Abstract: Antibody molecules that specifically bind to C5aR1 are disclosed. The antibody molecules can be used to treat, prevent, and/or diagnose disorders, such as ANCA-vasculitis.

Abstract: The present disclosure provides, among other things, two different formats of humanized antibodies against human complement component 5a receptor I. The disclosure also provides a method of treating a subject having dysfunctions of C5a/C5aR1 axis pathway, including but not limited to ANCA-associated vasculitis, comprising administering to the subject in need thereof a an effective amount of antibody or a nucleic encoding an antibodies binding to C5aR1 described herein, and wherein administering results in a decrease in symptoms associated with C5a/C5aR1 associated dysfunction in the subject.

Abstract: A moisture-retentive fabric medium includes a hydrophilic, thermoplastic polyester fiber as a blend of from 10-905% or 20-80% by total weight of textile fibers and 90-10% or 80-20% by total weight of hydrophilic textile fibers and less than 0.5% by weight of total fabric medium as microfibrillated cellulose fiber and less than 0.05% by weight superabsorbent polymers, the polyester having a melting point between 190-500 F when measured in accordance with ASTM D-3418.

Abstract: Systems and methods for interest-driven business intelligence systems in accordance with embodiments of the invention are illustrated. In one embodiment, an interest-driven distributed data server system includes a processor, an interest-driven distributed data server application, aggregate data storage, and a data source directory, wherein the interest-driven distributed data server application configures the processor to obtain reporting data requirements, determine at least one data dimension using the reporting data requirements, identify at least one data source identified that can provide data associated with the data dimension, generate data source job data, transmit the data source job data to at least one data source, and receive job response data, store the received job response data in the aggregate data storage, build reporting data based on the reporting data requirements, and transmit the reporting data.

Abstract: Systems and methods for interest-driven business intelligence systems including event-oriented data in accordance with embodiments of the invention are illustrated. In one embodiment, an interest-driven business intelligence system includes raw data storage configured to contain raw data and perform ETL processes, a data mart configured to contain metadata that describes the raw data, and an intermediate processing layer, wherein the intermediate processing layer is configured to compile an interest-driven data pipeline configured to generate ETL processing jobs to generate event-oriented data from the raw data by filtering the raw data based on the metadata describing the raw data, determining ordering data based on the metadata describing the raw data, aligning the filtered raw data based on the ordering data, and generating event-oriented data based on the aligned filtered raw data, and storing the event-oriented data in the data mart.

Abstract: Systems and methods for interest-driven data sharing in interest-driven business intelligence systems in accordance with embodiments of the invention are illustrated.

Abstract: Systems and methods for interest-driven business intelligence systems in accordance with embodiments of the invention are illustrated. In one embodiment, an interest-driven distributed data server system includes a processor, an interest-driven distributed data server application, aggregate data storage, and a data source directory, wherein the interest-driven distributed data server application configures the processor to obtain reporting data requirements, determine at least one data dimension using the reporting data requirements, identify at least one data source identified that can provide data associated with the data dimension, generate data source job data, transmit the data source job data to at least one data source, and receive job response data, store the received job response data in the aggregate data storage, build reporting data based on the reporting data requirements, and transmit the reporting data.

Abstract: Interest-driven business intelligence server systems that provide performance metadata are described. In the disclosed embodiments, an interest-driven business intelligence server system receives a report specification. The report specification includes at least reporting data requirement. The interest-driven business intelligence server determines performance metadata information for an interest-driven data pipeline that is utilized to generate reporting data based on the report specification. The performance metadata information for the interest-driven data pipeline is transmitted to an interest-driven user visualization system by the interest-driven business intelligence server system.

Abstract: Interest-driven business intelligence server systems that provide performance metadata are described. In the disclosed embodiments, an interest-driven business intelligence server system receives a report specification. The report specification includes at least reporting data requirement. The interest-driven business intelligence server determines performance metadata information for an interest-driven data pipeline that is utilized to generate reporting data based on the report specification. The performance metadata information for the interest-driven data pipeline is transmitted to an interest-driven user visualization system by the interest-driven business intelligence server system.

Abstract: Systems and methods for interest-driven business intelligence systems in accordance with embodiments of the invention are illustrated. In one embodiment, an interest-driven distributed data server system includes a processor, an interest-driven distributed data server application, aggregate data storage, and a data source directory, wherein the interest-driven distributed data server application configures the processor to obtain reporting data requirements, determine at least one data dimension using the reporting data requirements, identify at least one data source identified that can provide data associated with the data dimension, generate data source job data, transmit the data source job data to at least one data source, and receive job response data, store the received job response data in the aggregate data storage, build reporting data based on the reporting data requirements, and transmit the reporting data.

Abstract: Systems and methods for interest-driven business intelligence systems including event-oriented data in accordance with embodiments of the invention are illustrated. In one embodiment, an interest-driven business intelligence system includes raw data storage configured to contain raw data and perform ETL processes, a data mart configured to contain metadata that describes the raw data, and an intermediate processing layer, wherein the intermediate processing layer is configured to compile an interest-driven data pipeline configured to generate ETL processing jobs to generate event-oriented data from the raw data by filtering the raw data based on the metadata describing the raw data, determining ordering data based on the metadata describing the raw data, aligning the filtered raw data based on the ordering data, and generating event-oriented data based on the aligned filtered raw data, and storing the event-oriented data in the data mart.

Abstract: Systems and methods for interest-driven business intelligence systems including segment data in accordance with embodiments of the invention are illustrated. In one embodiment, an interest-driven data visualization system includes a processor and a memory wherein an interest-driven data visualization application configures the processor to define reporting data requirements, including at least one piece of reporting data metadata, generate data retrieval job data, transmit the data retrieval job data to an interest-driven business intelligence server system, receive source data from the interest-driven business intelligence server system, create at least one piece of reporting data using the received source data, the data description metadata, and the reporting data metadata, and generate a set of segment data based on the reporting data, where a piece of segment data in the set of segment data includes a subset of the reporting data.

Abstract: A filter and filter media configured and arranged for placement in a fuel stream is disclosed. The filter and filter media allow for filtering of liquid fuels, such as diesel fuel. In certain embodiments the filter media includes a media fiber, such as melt blown polyester; and a scaffold fiber, also such as such as melt blown polyester, having a larger diameter than the media fiber. The media and scaffold fibers combine to create a media structure having low solidity and relatively low compressibility, and which contain a pore structure that avoids premature fouling of the filter by fuel degradation products.

Abstract: Systems and methods for interest-driven business intelligence systems in accordance with embodiments of the invention are illustrated. In one embodiment, an interest-driven distributed data server system includes a processor, an interest-driven distributed data server application, aggregate data storage, and a data source directory, wherein the interest-driven distributed data server application configures the processor to obtain reporting data requirements, determine at least one data dimension using the reporting data requirements, identify at least one data source identified that can provide data associated with the data dimension, generate data source job data, transmit the data source job data to at least one data source, and receive job response data, store the received job response data in the aggregate data storage, build reporting data based on the reporting data requirements, and transmit the reporting data.

Abstract: Interest-driven business intelligence server systems that provide performance metadata are described. In the disclosed embodiments, an interest-driven business intelligence server system receives a report specification. The report specification includes at least reporting data requirement. The interest-driven business intelligence server determines performance metadata information for an interest-driven data pipeline that is utilized to generate reporting data based on the report specification. The performance metadata information for the interest-driven data pipeline is transmitted to an interest-driven user visualization system by the interest-driven business intelligence server system.

Abstract: Systems and methods for interest-driven data sharing in interest-driven business intelligence systems in accordance with embodiments of the invention are illustrated.

Abstract: The web of the invention can comprise a super absorbent layer that can act as an moisture sensitive fuel shut-off valve, absorbent, adsorbant or reactant. The web of the invention can comprise a super absorbent fabric or layer made of a superabsorbent particle or fiber. Fluid, gas or liquid, that flows through or by the assemblies of the invention can have any gas, liquid or solid material dispersed or dissolved in the fluid interact with the super absorbent particulate. The structures of the invention can act simply as flow-by reactive, absorptive, or adsorptive layers with no filtration properties, or the structures of the invention can be assembled into filters.

Abstract: The web of the invention can comprise a super absorbent layer that can act as an moisture sensitive fuel shut-off valve, absorbent, adsorbant or reactant. The web of the invention can comprise a super absorbent fabric or layer made of a superabsorbent particle or fiber. Fluid, gas or liquid, that flows through or by the assemblies of the invention can have any gas, liquid or solid material dispersed or dissolved in the fluid interact with the super absorbent particulate. The structures of the invention can act simply as flow-by reactive, absorptive, or adsorptive layers with no filtration properties, or the structures of the invention can be assembled into filters.

Abstract: The web of the invention can comprise a super absorbent layer that can act as an moisture sensitive fuel shut-off valve, absorbent, adsorbant or reactant. The web of the invention can comprise a super absorbent fabric or layer made of a superabsorbent particle or fiber. The web can comprise a nanofiber layer having dispersed within the nanofiber layer a super absorbent particulate and optionally a second particulate material that can act as an absorbent, adsorbant or reactant. Fluid, gas or liquid, that flows through or by the assemblies of the invention can have any gas, liquid or solid material dispersed or dissolved in the fluid interact with the super absorbent particulate. If needed these materials can also react with, be absorbed by, or adsorbed onto, the active particulate within the nanofiber layer.

Abstract: The web of the invention can comprise a super absorbent layer that can act as an moisture sensitive fuel shut-off valve, absorbent, adsorbent or reactant. The web of the invention can comprise a super absorbent fabric or layer made of a superabsorbent particle or fiber. The web can comprise a nanofiber layer having dispersed within the nanofiber layer a super absorbent particulate and optionally a second particulate material that can act as an absorbent, adsorbent or reactant. Fluid, gas or liquid, that flows through or by the assemblies of the invention can have any gas, liquid or solid material dispersed or dissolved in the fluid interact with the super absorbent particulate. If needed these materials can also react with, be absorbed by, or adsorbed onto, the active particulate within the nanofiber layer.