Patents by Inventor Brian Alan Lanman

Brian Alan Lanman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Apelin polypeptides
    Patent number: 12679868
    Abstract: The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.
    Type: Grant
    Filed: October 30, 2023
    Date of Patent: July 14, 2026
    Assignee: AMGEN INC.
    Inventors: Jerry Ryan Holder, Gayathri Swaminath, Michael J. Frohn, Brian Alan Lanman, Anthony B. Reed, Leslie P. Miranda, John Gordon Allen, Alexander J. Pickrell, Aaron C. Siegmund, Lewis D. Pennington, Bryant Yang
  • MACROCYCLIC COMPOUNDS AND METHODS OF USE
    Publication number: 20260174769
    Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S, G13D, Q61H, Q61L or G12C. The compounds have a general Formula I? (I?) wherein the variables of Formula I? are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.
    Type: Application
    Filed: November 14, 2023
    Publication date: June 25, 2026
    Applicant: AMGEN INC.
    Inventors: Ryan Paul Wurz, Yunxiao LI, Primali Vasundera NAVARATNE, Jose M. MEDINA, Ning CHEN, Liping PETTUS, Xiaofen LI, John STELLWAGEN, Kexue LI, Brian Alan LANMAN, Michael M. YAMANO, Wei ZHAO, Benjamin WIGMAN, Albert K. AMEGADZIE, Fabien EMMETIERE, Christopher P. MOHR, Aaron C. SIEGMUND, Rene RAHIMOFF, Zhichen WU, Adriano BAUER, Andrew SMALIGO, Quentin Tercenio, Qingyian Liu, Shon K. Booker, Jeffrey Jackson
  • KRAS G12C inhibitors and methods of using the same
    Patent number: 12583854
    Abstract: Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
    Type: Grant
    Filed: September 22, 2021
    Date of Patent: March 24, 2026
    Assignee: Amgen Inc.
    Inventors: Jian Chen, Nuria A. Tamayo, Longbin Liu, Hui-Ling Wang, Brian Alan Lanman, Ryan Paul Wurz, Youngsook Shin, Victor J. Cee
  • Macrocyclic compounds and methods of use
    Patent number: 12570672
    Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S, G13D, Q61H, Q61L or G12C. The compounds have a general Formula I?: wherein the variables of Formula I? are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.
    Type: Grant
    Filed: March 25, 2024
    Date of Patent: March 10, 2026
    Inventors: Ryan Paul Wurz, Yunxiao Li, Liping Pettus, Brian Alan Lanman, Michael M. Yamano, Wei Zhao, Benjamin Wigman, Adriano Bauer, Andrew Smaligo, Shon K. Booker, John Stellwagen
  • KRAS G12C INHIBITORS AND METHODS OF USING THE SAME
    Publication number: 20250381187
    Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
    Type: Application
    Filed: August 27, 2025
    Publication date: December 18, 2025
    Applicant: AMGEN INC.
    Inventors: John Gordon ALLEN, Jennifer Rebecca ALLEN, Ana Elena MINATTI, Qiufen XUE, Ryan Paul WURZ, Christopher M. TEGLEY, Alexander J. PICKRELL, Thomas T. NGUYEN, Vu Van MA, Patricia LOPEZ, Longbin LIU, David John KOPECKY, Michael J. FROHN, Ning CHEN, Jian Jeffrey CHEN, Aaron C. SIEGMUND, Albert K. AMEGADZIE, Shon BOOKER, Clifford GOODMAN, Nuria A. TAMAYO, Mary WALTON, Nobuko NISHIMURA, Youngsook SHIN, Jonathan Dante LOW, Victor J. CEE, Anthony B. REED, Hui-Ling WANG, Brian Alan LANMAN
  • KRAS G12C INHIBITORS AND METHODS OF USING THE SAME
    Publication number: 20250362134
    Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
    Type: Application
    Filed: June 24, 2025
    Publication date: November 27, 2025
    Applicant: AMGEN INC.
    Inventors: Brian Alan LANMAN, Victor J. CEE, Alexander J. PICKRELL, Anthony B. REED, Kevin C. YANG, David John KOPECKY, Hui-Ling WANG, Patricia LOPEZ, Kate ASHTON, Shon BOOKER, Christopher M. TEGLEY
  • KRAS G12C inhibitors and methods of using the same
    Patent number: 12440491
    Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
    Type: Grant
    Filed: June 23, 2023
    Date of Patent: October 14, 2025
    Assignee: Amgen Inc.
    Inventors: John Gordon Allen, Jennifer Rebecca Allen, Ana Elena Minatti, Qiufen Xue, Ryan Paul Wurz, Christopher M. Tegley, Alexander J. Pickrell, Thomas T. Nguyen, Vu Van Ma, Patricia Lopez, Longbin Liu, David John Kopecky, Michael J. Frohn, Ning Chen, Jian Jeffrey Chen, Aaron C. Siegmund, Albert Amegadzie, Nuria A. Tamayo, Shon Booker, Clifford Goodman, Mary Walton, Nobuko Nishimura, Youngsook Shin, Jonathan D. Low, Victor J. Cee, Anthony B. Reed, Hui-Ling Wang, Brian Alan Lanman
  • MACROCYCLIC COMPOUNDS AND METHODS OF USE
    Publication number: 20250304599
    Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S, G13D, Q61H, Q61L or G12C. The compounds have a general Formula I?: wherein the variables of Formula I? are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.
    Type: Application
    Filed: October 30, 2024
    Publication date: October 2, 2025
    Applicant: AMGEN INC.
    Inventors: Ryan Paul Wurz, Yunxiao LI, Primali Vasundera NAVARATNE, Jose M. MEDINA, Ning CHEN, Liping PETTUS, Xiaofen LI, John STELLWAGEN, Kexue LI, Brian Alan LANMAN, Michael M. YAMANO, Wei ZHAO, Benjamin WIGMAN, Fabien EMMETIERE, Albert K. AMEGADZIE, Christopher P. MOHR, Aaron C. SIEGMUND, Rene RAHIMOFF, Zhichen WU, Adriano BAUER, Andrew SMALIGO, Quentin Tercenio, Qingyian Liu, Shon K. Booker, Jeffrey Jackson
  • MACROCYCLIC COMPOUNDS AND METHODS OF USE
    Publication number: 20250236631
    Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S, G13D, Q61H, Q61L or G12C. The compounds have a general Formula I?: wherein the variables of Formula I? are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.
    Type: Application
    Filed: April 11, 2025
    Publication date: July 24, 2025
    Applicant: AMGEN INC.
    Inventors: Ryan Paul Wurz, Yunxiao LI, Primali Vasundera NAVARATNE, Jose M. MEDINA, Ning CHEN, Liping PETTUS, Xiaofen LI, John STELLWAGEN, Kexue LI, Brian Alan LANMAN, Michael M. YAMANO, Wei ZHAO, Benjamin WIGMAN, Fabien EMMETIERE, Albert K. AMEGADZIE, Christopher P. MOHR, Aaron C. SIEGMUND, Rene RAHIMOFF, Zhichen WU, Adriano BAUER, Andrew SMALIGO, Quentin Tercenio, Qingyian Liu, Shon K. Booker, Jeffrey Jackson
  • QUINAZOLINE COMPOUNDS AND USES THEREOF AS INHIBITORS OF MUTANT KRAS PROTEINS
    Publication number: 20250179077
    Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S or G12C. The compounds have a general Formula (I): (Formula (I)) wherein the variables of Formula (I) are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.
    Type: Application
    Filed: February 15, 2023
    Publication date: June 5, 2025
    Applicant: AMGEN INC.
    Inventors: Brian Alan Lanman, Ryan Paul Wurz, Wei Zhao, Xiaofen LI, Imelda HOT, Rene RAHIMOFF, Liping Pettus, Ning Chen, Fabien EMMETIERE, Jeffery Jackson, Yunxiao LI, Francesco Manoni, Primali Navaratne, Andrew Smaligo, John Charles Stellwagen, John Allen
  • QUINAZOLINE COMPOUNDS AND USES THEREOF AS INHIBITORS OF MUTANT KRAS PROTEINS
    Publication number: 20250163064
    Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S or G12C. The compounds have a general Formula I: (I) wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.
    Type: Application
    Filed: February 15, 2023
    Publication date: May 22, 2025
    Applicant: AMGEN INC.
    Inventors: Brian Alan Lanman, Ryan Paul Wurz, Wei Zhao, Xiaofen LI, Michael YAMANO, Imelda HOT, Rene RAHIMOFF, Liping Pettus, Jose Medina
  • HETEROCYCLIC COMPOUNDS AND METHODS OF USE
    Publication number: 20250122222
    Abstract: The present disclosure provides compounds useful for the inhibition of KRAS. The compounds have a general Formula I: wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.
    Type: Application
    Filed: August 10, 2022
    Publication date: April 17, 2025
    Applicant: AMGEN INC.
    Inventors: Michael M. YAMANO, Yunxiao LI, Primali Vasundera NAVARATNE, Jose M. MEDINA, Ning CHEN, Liping PETTUS, Rene RAHIMOFF, Xiaofen LI, John STELLWAGEN, Francesco MANONI, Kexue LI, Brian Alan LANMAN, Ryan Paul Wurz, Wei ZHAO, Huan RUI, Josephine ESHON
  • Heterocyclic Compounds and Methods of Use
    Publication number: 20250059205
    Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D. The compounds have a general Formula I: (I) wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.
    Type: Application
    Filed: April 28, 2022
    Publication date: February 20, 2025
    Applicant: AMGEN INC.
    Inventors: Brian Alan Lanman, Ryan Paul Wurz, Wei Zhao, Xiaofen Li, Michael M. Yamano, Yunxiao Li, Ning Chen, Birgitte Weinreich Husemoen, Sebastian Leth-Petersen, Jose M. Medina, Kexue Li, Liping Pettus, Rene Rahimoff, Primali Vasundera Navaratne, Huan Rui, Christopher P. Mohr
  • KRAS G12C INHIBITORS AND METHODS OF USING THE SAME
    Publication number: 20250057817
    Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
    Type: Application
    Filed: February 16, 2024
    Publication date: February 20, 2025
    Applicant: AMGEN INC.
    Inventors: Brian Alan LANMAN, Victor J. CEE, Alexander J. PICKRELL, Anthony B. REED, Kevin C. YANG, David John KOPECKY, Hui-Ling WANG, Patricia LOPEZ, Kate ASHTON, Shon BOOKER, Christopher M. TEGLEY
  • Heterocyclic Compounds and Methods of Use
    Publication number: 20250059179
    Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D. The compounds have a general Formula I: (I) wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.
    Type: Application
    Filed: April 28, 2022
    Publication date: February 20, 2025
    Applicant: AMGEN INC.
    Inventors: Brian Alan Lanman, Ryan Paul Wurz, Wei Zhao, Xiaofen Li, Michael M. Yamano, Yunxiao Li, Ning Chen, Sebastian Leth-Petersen, Kexue Li, Liping Pettus, Rene Rahimoff, Primali Vasundera Navaratne, Huan Rui
  • HETEROCYCLIC COMPOUNDS AND METHODS OF USE
    Publication number: 20250034167
    Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D. The compounds have a general Formula (I): wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.
    Type: Application
    Filed: August 10, 2022
    Publication date: January 30, 2025
    Applicant: AMGEN INC.
    Inventors: Michael M. YAMANO, Yunxiao LI, Primali Vasundera NAVARATNE, Jose M. MEDINA, Ning CHEN, Liping PETTUS, Rene RAHIMOFF, Xiaofen LI, John STELLWAGEN, Francesco MANONI, Kexue LI, Brian Alan LANMAN, Ryan Paul Wurz, Wei ZHAO, Huan RUI, Josephine ESHON
  • HETEROCYCLIC COMPOUNDS AND METHODS OF USE
    Publication number: 20240417412
    Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D. The compounds have a general Formula I: wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.
    Type: Application
    Filed: August 10, 2022
    Publication date: December 19, 2024
    Applicant: AMGEN INC.
    Inventors: Brian Alan Lanman, Wei Zhao, Ryan Paul Wurz, Primali Vasundera NAVARATNE, Liping PETTUS, Michael M. YAMANO, Ning Chen, Rene RAHIMOFF, Francesco MANONI, John STELLWAGEN
  • APELIN POLYPEPTIDES
    Publication number: 20240327461
    Abstract: The invention provides modified apelin polypeptides having increased stability, circulating half-life, and/or potency relative to the native apelin-13 polypeptide. Compositions comprising the modified apelin polypeptides and methods of using the polypeptides for treating cardiac disorders, such as heart failure, are also disclosed.
    Type: Application
    Filed: June 11, 2024
    Publication date: October 3, 2024
    Applicant: AMGEN INC.
    Inventors: Jerry Ryan HOLDER, Gayathri SWAMINATH, Michael J. FROHN, Brian Alan LANMAN, Anthony B. REED, Leslie P. MIRANDA, John Gordon ALLEN, Alexander J. PICKRELL, Aaron C. SIEGMUND, Lewis D. PENNINGTON, Bryant YANG
  • Substituted piperazines as KRAS G12C inhibitors
    Patent number: 12083121
    Abstract: Provided herein are KRAS G12C inhibitors, such as composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.
    Type: Grant
    Filed: January 19, 2022
    Date of Patent: September 10, 2024
    Assignee: Amgen Inc.
    Inventors: John Gordon Allen, Brian Alan Lanman, Jian Chen, Anthony B. Reed, Victor J. Cee, Longbin Liu, Patricia Lopez, Ryan Paul Wurz, Thomas T. Nguyen, Shon Booker, Jennifer Rebecca Allen, Margaret Chu-Moyer, Albert Amegadzie, Ning Chen, Clifford Goodman, Jonathan D. Low, Vu Van Ma, Ana Elena Minatti, Nobuko Nishimura, Alexander J. Pickrell, Hui-Ling Wang, Youngsook Shin, Aaron C. Siegmund, Kevin C. Yang, Nuria A. Tamayo, Mary Walton, Qiufen Xue
  • MACROCYCLIC COMPOUNDS AND METHODS OF USE
    Publication number: 20240294551
    Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S, G13D, Q61H, Q61L or G12C. The compounds have a general Formula I?: wherein the variables of Formula I? are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.
    Type: Application
    Filed: March 25, 2024
    Publication date: September 5, 2024
    Applicant: AMGEN INC.
    Inventors: Ryan Paul Wurz, Yunxiao LI, Primali Vasundera NAVARATNE, Jose M. MEDINA, Ning CHEN, Liping PETTUS, Xiaofen LI, John STELLWAGEN, Kexue LI, Brian Alan LANMAN, Michael M. YAMANO, Wei ZHAO, Benjamin WIGMAN, Fabien EMMETIERE, Albert K. AMEGADZIE, Christopher P. MOHR, Aaron C. SIEGMUND, Rene RAHIMOFF, Zhichen WU, Adriano BAUER, Andrew SMALIGO, Quentin Tercenio, Qingyian Liu, Shon K. Booker