Patents by Inventor Brian Bacskai

Brian Bacskai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Development and screening of contrast agents for in vivo imaging of Parkinson's disease
    Patent number: 9242015
    Abstract: The invention provides compounds and a method for imaging aggregated ?-synuclein, e.g., Lewy bodies or Lewy neurites, in a tissue or organ.
    Type: Grant
    Filed: November 11, 2011
    Date of Patent: January 26, 2016
    Assignee: The General Hospital Corporation
    Inventor: Brian Bacskai
  • DEVELOPMENT AND SCREENING OF CONTRAST AGENTS FOR IN VIVO IMAGING OF PARKINSON'S DISEASE
    Publication number: 20130259805
    Abstract: The invention provides compounds and a method for imaging aggregated ?-synuclein, e.g., Lewy bodies or Lewy neurites, in a tissue or organ.
    Type: Application
    Filed: November 11, 2011
    Publication date: October 3, 2013
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventor: Brian Bacskai
  • In vivo multiphoton diagnostic detection and imaging of a neurodegenerative disease
    Patent number: 7668586
    Abstract: The present invention is directed to a method of detecting a neurodegenerative disease in a mammal by activating brain tissue of the mammal by application of radiation under conditions effective to promote a simultaneous multiphoton excitation of the brain tissue and to emit a fluorescence characteristic. The fluorescence characteristic is then compared to a standard fluorescence emitted by exciting healthy brain tissue of the mammal under the same conditions used to carry out the activating step. Brain tissue where the fluorescence characteristic differs from the standard fluorescence is identified as potentially having a neurodegenerative disease. Another aspect of the present invention is directed to a method of producing an image of brain tissue from a mammal by activating brain tissue of a mammal with radiation applied under conditions effective to promote a simultaneous multiphoton excitation of the brain tissue and to produce fluorescence.
    Type: Grant
    Filed: October 31, 2001
    Date of Patent: February 23, 2010
    Assignees: Cornell Research Foundation, Inc., The General Hospital Corporation
    Inventors: Bradley T. Hyman, Richard Christie, Brian Bacskai, Watt W. Webb, Warren R. Zipfel
  • Heterocyclic Dye Compounds For In Vivo Imaging And Diagnosis Of Alzheimer's Disease
    Publication number: 20090087376
    Abstract: The present invention relates to the identification of compounds that are suitable for imaging amyloid deposits in living patients. The invention relates, in part, to a method of imaging amyloid deposits in brain in vivo to allow antemortem diagnosis of Alzheimer's disease. The present invention also relates to therapeutic uses for such compounds, as exemplified by compounds of the formula (1) in which Y is independently S, O, or N and m is 1, 2, or 3.
    Type: Application
    Filed: July 15, 2005
    Publication date: April 2, 2009
    Applicants: The General Hospital Corporation, Massachusetts Institute of Technology, University of Pittsburg of the Commonwealth System of Higher Education
    Inventors: Brian Bacskai, Bradley T. Hyman, William E. Klunk, Chester A. Mathis, Timothy Swager, Evgueni Nesterov, Ivory Hills
  • Methods to monitor molecule conformation and molecule/molecule proximity
    Publication number: 20050048539
    Abstract: The invention relates in part to methods for monitoring the conformation of molecules, include proteins. The methods of the invention are also useful to monitor the distance between two or more molecules, such as the distance between two proteins in a cell. Additionally, the methods of the invention are useful for determining the location of a molecule, e.g. a protein, within a cell or other environment. The invention also relates in part to assays for identifying and testing candidate compounds for modulating molecule conformation and/or molecule interactions.
    Type: Application
    Filed: June 14, 2004
    Publication date: March 3, 2005
    Applicant: The General Hospital Corporation
    Inventors: Bradley Hyman, Oksana Berezovska, Brian Bacskai, Alberto Lleo
  • In vivo multiphoton diagnostic detection and imaging of a neurodegenerative disease
    Publication number: 20030009104
    Abstract: The present invention is directed to a method of detecting a neurodegenerative disease in a mammal by activating brain tissue of the mammal by application of radiation under conditions effective to promote a simultaneous multiphoton excitation of the brain tissue and to emit a fluorescence characteristic. The fluorescence characteristic is then compared to a standard fluorescence emitted by exciting healthy brain tissue of the mammal under the same conditions used to carry out the activating step. Brain tissue where the fluorescence characteristic differs from the standard fluorescence is identified as potentially having a neurodegenerative disease. Another aspect of the present invention is directed to a method of producing an image of brain tissue from a mammal by activating brain tissue of a mammal with radiation applied under conditions effective to promote a simultaneous multiphoton excitation of the brain tissue and to produce fluorescence.
    Type: Application
    Filed: October 31, 2001
    Publication date: January 9, 2003
    Inventors: Bradley T. Hyman, Richard Christie, Brian Bacskai, Watt W. Webb, Warren R. Zipfel