Abstract: The present disclosure provides, among other things, two different formats of humanized antibodies against human complement component 5a receptor I. The disclosure also provides a method of treating a subject having dysfunctions of C5a/C5aR1 axis pathway, including but not limited to ANCA-associated vasculitis, comprising administering to the subject in need thereof an effective amount of antibody or a nucleic encoding an antibodies binding to C5aR1 described herein, and wherein administering results in a decrease in symptoms associated with C5a/C5aR1 associated dysfunction in the subject.

Abstract: Systems and methods are provided, which relate to identification, troubleshooting, and maintenance/repair of water systems and water devices within such systems. A given water device may include an identifier which may be captured by an installation device when attempting to install the water device and sent to a remote server. The remote server may identify the water device and provide installation support, registration, and/or configuration of the water device. Configuration of the water device may be performed based on configurations of other highly-performing water devices that are similar to the water device, as identified by the server. Problem signatures associated with known possible problems that may arise within a water device may be generated and stored in memory, then may be referenced against real-time device operation data and/or configuration data of the water device in order to diagnose and recommend remediation of problems with the water device.

Abstract: Disclosed herein are engineered latent guide RNAs targeting LRRK2 and compositions comprising the same for treatment of diseases or conditions (e.g. Parkinson's Disease) in a subject. Also disclosed herein are methods of treating diseases or conditions (e.g. Parkinson's Disease) in a subject by administering engineered latent guide RNAs or pharmaceutical compositions described herein.

Abstract: The present disclosure provides, among other things, two different formats of humanized antibodies against human complement component 5a receptor I. The disclosure also provides a method of treating a subject having dysfunctions of C5a/C5aR1 axis pathway, including but not limited to ANCA-associated vasculitis, comprising administering to the subject in need thereof an effective amount of antibody or a nucleic encoding an antibodies binding to C5aR1 described herein, and wherein administering results in a decrease in symptoms associated with C5a/C5aR1 associated dysfunction in the subject.

Abstract: Systems for monitoring a sump pump are provided. A system includes a power adapter designed to receive power from a power source. The power adapter is provided in the form of a controller establishing a wireless connection a wireless network and a housing having a first receptacle and a second receptacle. The first receptacle and the second receptacle are designed to accept a float-switch input and a sump pump input, respectively. The float-switch input and the sump pump input are electrically coupled to controller and the power source when accepted by the first receptacle and the second receptacle, respectively.

Abstract: Systems and methods for generating a polymer sequence for a biological molecule having one or more target biological properties are provided. A plurality of target metric values for one or more target biological properties of a biological molecule and a seed for a nucleic acid or amino acid sequence for the biological molecule are inputted into a conditional generator model of a conditional generative adversarial network to obtain as output from the conditional generator model a nucleic acid or amino acid sequence for the biological molecule that is predicted by the conditional generator model to confer on the biological molecule the one or more target biological properties approximating the plurality of target metric values.

Abstract: Disclosed herein are engineered guide RNAs and compositions comprising the same for treatment of diseases or conditions in a subject. Also disclosed herein are methods of treating diseases or conditions in a subject by administering engineered guide RNAs or pharmaceutical compositions described herein.

Abstract: Antibody molecules that specifically bind to C5aR1 are disclosed. The antibody molecules can be used to treat, prevent, and/or diagnose disorders, such as ANCA-vasculitis.

Abstract: The present disclosure provides, among other things, two different formats of humanized antibodies against human complement component 5a receptor I. The disclosure also provides a method of treating a subject having dysfunctions of C5a/C5aR1 axis pathway, including but not limited to ANCA-associated vasculitis, comprising administering to the subject in need thereof an effective amount of antibody or a nucleic encoding an antibodies binding to C5aR1 described herein, and wherein administering results in a decrease in symptoms associated with C5a/C5aR1 associated dysfunction in the subject.

Abstract: The present disclosure provides, among other things, two different formats of humanized antibodies against human complement component 5a receptor I. The disclosure also provides a method of treating a subject having dysfunctions of C5a/C5aR1 axis pathway, including but not limited to ANCA-associated vasculitis, comprising administering to the subject in need thereof an effective amount of antibody or a nucleic encoding an antibodies binding to C5aR1 described herein, and wherein administering results in a decrease in symptoms associated with C5a/C5aR1 associated dysfunction in the subject.

Abstract: A system and method for remotely monitoring an aquatic device having an automated aquatic device controller are provided. The method includes connecting a wireless adapter to the automated aquatic device controller of the aquatic device and establishing a wireless connection between the wireless adapter, a user device, and a cloud based server. The cloud based server can determine when the aquatic device is due for maintenance, create a list of one or more materials for performing maintenance, generate trend data, and schedule a maintenance appointment.

Abstract: Antibody molecules that specifically bind to C5aR1 are disclosed. The antibody molecules can be used to treat, prevent, and/or diagnose disorders, such as ANCA-vasculitis.

Abstract: Provided herein is a high throughput screening method for identifying guide RNAs (gRNAs) useful for editing a target RNA, wherein the editing is mediated by an RNA editing entity (e.g., a native human adenosine deaminase enzyme for a human subject).

Abstract: Antibody molecules that specifically bind to C5aR1 are disclosed. The antibody molecules can be used to treat, prevent, and/or diagnose disorders, such as ANCA-vasculitis.

Abstract: A system for adapting a water softener for wireless communication is disclosed. In some embodiments, a system for adapting a water softener with a serial communication port for communication with a user via a remote server, an internet connection, and internet enabled device is provided, the system comprising: a wireless gateway device connected to a router; and a wireless adapter connected to the serial communication port, comprising: a gateway node; a transceiver; and a processor programmed to: establish a wireless connection with the wireless gateway; receive a first message from the water softener; cause the gateway node to modify the first message; cause the first modified message to be transmitted to the remote server via the wireless gateway; receive a second message from the remote server; modify the second message for output to the water softener; and transmit the second modified message to the water softener.

Abstract: The present disclosure provides, among other things, two different formats of humanized antibodies against human complement component 5a receptor I. The disclosure also provides a method of treating a subject having dysfunctions of C5a/C5aR1 axis pathway, including but not limited to ANCA-associated vasculitis, comprising administering to the subject in need thereof a an effective amount of antibody or a nucleic encoding an antibodies binding to C5aR1 described herein, and wherein administering results in a decrease in symptoms associated with C5a/C5aR1 associated dysfunction in the subject.

Abstract: Systems for monitoring a sump pump are provided. A system includes a power adapter designed to receive power from a power source. The power adapter is provided in the form of a controller establishing a wireless connection a wireless network and a housing having a first receptacle and a second receptacle. The first receptacle and the second receptacle are designed to accept a float-switch input and a sump pump input, respectively. The float-switch input and the sump pump input are electrically coupled to controller and the power source when accepted by the first receptacle and the second receptacle, respectively.

Abstract: Polypeptides, such as antibody molecules and fusion proteins, comprising an Fc region, are disclosed. The polypeptides can be used to treat, prevent, and/or diagnose disorders.

Abstract: Provided herein are engineered latent guide RNAs that bind target RNAs to form a guide-target RNA scaffold and are substrates for RNA editing entities, which chemically modify the base of a nucleotide of the target RNA. Also provided herein are compositions, vectors, and cells comprising the engineered latent guide RNAs disclosed herein and methods of use thereof.

Abstract: Systems and methods for monitoring operation of a sump pump are provided. A method includes connecting a power adapter to the sump pump and a float-switch. The power adapter includes a controller positioned within a housing, prongs in communication with components coupled to the controller, a first receptacle and a second receptacle. The controller is configured to establish a wireless connection to a first wireless network, and transmit a message to a remote server over the first wireless network. The controller is further configured to determine a power status of a float switch and control the pump based on power status of the float switch.