Abstract: Described herein in aspects is a humanized anti-class II MHC antibody, wherein the humanized antibody binds to class II MHC with similar or increased affinity and/or specificity as compared with a non-humanized anti-MHC class II antibody that specifically binds to a shared epitope on most or all HLA-DR molecules. Related methods and uses are also described.

Abstract: A precursor composition comprising, before cure, an acrylic ethylene monomer (AEM), a foaming agent, and one or more of a strengthening additive, a thermal ablation additive, or a reflectivity additive. The precursor composition is cured to form a protective article comprising a foamed protective material. A method of forming a protective article is also disclosed, as is an aerospace structure comprising the foamed protective material.

Abstract: Described herein is an anti-class II MHC antibody fused to a SARS-CoV-2 antigen. Also described is a vaccine comprising the antibody and methods for treating and/or preventing SARS-CoV-2, wherein the methods comprise administering the antibody to a subject in need thereof. In typical aspects, the vaccine is free of an adjuvant.

Abstract: A protective assembly comprises a first region formulated and configured to provide protection from alpha, beta, and electromagnetic radiation and comprising a composite of particles and polymer; a second region formulated and configured to provide protection from ballistic impact and comprising a composite of fibers and polymer; and a third region formulated and configured to provide protection from thermal radiation and comprising a composite of particles, fiber, and polymer. The protective assembly may be provided on an aerospace structure. The protective assembly may be formed on the aerospace structure body using a co-curing process.

Abstract: A protective cap for fluidly sealing a connector of a cable is provided. The protective cap includes a flexible body having an interior cavity with a distal opening through which the connector is inserted. The distal opening is defined by an annular ridge that engages a cable portion proximal the connector to fluidly seal the entire connector within the cavity. The body portion may have an oval-shaped cross-section while the interior cavity is cylindrical so that the portions wider portions of the body provide longitudinal rigidity to facilitate installation and removal of the cap by a manual pushing and pulling. A tether may be included to attach the cap to a distal portion of the cable. The protective cap and tether may be integrally formed of a soft, highly flexible material to improve ease of use, biocompatibility and patient comfort.

Abstract: An improved method of inducing and/or enhancing an immune response to a tumor antigen is disclosed. The method involves administering the tumor antigen, nucleic acid coding therefor, vectors and/or cells comprising said nucleic acid, or vaccines comprising the aforementioned to a lymphatic site.

Abstract: A protective cap for fluidly sealing a connector of a cable is provided. The protective cap includes a flexible body having an interior cavity with a distal opening through which the connector is inserted. The distal opening is defined by an annular ridge that engages a cable portion proximal the connector to fluidly seal the entire connector within the cavity. The body portion may have an oval-shaped cross-section while the interior cavity is cylindrical so that the portions wider portions of the body provide longitudinal rigidity to facilitate installation and removal of the cap by a manual pushing and pulling. A tether may be included to attach the cap to a distal portion of the cable. The protective cap and tether may be integrally formed of a soft, highly flexible material to improve ease of use, biocompatibility and patient comfort.

Abstract: An improved method of inducing and/or enhancing an immune response to a tumor antigen is disclosed. The method involves administering the tumor antigen. nucleic acid coding therefor, vectors and/or cells comprising said nucleic acid or vaccines comprising the aforementioned to a lymphatic site.

Abstract: An improved method of inducing and/or enhancing an immune response to a tumor antigen is disclosed. The method involves administering the tumor antigen, nucleic acid coding therefor, vectors and/or cells comprising said nucleic acid, or vaccines comprising the aforementioned to a lymphatic site.

Abstract: An improved method of inducing and/or enhancing an immune response to a tumor antigen is disclosed. The method involves administering the tumor antigen, nucleic acid coding therefor, vectors and/or cells comprising said nucleic acid, or vaccines comprising the aforementioned to a lymphatic site.

Abstract: A surgical instrument and a method according to which a vane is disposed in a rotor housing and is rotated by the impingement of air on the vane to drive a shaft to which a surgical tool is attached. The housing is fabricated of a relatively hard material to reduce the wear on it when compared to other materials.

Abstract: A surgical instrument and method according to which at least a portion of a collet housing is inserted into a motor case. A locking element locks the collet housing to the motor case and includes a circumferentially-extending channel formed therein and into which a distal portion of the motor case extends.

Abstract: Hybrid antigens comprising at least one antigenic domain, at least one heat shock protein binding domain, and at least one improved peptide linker there between are described which are useful for the induction of an immune response to the antigenic domain when administered alone or in a complex with at least one heat shock protein. The hybrid antigens and complexes can be used to treat infectious diseases and cancers that express an antigen of the antigenic domain.

Abstract: Hybrid antigens comprising an antigenic domain and improved heat shock protein binding domains are described which are useful for the induction of an immune response to the antigenic domain and thus can be used to treat infectious diseases and cancers that express an antigen of the antigenic domain.

Abstract: An apparatus and method are provided for applying adhesive to an outer circumference of a section of tubing. The apparatus includes opposed grippers with concave adhesive transfer areas that can be moved into surrounding relationship with the tubing. Adhesive dispensing passages communicate with the adhesive transfer areas for delivering adhesive to the tubing. Counterbores are at opposed ends of the adhesive transfer areas and communicate with a vacuum source for removing excess adhesive.

Abstract: An apparatus and method are provided for applying adhesive to an outer circumference of a section of tubing. The apparatus includes opposed grippers with concave adhesive transfer areas that can be moved into surrounding relationship with the tubing. Adhesive dispensing passages communicate with the adhesive transfer areas for delivering adhesive to the tubing. Counterbores are at opposed ends of the adhesive transfer areas and communicate with a vacuum source for removing excess adhesive.

Abstract: The present invention provides reagents and methods for producing and utilizing targeted immunogens. In preferred embodiments, an immunogen is conjugated to an amino acid sequence that targets the immunogen to the MHC presentation pathway. Using the reagents and methods provided herein, immunization protocols may be enhanced resulting in increased immunity of the host.