Patents by Inventor Brian Albarran

Brian Albarran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for intracellular delivery of biotinylated cargo
    Patent number: 7534819
    Abstract: The invention provides compositions for intracellular delivery of biotinylated cargo. The compositions comprise a complex formed between (a) a fusion protein comprising a protein transduction domain linked to streptavidin and (b) a biotinylated cargo for intracellular delivery. In some embodiments, the protein transduction domain comprises the protein transduction domain of the Human Immunodeficiency Virus type 1 (HIV-1) TAT protein. The complex may further comprise a biotinylated endosomal releasing polymer, such as a poly(propylacrylic acid) polymer. The invention also provides methods for obtaining intracellular delivery of biotinylated cargo and methods for obtaining cytoplasmic delivery of biotinylated cargo.
    Type: Grant
    Filed: June 10, 2005
    Date of Patent: May 19, 2009
    Assignee: University of Washington
    Inventors: Brian Albarran, Patrick S. Stayton, Richard To
  • Compositions and methods for intracellular delivery of biotinylated cargo
    Publication number: 20060281677
    Abstract: The invention provides compositions for intracellular delivery of biotinylated cargo. The compositions comprise a complex formed between (a) a fusion protein comprising a protein transduction domain linked to streptavidin and (b) a biotinylated cargo for intracellular delivery. In some embodiments, the protein transduction domain comprises the protein transduction domain of the Human Immunodeficiency Virus type 1 (HIV-1) TAT protein. The complex may further comprise a biotinylated endosomal releasing polymer, such as a poly(propylacrylic acid) polymer. The invention also provides methods for obtaining intracellular delivery of biotinylated cargo and methods for obtaining cytoplasmic delivery of biotinylated cargo.
    Type: Application
    Filed: June 10, 2005
    Publication date: December 14, 2006
    Applicant: University of Washington
    Inventors: Brian Albarran, Patrick Stayton, Richard To