Patents by Inventor Brian Alan MENDELSOHN

Brian Alan MENDELSOHN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR PRODUCING INTERMEDIATE ANTIBODIES REGIOSELECTIVELY MODIFIED, AND ANTIBODY DERIVATIVES REGIOSELECTIVELY HAVING BIOORTHOGONAL FUNCTIONAL GROUP OR FUNCTIONAL SUBSTANCE
    Publication number: 20240218015
    Abstract: A method for producing an intermediate antibody regioselectively modified, which comprises: (1) mixing a solution comprising an antibody material and a solution comprising a reagent for regioselectively modifying an antibody in a micromixer to form a mixture comprising the antibody material and the reagent, wherein the reagent comprises a compound comprising an affinity substance to an antibody and a reactive group to an antibody; and (2) passing the mixture through a reaction channel to allow the antibody material and the reagent to react in the reaction channel to form a solution comprising an intermediate antibody regioselectively modified, wherein the processes (1) and (2) are continuously performed in a flow microreactor, is capable of rapidly producing a desired antibody derivative regioselectively having a functional substance or functional substances.
    Type: Application
    Filed: March 7, 2024
    Publication date: July 4, 2024
    Applicant: Ajinomoto Co., Inc.
    Inventors: Yutaka MATSUDA, Yuichi NAKAHARA, Kei YAMADA, Keisuke KATO, Yuta ENDO, Brian Alan MENDELSOHN
  • DERIVATIVES OF DOLAPROINE-DOLAISOLEUINE PEPTIDES
    Publication number: 20220204557
    Abstract: Provided are peptide analogs, pharmaceutical compositions comprising such compounds, and methods of treating cancer with such compounds.
    Type: Application
    Filed: March 18, 2022
    Publication date: June 30, 2022
    Applicant: AGENSYS, INC.
    Inventors: Brian Alan MENDELSOHN, Julien DUGAL-TESSIER, Stuart Daniel BARNSCHER
  • Derivatives of dolaproine-dolaisoleucine peptides
    Patent number: 11312748
    Abstract: Provided are peptide analogs, pharmaceutical compositions comprising such compounds, and methods of treating cancer with such compounds.
    Type: Grant
    Filed: November 14, 2019
    Date of Patent: April 26, 2022
    Assignee: AGENSYS, INC.
    Inventors: Brian Alan Mendelsohn, Julien Dugal-Tessier, Stuart Daniel Barnscher
  • DERIVATIVES OF DOLAPROINE-DOLAISOLEUINE PEPTIDES
    Publication number: 20200325170
    Abstract: Provided are peptide analogs, pharmaceutical compositions comprising such compounds, and methods of treating cancer with such compounds.
    Type: Application
    Filed: November 14, 2019
    Publication date: October 15, 2020
    Applicant: AGENSYS, INC.
    Inventors: Brian Alan MENDELSOHN, Julien DUGAL-TESSIER, Stuart Daniel BARNSCHER
  • DERIVATIVES OF DOLAPROINE-DOLAISOLEUINE PEPTIDES
    Publication number: 20170190735
    Abstract: Provided are peptide analogs, pharmaceutical compositions comprising such compounds, and methods of treating cancer with such compounds.
    Type: Application
    Filed: May 27, 2015
    Publication date: July 6, 2017
    Applicant: AGENSYS, INC.
    Inventors: Brian Alan MENDELSOHN, Julien DUGAL-TERRIER, Stuart Daniel BARNSCHER
  • AMATOXIN DERIVATIVES AND CELL-PERMEABLE CONJUGATES THEREOF AS INHIBITORS OF RNA POLYMERASE
    Publication number: 20150218220
    Abstract: The present invention relates to analogs of alpha-amanitin, methods of inhibiting RNA polymerase with such compounds, conjugates comprising such compounds, compositions comprising such compounds and conjugates, and methods of treatment using such conjugates.
    Type: Application
    Filed: September 12, 2013
    Publication date: August 6, 2015
    Inventors: Brian Alan Mendelsohn, Sung Ju Moon
  • SUBSTITUTED PEPTIDE ANALOGS
    Publication number: 20130190248
    Abstract: The present invention relates to peptide analogs, antibody-drug conjugates comprising such compounds, pharmaceutical compositions comprising such compounds and conjugates, and methods of treating cancer with such compounds and conjugates.
    Type: Application
    Filed: July 24, 2012
    Publication date: July 25, 2013
    Applicant: AGENSYS, INC.
    Inventors: Brian Alan MENDELSOHN, Stuart Daniel BARNSCHER