Patents by Inventor Brian Bierie

Brian Bierie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for targeting cancer stem cells
    Patent number: 10398672
    Abstract: Aspects of the disclosure relate to methods that involve activating the Protein Kinase A (PKA) pathway to induce cancer stem cells (CSCs) to undergo a mesenchymal to epithelial transition. Methods provided herein are useful, in some embodiments, because they render CSCs amenable to treatment with conventional cancer therapies. In some embodiments, methods are provided that involve assaying PKA pathway activity to identify compounds that selectively target CSCs.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: September 3, 2019
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Diwakar Pattabiraman, Brian Bierie, Wai Leong Tam, Robert A. Weinberg
  • METHODS AND COMPOSITIONS FOR TARGETING CANCER STEM CELLS
    Publication number: 20170049745
    Abstract: Aspects of the disclosure relate to methods that involve activating the Protein Kinase A (PKA) pathway to induce cancer stem cells (CSCs) to undergo a mesenchymal to epithelial transition. Methods provided herein are useful, in some embodiments, because they render CSCs amenable to treatment with conventional cancer therapies. In some embodiments, methods are provided that involve assaying PKA pathway activity to identify compounds that selectively target CSCs.
    Type: Application
    Filed: April 29, 2015
    Publication date: February 23, 2017
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: Diwakar Pattabiraman, Brian Bierie, Wai Leong Tam, Robert A. Weinberg