Abstract: Described herein are compounds that inhibit ALK2 and its mutants, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.

Abstract: Systems and methods for casting solid propellants include a mandrel for forming geometric features in a perforation of a propellant grain. In various embodiments, the mandrel includes a frangible portion that is removed from the propellant grain after the propellant grain has cured around the mandrel. A second portion of the mandrel may be left behind in the propellant grain. The mandrel may include a support structured disposed in the through hole of the mandrel. The support structure may include a plurality of longitudinal channels for directed exhaust gasses through the mandrel upon ignition of the propellant grain.

Abstract: A system may determine one or more data sources which the system is configured to access. The system may provide a set of application programming interfaces (APIs) for interacting with data stored in one or more data sources. The APIs may be accessible to one or more web applications which the system is configured to serve. The system may determine that a web application has requested an operation for interacting with the data through one or more APIs in the set of APIs. The system may determine one or more responses based at least in part on the operation requested by the web application. The system may provide the response(s) to the web application.

Abstract: A vibration dampening system includes a vibration dampening element for a turbine nozzle or blade. A body opening extends through the turbine nozzle or blade, e.g., through the airfoil among potentially other parts of the nozzle or blade. A vibration dampening element includes a plurality of stacked damper pins within the body opening. The damper pins include an outer body having an inner opening, a first end surface and an opposing second end surface; and an inner body nested and movable within the inner opening of the outer body. The end surfaces frictionally engage to dampen vibration. The inner body has a first central opening including a first portion configured to engage an elongated body therein and an outer surface configured to frictionally engage a portion of the inner opening of the outer body to dampen vibration.

Abstract: A method of processing a transaction between a customer and a merchant includes receiving from a mobile device of the customer or from another device of the customer an indication of consent to perform a cardless payment transaction with the merchant, receiving from the mobile device an indication that the customer is within a predetermined distance of the merchant, after receiving both the indication of consent and the indication that the customer is within the predetermined distance, sending to a computer system of the merchant an indication of the presence of the customer and personal identifying information for the customer, receiving data indicating a transaction between the customer and the merchant, and submitting the transaction to a financial service for authorization.

Abstract: A hybrid tree and network visualization represents a segmented computer network. The visualization presents an overview of the segmentation as a hierarchy and displays connections within the network. Using the visualization, analysts can explore a segmented network, identify nodes and connections of interest through exploratory network analysis, and drill down on elements of interest to reason about the patterns of relationships in the network. Thus, analysts can intuitively obtain a deeper understanding of the network to identify potential security threats and other problems as well as write better segmentation policies.

Abstract: An example outdoor mounted device includes a first battery configured to operate at a low temperature range that at least includes negative 20 Celsius; a second battery configured to operate at a high temperature range; a temperature sensor; and processing circuitry configured to: determine, based on data received from the temperature sensors, a current temperature; responsive to determining that the current temperature is within the low temperature range, cause one or more components of the computing device to operate using electrical energy sourced from the first battery; and responsive to determining that the current temperature is within the high temperature range, cause the one or more components of the computing device to operate using electrical energy sourced from the second battery.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for transferring money using email. One of the methods includes receiving a user input of a funds-transfer request from a sender associated with a first identifier to one or more recipients associated with one or more second identifiers, respectively, generating one or more electronic messages based on the user input, each being operable to allow a respective recipient to send a funds-transfer authorization, sending the electronic messages to the recipients based on the second identifiers, receiving one or more funds-transfer authorizations from the one or more recipients, respectively, identifying a sender account based on the first identifier and one or more recipient accounts based on the one or more second identifiers, respectively; and initiating one or more transfers of funds from the one or more recipient accounts to the sender account, respectively.

Abstract: The present disclosure provides embodiments of a sticker dispenser including a dispenser body. The dispenser body defines an inner cavity arranged along a longitudinal axis. A pusher member is disposed within the cavity and extends along the longitudinal axis. A sticker cartridge is movable within the dispenser body along the longitudinal axis, and an outside surface of cartridge is shaped to fit into the inner cavity. A plurality of stickers are arranged in a stack and disposed within the cartridge. Each sticker includes an adhesive surface and a non-adhesive surface. A bottommost sticker is arranged at a distal end of the cartridge and a topmost sticker is arranged within the cartridge proximal of the bottommost sticker.

Abstract: Precursor solutions for radiation patternable coatings are formed with an organic solvent and monoalkyl tin trialkoxides in which the water content of the solvent is adjusted to be within 10 percent of a selected value. Generally, the water content of the solvent is adjusted through water addition, although water removal can also be used. In some embodiments, the adjusted water content of the solvent can be from about 250 ppm by weight to about 10,000 ppm by weight. With the appropriate selection of ligands, the adjusted precursor solutions can be stable for at least about 42 days, and in some cases at least 8 months.

Abstract: An implantable device for intratumoral delivery of a therapeutic agent is provided. The implantable device includes a polymer matrix within which is dispersed a pharmaceutical formulation that includes one or more therapeutic agents. The therapeutic agent(s) includes one or more antibodies. Optionally, the polymer matrix includes one or more excipients. The polymer matrix includes a hydrophobic polymer. The hydrophobic polymer has a melt flow index of from about 0.2 to about 100 grams per 10 minutes as determined in accordance with ASTM D1238-20 at a temperature of 190° C. and a load of 2.16 kilograms and/or a melting temperature of from about 20° C. to about 70° C. as determined in accordance with ASTM D3418-21.

Abstract: An apparatus comprises a storage device and a device controller operatively coupled with the storage device. The device controller comprises a memory that stores an application. The application stored on the memory comprises instructions. When executed, the instruction direct the device controller to receive a storage request comprising content. The device controller retrieves a storage device policy from the memory that indicates a set of storage locations on the storage device. The device controller selects one of the storage locations on the storage device based on the storage device policy. The device controller stores the content on the storage device at the selected storage location. The device controller records storage information for the content that indicates the selected location on the memory.

Abstract: Reduced-size user interfaces for providing weather information are disclosed. At an electronic device with a touch-sensitive display, indications of a location and a temperature at the location may be displayed. In some examples, a user may provide input through a touch on the touch-sensitive display and/or through a rotation of a rotatable input mechanism to display additional weather information, such as weather information for another location, another temperature, another time, and so forth. In some examples, the device may obtain data representing an upcoming activity, determine whether the activity is to begin within a threshold amount of time, and display weather information based on the upcoming activity. In some examples, the device may display an affordance at a position to indicate the time of day for which a weather condition is provided.

Abstract: In an embodiment, a storage device is provided. A device controller with a memory is coupled with the storage device. The memory stores an application with instructions that direct the controller to receive a storage device policy. The instructions further direct the controller to store content from a storage request in accordance with the storage device policy, and record storage information, including at least a content identifier, to the memory. Subsequent to storing the content, the instructions further direct the controller to retrieve the content according to the storage information received in a storage request. According to an implementation, the instructions further provide instruction to refuse a delete request in accordance with the storage information. According to an implementation, the instructions provide direction to store the storage information at a remote location.

Abstract: A solid propellant propulsion motor may comprise: a forward propellant grain extending along a longitudinal axis of a motor case between a forward end of the motor case and a first burn inhibitor layer in the motor case; the first burn inhibitor layer disposed axially adjacent to the forward propellant grain; an aft propellant grain disposed axially adjacent to the first burn inhibitor layer; a second burn inhibitor layer disposed axially adjacent to an aft end of the aft propellant grain; and an ablative material layer disposed on a radially inner surface of the aft propellant grain.

Abstract: Systems and methods for casting solid propellants include a mandrel for forming geometric features in a perforation of a propellant grain. In various embodiments, the mandrel includes a frangible portion that is removed from the propellant grain after the propellant grain has cured around the mandrel. A second portion of the mandrel may be left behind in the propellant grain. The mandrel may include a support structured disposed in the through hole of the mandrel. The support structure may include a plurality of longitudinal channels for directed exhaust gasses through the mandrel upon ignition of the propellant grain.

Abstract: A method includes receiving data images of patient medications. The method also creates a training set using the received data images. The method also includes training a machine learning system using the training set. The machine learning system is trained to monitor shipment and inventory of the patient medications, patient enrollment in medical trials, and a distribution of the patient medications. The method also includes applying the trained machine learning system with monitoring results of the shipment and inventory of the patient medications, the patient enrollment in the medical trials, and the distribution of the patient medications.

Abstract: A photodynamic therapy apparatus for local targeting in cancer treatment capable of treating various types of cancers or tumors. An endoscope is placed in the center of an end portion of a probe used in photodynamic therapy and a plurality of optical fibers are arranged along the edge thereof, so that a lesion site is irradiated with a plurality of lights while the plurality of optical fibers of the probe receive lights from individual light sources, respectively, to perform light irradiation individually. An apparatus is disclosed, wherein unnecessary damage to normal tissues is minimized by controlling light irradiation regions, for instance, by defining light irradiation regions encompassing a lesion site from an image provided in real time through an endoscope disposed at an end portion of a probe and allowing only individual light sources irradiating the defined light irradiation regions to emit lights to achieve local light irradiation.

Abstract: An implantable medical device is provided. The core includes a core polymer matrix within which is dispersed a therapeutic agent comprising one or more aromatase inhibitors. The core polymer matrix contains an ethylene vinyl acetate copolymer. The ethylene vinyl acetate copolymer has a melting temperature of from about 40° C. to about 120° C. as determined in accordance with ASTM D3418-15.

Abstract: An intravaginal ring device is provided. The core includes a core polymer matrix within which is dispersed a therapeutic agent comprising one or more aromatase inhibitors. The core polymer matrix contains an ethylene vinyl acetate copolymer. The ethylene vinyl acetate copolymer has a vinyl acetate content of from about 10 wt. % to about 60 wt. % and/or a melting temperature of from about 40° C. to about 120° C. as determined in accordance with ASTM D3418-15.