Abstract: The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of CDK enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with CDK signaling with the compounds and compositions of the disclosure.

Abstract: A computer input system includes a mouse including a housing having an interior surface defining an internal volume and a sensor assembly disposed in the internal volume. A processor is electrically coupled to the sensor assembly and a memory component having electronic instructions stored thereon that, when executed by the processor, causes the processor to determine an orientation of the mouse relative to a hand based on a touch input from the hand detected by the sensor assembly. The mouse can also have a circular array of touch sensors or lights that detect hand position and provide orientation information to the user.

Abstract: A beam director subsystem and method for use in a weapons system. The beam director subsystem includes a source of electromagnetic radiation for generating a high energy laser (HEL) beam. The electromagnetic radiation is directed to a secondary mirror that reflects the electromagnetic radiation to a primary mirror for output of the HEL beam. The secondary mirror is generally curved and expands the electromagnetic radiation received from the source prior to outputting the HEL beam from the primary mirror. The subsystem further includes a track telescope coupled to the housing. The track telescope has a track detector configured to receive electromagnetic radiation originating from the HEL and electromagnetic radiation emitted from an illuminator and reflected from an airborne target.

Abstract: An ozone generator is provided wherein pressure controlled air is supplied to an enclosure containing an ultraviolet light source arranged so that the air circulates cylonically about the source to exit the enclosure. Temperature control for lamp and air in the housing is provided.