Abstract: An apparatus is disclosed as including a first material volume with at least a hardened portion and a second material volume that includes at least two layers. The first material volume is composed of at least a hardenable alloy of steel. The at least two layers is located adjacent to a first surface comprising the hardened portion of the first material volume. The at least two layers includes a first layer composed of at least a ductile low-carbon alloy of steel and a second layer composed of at least a cobalt-based hardfacing over the first layer. The apparatus is applicable in preparing shear ram blocks and shear ram blades to provide a hardened blade edge with an adjacent hardfacing surface.

Abstract: An apparatus is disclosed as including a first material volume with at least a hardened portion and a second material volume that includes at least two layers. The first material volume is composed of at least a hardenable alloy of steel. The at least two layers is located adjacent to a first surface comprising the hardened portion of the first material volume. The at least two layers includes a first layer composed of at least a ductile low-carbon alloy of steel and a second layer composed of at least a cobalt-based hardfacing over the first layer. The apparatus is applicable in preparing shear ram blocks and shear ram blades to provide a hardened blade edge with an adjacent hardfacing surface.

Abstract: The present disclosure provides methods for the prevention or treatment of metabolic disorders. In exemplary embodiments, methods of administering an anti-CGRP antibody are provided, optionally in combination with a second agent, wherein peripheral and/or hepatic glucose utilization is increased, thereby preventing or treating diseases and disorders associated with insulin resistance. Compositions comprising an anti-CGRP antibody are also provided, optionally in combination with a second agent, which are suitable for administration to increase peripheral and/or hepatic glucose utilization and thereby prevent or treat diseases and disorders associated with insulin resistance.

Abstract: Creating an effective system and/or method for providing right-sized in-home care requires solving a unique logistics problem: how to optimize a fleet of disparate mobile care resources to geographically distributed and disparate patients, each with an individualized healthcare need. The integrated mobile care unit dispatching tool disclosed herein may schedule and proactively re-schedule in-home care using mobile care units. The mobile care unit dispatching tool accounts for an array of disparate mobile care resources (e.g., different specializations, or a lack of any specialization) and disparate patient needs, any or all of which may change over time, to create and maximize the value of patient schedules for treatment.

Abstract: A method, apparatus, and system are directed towards providing advertisement insertions at a point of consumption into digital content, such as broadcast television content. A content provider may initially mark the content for advertisement insertion, and create a metadata file indicating constraints, targets, expirations, or the like. A downstream user employs a plug-in component and provides an initial user profile, in part, to access the content with advertisements. As the content is played, and an advertising marker is encountered, fast forwarding or other skipping features are disabled, and an advertisement stream is spliced into the content stream. The advertisement stream is determined based on the user profile and/or other metadata. Moreover, the advertisement stream may be obtained over a network such that advertisements may be refreshed even years after the content has been acquired by the user. In one embodiment, the advertisement consumption may be tracked and reported.

Abstract: The techniques of this disclosure relate to determining an optical characteristic of a camera. The device includes a housing that receives a test fixture retaining a camera. The housing includes a first segment and a second segment creating a chamber surrounding the camera. The first segment is attached to the test fixture and defines a first orifice located in a side of the first segment. The first orifice directs a flow of a gas out of the chamber. The second segment defines a second orifice located in a first side of the second segment to direct the flow of the gas into the chamber. An aperture is located in a second side of the second segment and positioned opposite the test fixture to define a field of view that includes a camera target. The aperture receives a lens barrel of the camera and enables the determination of the optical characteristic.

Abstract: The techniques of this disclosure relate to determining an optical characteristic of a camera. The device includes a housing that receives a test fixture retaining a camera. The housing includes a first segment and a second segment creating a chamber surrounding the camera. The first segment is attached to the test fixture and defines a first orifice located in a side of the first segment. The first orifice directs a flow of a gas out of the chamber. The second segment defines a second orifice located in a first side of the second segment to direct the flow of the gas into the chamber. An aperture is located in a second side of the second segment and positioned opposite the test fixture to define a field of view that includes a camera target. The aperture receives a lens barrel of the camera and enables the determination of the optical characteristic.

Abstract: The present invention relates to a novel crosswalk light device. The device is designed to ensure that a crosswalk is highly visible during nighttime and other lowlight hours of the day to prevent accidents. The device comprises an LED floodlight mounted on top of a pedestrian crosswalk signal. The light illuminates the crosswalk area during the walking phase of the crosswalk. The light is wired through a series of relays and a capacitor to hold steady voltage. Accordingly, the device maintains an optimal level of safety for both pedestrians and motorists.

Abstract: The techniques of this disclosure relate to determining an optical characteristic of a camera. The device includes a housing that receives a test fixture retaining a camera. The housing includes a first segment and a second segment creating a chamber surrounding the camera. The first segment is attached to the test fixture and defines a first orifice located in a side of the first segment. The first orifice directs a flow of a gas out of the chamber. The second segment defines a second orifice located in a first side of the second segment to direct the flow of the gas into the chamber. An aperture is located in a second side of the second segment and positioned opposite the test fixture to define a field of view that includes a camera target. The aperture receives a lens barrel of the camera and enables the determination of the optical characteristic.

Abstract: An apparatus is disclosed as including a first material volume with at least a hardened portion and a second material volume that includes at least two layers. The first material volume is composed of at least a hardenable alloy of steel. The at least two layers is located adjacent to a first surface comprising the hardened portion of the first material volume. The at least two layers includes a first layer composed of at least a ductile low-carbon alloy of steel and a second layer composed of at least a cobalt-based hardfacing over the first layer. The apparatus is applicable in preparing shear ram blocks and shear ram blades to provide a hardened blade edge with an adjacent hardfacing surface.

Abstract: An apparatus is disclosed as including a first material volume with at least a hardened portion and a second material volume that includes at least two layers. The first material volume is composed of at least a hardenable alloy of steel. The at least two layers is located adjacent to a first surface comprising the hardened portion of the first material volume. The at least two layers includes a first layer composed of at least a ductile low-carbon alloy of steel and a second layer composed of at least a cobalt-based hardfacing over the first layer. The apparatus is applicable in preparing shear ram blocks and shear ram blades to provide a hardened blade edge with an adjacent hardfacing surface.

Abstract: A reduced calorie filling composition may include a chocolate component and an aqueous component. The chocolate component may be present in an amount from about 30% to about 70% by weight of the reduced calorie filling composition. The aqueous component may include water in an amount from about 9% to about 20% by weight of the reduced calorie filling composition. In addition, the aqueous component may include a sweetener component in an amount from about 5% to about 30% by weight of the reduced calorie filling composition. The aqueous component may also includes a humectant in an amount from about 2% to about 10% by weight of the reduced calorie filling composition. A confectionery product may be a finished reduced calorie confectionery product having a reduced calorie coating composition on the reduced calorie filling composition. The finished reduced calorie confectionery product may be a reduced calorie truffle.

Abstract: Disclosed herein are methods for predicting immunogenicity of a candidate peptide. The method comprises obtaining a three-dimensional candidate structural representation of the candidate peptide bound to an antigen presenting molecule; obtaining a plurality of candidate measurements; and predicting, with an electronic processor, the immunogenicity of the candidate peptide based upon the plurality of candidate measurements. Further disclosed herein are methods for producing vaccines. The method for producing a vaccine comprises predicting immunogenicity of one or more candidate peptides using the methods described herein, and producing a vaccine comprising one or more peptides predicted to be immunogenic.

Abstract: Described are methods for predicting affinity of a candidate molecule for a second molecule. The method comprises obtaining a three-dimensional candidate structural representation of the candidate molecule bound to a second molecule; obtaining a plurality of candidate measurements, wherein each candidate measurement is associated with at least one feature of the candidate structural representation; and predicting, with an electronic processor, the affinity of the candidate molecule for the second molecule, wherein the electronic processor is configured to predict the affinity of the candidate molecule for the second molecule based upon the plurality of candidate measurements. The candidate molecule may be a peptide, such as a neoantigen, a viral peptide, a non-mutated self peptide, or a post-translationally modified peptide. The second molecule may be an antigen presenting molecule, such as a class I MHC molecule or a class II MHC molecule.

Abstract: A membrane based microelectronic device (200) can include a printed circuit board (202), a polymer film (210) laminated onto the circuit board, and one or more microelectromechanical components (208) integrated into the printed circuit board (202). At least a portion of the polymer film (210) forms a membrane element of the one or more microelectromechanical components (208).

Abstract: A method, apparatus, and system are directed towards providing advertisement insertions at a point of consumption into digital content, such as broadcast television content. A content provider may initially mark the content for advertisement insertion, and create a metadata file indicating constraints, targets, expirations, or the like. A downstream user employs a plug-in component and provides an initial user profile, in part, to access the content with advertisements. As the content is played, and an advertising marker is encountered, fast forwarding or other skipping features are disabled, and an advertisement stream is spliced into the content stream. The advertisement stream is determined based on the user profile and/or other metadata. Moreover, the advertisement stream may be obtained over a network such that advertisements may be refreshed even years after the content has been acquired by the user. In one embodiment, the advertisement consumption may be tracked and reported.

Abstract: An apparatus is disclosed as including a first material volume with at least a hardened portion and a second material volume that includes at least two layers. The first material volume is composed of at least a hardenable alloy of steel. The at least two layers is located adjacent to a first surface comprising the hardened portion of the first material volume. The at least two layers includes a first layer composed of at least a ductile low-carbon alloy of steel and a second layer composed of at least a cobalt-based hardfacing over the first layer. The apparatus is applicable in preparing shear ram blocks and shear ram blades to provide a hardened blade edge with an adjacent hardfacing surface.

Abstract: The present disclosure provides methods for the prevention or treatment of metabolic disorders. In exemplary embodiments, methods of administering an anti-CGRP antibody are provided, optionally in combination with a second agent, wherein peripheral and/or hepatic glucose utilization is increased, thereby preventing or treating diseases and disorders associated with insulin resistance. Compositions comprising an anti-CGRP antibody are also provided, optionally in combination with a second agent, which are suitable for administration to increase peripheral and/or hepatic glucose utilization and thereby prevent or treat diseases and disorders associated with insulin resistance.

Abstract: Molecular constructs and dual recognition constructs having a sequence encoding a TCR affinity weakening motif, and DNA and RNA sequences corresponding thereto, are presented. Modified T-cells and other cells transformed with the molecular contracts express a modified TCR that imparts a reduction, in non-specific binding, -an enhancement of binding specificity and an enhancement of binding affinity for a target antigen, compared to non-transformed (wild-type, native) T-cells, are described. The modified TCRs possess an affinity enhancing motif and an affinity weakening motif. Methods of transforming cells and methods of using enriched populations of transformed cells, in the treatment of cancer and infections arid T-cell mediated pathologies are provided. The affinity weakening motif imparts a weakened interaction, of a TCR with major histocompatibility complex proteins, such as HLA proteins in humans.

Abstract: An apparatus is disclosed as including a first material volume with at least a hardened portion and a second material volume that includes at least two layers. The first material volume is composed of at least a hardenable alloy of steel. The at least two layers is located adjacent to a first surface comprising the hardened portion of the first material volume. The at least two layers includes a first layer composed of at least a ductile low-carbon alloy of steel and a second layer composed of at least a cobalt-based hardfacing over the first layer. The apparatus is applicable in preparing shear ram blocks and shear ram blades to provide a hardened blade edge with an adjacent hardfacing surface.