Patents by Inventor Brian A. Sparling

Brian A. Sparling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hyperforin analogs, methods of synthesis, and uses thereof
    Patent number: 9321713
    Abstract: The present invention provides a novel 11-step enantioselective approach to the natural product hyperforin, which enables access to a wide variety of hyperforin analogs. The present invention also provides pharmaceutical compositions comprising inventive hyperforin analogs. Hyperforin analogs synthesized using the present synthetic method are envisioned useful in the treatment of various conditions, including, but not limited to, depression and conditions characterized by depression, inflammatory skin conditions, diabetes, asthma, chronic obstructive pulmonary disease (COPD), kidney disorders, and ischemic brain damage.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: April 26, 2016
    Assignee: President and Fellows of Harvard College
    Inventors: Matthew D. Shair, Brian A. Sparling, David Moebius
  • HYPERFORIN ANALOGS, METHODS OF SYNTHESIS, AND USES THEREOF
    Publication number: 20140135287
    Abstract: The present invention provides a novel 11-step enantioselective approach to the natural product hyperforin, which enables access to a wide variety of hyperforin analogs. The present invention also provides pharmaceutical compositions comprising inventive hyperforin analogs. Hyperforin analogs synthesized using the present synthetic method are envisioned useful in the treatment of various conditions, including, but not limited to, depression and conditions characterized by depression, inflammatory skin conditions, diabetes, asthma, chronic obstructive pulmonary disease (COPD), kidney disorders, and ischemic brain damage.
    Type: Application
    Filed: June 1, 2012
    Publication date: May 15, 2014
    Applicant: President and Fellows of Harvard College
    Inventors: Matthew D. Shair, Brian A. Sparling, David Moebius