Abstract: The disclosure includes systems comprising non-viral DNA vectors encapsulated in lipid vesicles that are designed to achieve sustained therapeutically relevant expression levels in blood plasma of therapeutic proteins, polypeptides, or peptides. The system can express antibodies or antigen-binding fragments at sustained and therapeutically relevant levels. The system can be administered to a subject via local or systemic routes such as intravenous (IV) or intramuscular (IM), and repeat dosing produces an additive effect. For local administration, localized expression can be achieved. Applications span treatments for various conditions, including infectious diseases, cancers, and inflammatory diseases.

Abstract: The present disclosure relates to systems for the expression of antibodies or antigen binding fragments in a subject, as well as methods of treatments of diseases therewith.