Patents by Inventor Brian A. Lanman

Brian A. Lanman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF
    Publication number: 20260132143
    Abstract: The present disclosure provides compounds having activity as inhibitors of the G12C mutant KRAS protein, pharmaceutical compositions comprising the compounds, and methods of treating certain disorders, such as cancer, including but not limited to lung, pancreatic, and colorectal cancer. In particular, the disclosure provides compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein the substituents arm as described.
    Type: Application
    Filed: October 5, 2023
    Publication date: May 14, 2026
    Applicant: AMGEN INC.
    Inventors: BRIAN A. LANMAN, SHON BOOKER, JOHN R. BUTLER, EMIL GLIBSTRUP, DAVID HUANG, BIRGITTE W. HUSEMOEN, MATTHEW R. KALLER, TODD J. KOHN, SEBASTIAN LETH-PETERSEN, PATRICIA LOPEZ, QINGYIAN LIU, VU VAN MA, FRANCESCO MANONI, JORGE PEIRO CADAHIA, ALEXANDER J. PICKRELL, SLAVKO RAST, NURIA A. TAMAYO, HUI-LING WANG, WENHAN ZHANG, KAI ZHU, ABHISEK BANERJEE
  • Amides as pim inhibitors
    Patent number: 9394297
    Abstract: The invention relates to amide-containing compounds of formula (1), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
    Type: Grant
    Filed: February 27, 2013
    Date of Patent: July 19, 2016
    Assignee: AMGEN INC.
    Inventors: Victor Cee, Frank Chavez, Jr., Jian J. Chen, Essa Hu Harrington, Bradley Herberich, Claire L. M. Jackson, Brian A. Lanman, Thomas T. Nguyen, Mark H. Norman, Liping H. Pettus, Anthony B. Reed, Adrian L. Smith, Nuria A. Tamayo, Andrew Tasker, Hui-Ling Wang, Bin Wu, Ryan Wurz
  • AMIDES AS PIM INHIBITORS
    Publication number: 20150329538
    Abstract: The invention relates to amide-containing compounds of formula (1), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
    Type: Application
    Filed: February 27, 2013
    Publication date: November 19, 2015
    Applicant: AMGEN INC.
    Inventors: Victor CEE, Frank CHAVEZ, JR., Jian J. CHEN, Essa Hu HARRINGTON, Bradley HERBERICH, Claire L.M. JACKSON, Brian A. LANMAN, Thomas T. NGUYEN, Mark H. NORMAN, Liping H. PETTUS, Anthony B. REED, Adrian L. SMITH, Nuria A. TAMAYO, Andrew TASKER, Hui-Ling WANG, Bin WU, Ryan WURZ
  • Bicyclic compounds as Pim inhibitors
    Patent number: 9090593
    Abstract: The invention relates to bicyclic compounds of formula (1?), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: July 28, 2015
    Assignee: AMGEN INC.
    Inventors: Hui-Ling Wang, Kaustav Biswas, Victor J. Cee, Frank Chavez, Jr., Bradley J. Herberich, Claire L. M. Jackson, Brian A. Lanman, Matthew Lee, Thomas Nixey, Liping H. Pettus, Anthony B. Reed, Robert M. Rzasa, Shannon Rumfelt, Andrew Tasker, Bin Wu, Ryan Wurz
  • BICYCLIC COMPOUNDS AS PIM INHIBITORS
    Publication number: 20140031360
    Abstract: The invention relates to bicyclic compounds of formula (1?), and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.
    Type: Application
    Filed: December 7, 2011
    Publication date: January 30, 2014
    Applicant: AMGEN INC.
    Inventors: Hui-Ling Wang, Kaustav Biswas, Victor J. Cee, Frank Chavez, JR., Bradley J. Herberich, Claire L.M. Jackson, Brian A. Lanman, Matthew Lee, Thomas Nixey, Liping H. Pettus, Anthony B. Reed, Robert M. Rzasa, Shannon Rumfelt, Andrew Tasker, Bin Wu, Ryan Wurz
  • INHIBITORS OF PI3 KINASE AND/OR MTOR
    Publication number: 20100273764
    Abstract: The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein the variables are as defined herein.
    Type: Application
    Filed: April 27, 2010
    Publication date: October 28, 2010
    Applicant: Amgen Inc.
    Inventors: Kristin Andrews, Yunxin Y. Bo, Shon Booker, Victor J. Cee, Noel D'Angelo, Bradley J. Herberich, Fang-Tsao Hong, Claire L.M. Jackson, Brian A. Lanman, Hongyu Liao, Longbin Liu, Nobuko Nishimura, Mark H. Norman, Liping H. Pettus, Anthony B. Reed, Adrian L. Smith, Seifu Tadesse, Nuria A. Tamayo, Bin Wu, Ryan Wurz, Kevin Yang