Abstract: A device for collecting a tissue sample includes a needle extending along a longitudinal axis from a proximal end to a distal end and including a lumen extending therethrough; an opening in a lateral surface of the needle; and a jaw rotatably coupled to the needle for rotation between a closed configuration in which the jaw covers the opening and an open configuration in which the jaw is received within the lumen to expose the opening. The jaw includes a tissue cutting edge which, as the jaw is rotated from the open configuration to the closed configuration, passes out of the opening along a cutting arc to sever any tissue received in the opening from surrounding tissue.

Abstract: A device for collecting a tissue sample includes a needle extending longitudinally from a proximal end to a distal end and including a channel extending therethrough, the distal end including a pair of jaws, at least a first one of the jaws being movable relative to the other between an open configuration, in which the jaws are open to receive tissue therebetween, and a closed configuration in which the jaws are drawn toward one another to collect a tissue sample therein.

Abstract: A device for collecting a tissue sample includes Needle and Stylet. Needle is extending longitudinally from a proximal to a distal end and includes a lumen extending therethrough. Stylet is movably housed in the lumen and extending along a longitudinal axis from a proximal to a distal end and includes a scooper at the distal end thereof. The scooper is connected to a proximal portion of Stylet via a hinge biased toward a bent position in which the scooper is bent away from the longitudinal axis. Stylet is movable between a constrained configuration and a tissue-collecting configuration. The scooper includes a channel extending longitudinally therethrough and a window extending laterally through a wall thereof in communication with the channel to collect a tissue sample therethrough as Stylet is moved from the tissue-collecting to the constrained.

Abstract: The invention is directed to a device and method to prevent migration of Human Mesenchymal Stem Cells (hMSCs) from a delivery site while allowing communication between the stem cells and native cardiomyocytes. The device is characterized by scaffold pore size, fiber diameter and biomaterial selection. The invention includes a two part polyurethane scaffold that prevents migration of stem cells, allows gap junction formation through pores and is packaged for minimally invasive delivery.

Abstract: The invention is directed to a device and method to prevent migration of Human Mesenchymal Stem Cells (hMSCs) from a delivery site while allowing communication between the stem cells and native cardiomyocytes. The device is characterized by scaffold pore size, fiber diameter and biomaterial selection. The invention includes a two part polyurethane scaffold that prevents migration of stem cells, allows gap junction formation through pores and is packaged for minimally invasive delivery.