Abstract: A computer-implemented event statistic generation method for intrusion detection comprises processing a plurality of return signals from a coherent optical time domain reflectometer into time domain signals for each of a plurality of sensor bins, the plurality of return signals corresponding to a plurality of stimulation pulses injected into an optical sensor fiber during a time period.

Abstract: A computer-implemented event statistic generation method for intrusion detection comprises processing a plurality of return signals from a coherent optical time domain reflectometer into time domain signals for each of a plurality of sensor bins, the plurality of return signals corresponding to a plurality of stimulation pulses injected into an optical sensor fiber during a time period.

Abstract: A computer-implemented event statistic generation for intrusion detection comprises processing a plurality of return signals from a coherent optical time-domain reflectometer into time-domain signals for each of a plurality of sensor bins, the plurality of return signals corresponding to a plurality of stimulation pulses injected into an optical sensor fiber during a time period. For each sensor bin, transforming the respective time-domain signal into a corresponding frequency-domain signal, calculating, from the respective frequency-domain signal, a first signal power area of a first frequency band expected to contain system noise and a second signal power area of a second frequency band expected to contain any energy related to at least a first event; and generating an event statistic proportional to the ratio of the second signal power area to the first signal power area at least in part by dividing the second signal power area by the first signal power area.

Abstract: A computer-implemented event statistic generation for intrusion detection comprises processing a plurality of return signals from a coherent optical time-domain reflectometer into time-domain signals for each of a plurality of sensor bins, the plurality of return signals corresponding to a plurality of stimulation pulses injected into an optical sensor fiber during a time period. For each sensor bin, transforming the respective time-domain signal into a corresponding frequency-domain signal, calculating, from the respective frequency-domain signal, a first signal power area of a first frequency band expected to contain system noise and a second signal power area of a second frequency band expected to contain any energy related to at least a first event; and generating an event statistic proportional to the ratio of the second signal power area to the first signal power area at least in part by dividing the second signal power area by the first signal power area.

Abstract: A method is described for the reproducible quantification of biomarker expression, including biomarker expression in a tissue sample. Methods and systems are described whereby reproducible scores for biomarker expression are obtained independent of instrument, its location, or operator.

Abstract: The present invention relates generally to improved methods of defining areas or compartments within which biomarker expression is detected and quantified. In particular, the present invention relates to automated methods for delineating marker-defined compartments objectively with minimal operator intervention or decision making. The method provides for precise definition of tissue, cellular or subcellular compartments particularly in histological tissue sections in which to quantitatively analyzing protein expression.

Abstract: The present invention relates generally to improved methods of defining areas or compartments within which biomarker expression is detected and quantified. In particular, the present invention relates to automated methods for delineating marker-defined compartments objectively with minimal operator intervention or decision making. The method provides for precise definition of tissue, cellular or subcellular compartments particularly in histological tissue sections in which to quantitatively analyzing protein expression.

Abstract: A method is described for the reproducible quantification of biomarker expression, including biomarker expression in a tissue sample. Methods and systems are described whereby reproducible scores for biomarker expression are obtained independent of instrument, its location, or operator.

Abstract: The present invention relates generally to improved methods of defining areas or compartments within which biomarker expression is detected and quantified. In particular, the present invention relates to automated methods for delineating marker-defined compartments objectively with minimal operator intervention or decision making. The method provides for precise definition of tissue, cellular or subcellular compartments particularly in histological tissue sections in which to quantitatively analyzing protein expression.

Abstract: A method of analysing spectroscopic data, the method comprising collecting spatially resolved measurement spectroscopic data of a sample for a series of measurements spots, assigning the measurement spots into a predefined set of spectral categories, based on characteristics of the spectroscopic data of the respective measurement spots, identifying groupings of the measurement spots based on their respective spectral categories and their spatial relationships, and assigning each grouping of measurement spots to a fundamental sample unit data object.