 11, 2005Inventors: Jennifer Curtis, Brian Koss, David Grier
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Publication number: 20050098717Abstract: A method and apparatus for control of optical trap arrays and formation of particle arrays using light that is in the visible portion of the spectrum. The method and apparatus provides a laser and a time variable diffractive optical element to allow dynamic control of optical trap arrays and consequent control of particle arrays and also the ability to manipulate singular objects using a plurality of optical traps. By avoiding wavelengths associated with strong absorption in the underlying material, creating optical traps with a continuous-wave laser, optimizing the efficiency of individual traps, and trapping extended samples at multiple points, the rate of deleterious nonlinear optical processes can be minimized.Type: ApplicationFiled: December 10, 2004Publication date: May 12, 2005Inventors: David Grier, Eric Dufresne, Jennifer Curtis, Brian Koss
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Patent number: 6858833Abstract: A method for creating large numbers of high-quality optical traps in arbitrary three-dimensional configurations and dynamically reconfiguring the traps under computer control. The method uses computer-generated diffractive optical elements to convert one or more optical tweezers into one or more optical vortices. The method involves combining the optical vortex technique with the holographic optical tweezer technique to create multiple optical vortices in arbitrary configurations. The method also involves employing the rotation induced in trapped particles by optical vortices to assemble clusters of particles into functional micromachines, to drive previously assembled micromachines, to pump fluids through microfluidics channels, to control flows of fluids through microfluidics channels, to mix fluids within microfluidics channels, to transport particles, to sort particles and to perform other related manipulations and transformations on matter over length scales.Type: GrantFiled: May 17, 2004Date of Patent: February 22, 2005Assignee: University of ChicagoInventors: Jennifer E. Curtis, Brian A. Koss, David G. Grier
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Patent number: 6846084Abstract: A method and apparatus for control of optical trap arrays and formation of particle arrays using light that is in the visible portion of the spectrum. The method and apparatus provides a laser and a time variable diffractive optical element to allow dynamic control of optical trap arrays and consequent control of particle arrays and also the ability to manipulate singular objects using a plurality of optical traps. By avoiding wavelengths associated with strong absorption in the underlying material, creating optical traps with a continuous-wave laser, optimizing the efficiency of individual traps, and trapping extended samples at multiple points, the rate of deleterious nonlinear optical processes can be minimized.Type: GrantFiled: August 22, 2003Date of Patent: January 25, 2005Assignee: University of ChicagoInventors: David G. Grier, Eric R. Dufresne, Jennifer E. Curtis, Brian A. Koss
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Publication number: 20040211889Abstract: A method for creating large numbers of high-quality optical traps in arbitrary three-dimensional configurations and dynamically reconfiguring the traps under computer control. The method uses computer-generated diffractive optical elements to convert one or more optical tweezers into one or more optical vortices. The method involves combining the optical vortex technique with the holographic optical tweezer technique to create multiple optical vortices in arbitrary configurations.Type: ApplicationFiled: May 17, 2004Publication date: October 28, 2004Applicant: The University of ChicagoInventors: Jennifer E. Curtis, Brian A. Koss, David G. Grier
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Patent number: 6737634Abstract: A method for creating large numbers of high-quality optical traps in arbitrary three-dimensional configurations and dynamically reconfiguring the traps under computer control. The method uses computer-generated diffractive optical elements to convert one or more optical tweezers into one or more optical vortices. The method involves combining the optical vortex technique with the holographic optical tweezer technique to create multiple optical vortices in arbitrary configurations.Type: GrantFiled: January 16, 2002Date of Patent: May 18, 2004Assignee: The University of ChicagoInventors: Jennifer E. Curtis, Brian A. Koss, David G. Grier
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Publication number: 20040036976Abstract: A method and apparatus for control of optical trap arrays and formation of particle arrays using light that is in the visible portion of the spectrum. The method and apparatus provides a laser and a time variable diffractive optical element to allow dynamic control of optical trap arrays and consequent control of particle arrays and also the ability to manipulate singular objects using a plurality of optical traps. By avoiding wavelengths associated with strong absorption in the underlying material, creating optical traps with a continuous-wave laser, optimizing the efficiency of individual traps, and trapping extended samples at multiple points, the rate of deleterious nonlinear optical processes can be minimized.Type: ApplicationFiled: August 22, 2003Publication date: February 26, 2004Applicant: University of ChicagoInventors: David G. Grier, Eric R. Dufresne, Jennifer E. Curtis, Brian A. Koss
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Patent number: 6626546Abstract: A method and apparatus for control of optical trap arrays and formation of particle arrays using light that is in the visible portion of the spectrum. The method and apparatus provides a laser and a time variable diffractive optical element to allow dynamic control of optical trap arrays and consequent control of particle arrays and also the ability to manipulate singular objects using a plurality of optical traps. By avoiding wavelengths associated with strong absorption in the underlying material, creating optical traps with a continuous-wave laser, optimizing the efficiency of individual traps, and trapping extended samples at multiple points, the rate of deleterious nonlinear optical processes can be minimized.Type: GrantFiled: July 1, 2002Date of Patent: September 30, 2003Assignee: University of ChicagoInventors: David G. Grier, Eric R. Dufresne, Jennifer E. Curtis, Brian A. Koss
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Publication number: 20030132373Abstract: A method for creating large numbers of high-quality optical traps in arbitrary three-dimensional configurations and dynamically reconfiguring the traps under computer control. The method uses computer-generated diffractive optical elements to convert one or more optical tweezers into one or more optical vortices. The method involves combining the optical vortex technique with the holographic optical tweezer technique to create multiple optical vortices in arbitrary configurations.Type: ApplicationFiled: January 16, 2002Publication date: July 17, 2003Inventors: Jennifer E. Curtis, Brian A. Koss, David G. Grier
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Publication number: 20020181113Abstract: A method and apparatus for control of optical trap arrays and formation of particle arrays using light that is in the visible portion of the spectrum. The method and apparatus provides a laser and a time variable diffractive optical element to allow dynamic control of optical trap arrays and consequent control of particle arrays and also the ability to manipulate singular objects using a plurality of optical traps. By avoiding wavelengths associated with strong absorption in the underlying material, creating optical traps with a continuous-wave laser, optimizing the efficiency of individual traps, and trapping extended samples at multiple points, the rate of deleterious nonlinear optical processes can be minimized.Type: ApplicationFiled: July 1, 2002Publication date: December 5, 2002Applicant: University of ChicagoInventors: David G. Grier, Eric R. Dufresne, Jennifer E. Curtis, Brian A. Koss