Abstract: Systems, devices, and methods for deploying a graft to a treatment site of a patient. Exemplary systems operate to fix a graft to bone or soft tissue by placing multiple anchors through the graft in different locations, with individual anchors interconnected by sutures fixing the graft to the patient tissue. Exemplary anchor assemblies include an initial anchor with a suture permanently affixed, intermediate anchors through which the running suture can pass freely after placement, and a final anchor which locks the running suture under tension once placed.

Abstract: Systems, devices, and methods for deploying a graft to a treatment site of a patient. Exemplary systems include a device body and an insertion mechanism. The device body can have a handle and a trigger, and a controller. The insertion mechanism can be in operative association with the device body, and can have an outer sheath, a central shaft disposed at least partially within the outer sheath, an expansion mechanism in operative association with the central shaft, and a graft that can be deployed by the expansion mechanism.

Abstract: An orthopedic system for delivery of a therapeutic agent to a bone includes an elongate stem adapted to be inserted into an intramedullary canal, an inlet configured to receive the therapeutic agent, and one or more outlets configured to deliver the therapeutic agent to the bone. The elongate stem may comprise one or more protrusions to engage the bone, and one or more channels extending longitudinally therein, fluidly coupled to the inlet. The therapeutic agent flows from the inlet through the one or more channels and exits into the intramedullary canal through the one or more outlets. The system may be configured to allow one or more dimensions of the system to be adjusted to accommodate the anatomy of a patient.

Abstract: This invention provides protein stabilizing compounds, compositions, and methods of use thereof, that include a USP7 Targeting Ligand, a Protein Targeting Ligand, and optionally a Linker for the restoration of a Target Ubiquitinated Protein to treat a disorder mediated by deficiencies of the Target Protein.

Abstract: A root portion of a root-analog dental implant may include a core positioned in an approximate center of the root portion of the dental implant. The core may provide mechanical strength and/or support for the dental implant and may include one or more struts. The root-analog dental implant may further include a porous surface positioned on a portion of a vertically oriented exterior surface of the core. The struts may be configured and arranged to provide mechanical strength and/or support for the root-analog dental implant.

Abstract: Systems, devices, and methods for deploying a graft to a treatment site of a patient. Exemplary systems include a device body and an insertion mechanism. The device body can have a handle, a trigger, and a controller. The insertion mechanism can be in operative association with the device body, and can have an outer sheath, a support shaft disposed at least partially within the outer sheath, an expansion mechanism coupled with the support shaft, and a graft in contact with the expansion mechanism.

Abstract: Devices and methods for performing a cervical laminoplasty procedure on a patient. An exemplary device includes a primary instrument having a proximal portion and a distal portion, a secondary instrument having a distal portion, and an implant plate assembly having an implant plate and an implant post. The distal portion of the primary instrument can be configured to engage the implant post of the implant plate assembly. A lateral side of the implant plate can engage a lateral portion of a lamina of a vertebra, and a medial side of the implant plate can engage a medial portion of a lamina of a vertebra. The implant plate can be bent and a corresponding adjustment in an angle between the lateral and medial portions of the lamina can be achieved.

Abstract: Methods and systems are provided for a hinge knee system. A hinge knee system may comprise a femoral component; an insert; a tibial tray configured to be coupled to the insert; a tibial bushing configured to be disposed between the tibial tray and the insert; a poly locking screw configured to secure the tibial tray to the insert; a hinge box configured to be disposed between the femoral component and the insert; one or more cross-pin bushings configured to be disposed within the hinge box; a cross-pin configured to secure the hinge box to the femoral component; a hinge post configured to couple the hinge box to the tibial tray; and a hinge post set screw configured to secure the hinge box to the hinge post.

Abstract: A root portion of a root-analog dental implant may include a core positioned in an approximate center of the root portion of the dental implant. The core may provide mechanical strength and/or support for the dental implant and may include one or more struts. The root-analog dental implant may further include a porous surface positioned on a portion of a vertically oriented exterior surface of the core. The struts may be configured and arranged to provide mechanical strength and/or support for the root-analog dental implant.

Abstract: Systems, devices, and methods for deploying a graft to a treatment site of a patient. Exemplary systems include a device body and an insertion mechanism. The device body can have a handle, a trigger, and a controller. The insertion mechanism can be in operative association with the device body, and can have an outer sheath, a support shaft disposed at least partially within the outer sheath, an expansion mechanism coupled with the support shaft, and a graft in contact with the expansion mechanism.

Abstract: Devices and methods for fusing a sacroiliac joint of a patient. Exemplary fusion systems include an implant body and one or more screws. An implant body can have a medial side configured to engage a sacrum of a patient, a lateral side configured to engage an ilium of the patient, a distal portion, and a proximal portion having an opening configured to receive a screw. A screw can include a distal portion having a threaded portion configured to engage bone of the patient, and a proximal portion configured engage the opening in the proximal portion of the implant body.

Abstract: Apparatus and methods for providing spinal percutaneous delivery of an implant that can rigidly fixate the spinous process of a first superior bone and a second inferior bone of a functional spinal unit. In one aspect, the device comprises two bone abutment members connected via an interconnecting member. In another aspect, the method comprises implanting at least two spinal implant apparatus within a target disc space via an implantation apparatus. In another aspect, a placement instrument comprising an implant delivery segment, an anchor segment, and an articulating arm is disclosed.

Abstract: A root portion of a root-analog dental implant may include a core positioned in an approximate center of the root portion of the dental implant. The core may provide mechanical strength and/or support for the dental implant and may include one or more struts. The root-analog dental implant may further include a porous surface positioned on a portion of a vertically oriented exterior surface of the core. The struts may be configured and arranged to provide mechanical strength and/or support for the root-analog dental implant.

Abstract: Dental implants may be designed using a three-dimensional scan of an extracted tooth root and/or a corresponding socket site. The dental implant may include three portions: a root segment designed to sit below the patient's gum line, a connector portion positioned above the root segment and designed to sit above the gum line, and an abutment portion positioned above the connector portion upon which a temporary or permanent crown may be placed. The root segment may include three sections that correspond to three areas of a three-dimensional scan of an extracted tooth root. The first and third sections of the implant may have a size and shape that corresponds to a first and third portions of the three-dimensional scan, respectively. A circumference of the second section of the implant may be smaller than a corresponding circumference of the second section of the three-dimensional scan of the tooth root.

Abstract: Excess skin removal and wound closure devices, such as blepharoplasty devices and methods, are provided. An exemplary device for excising excess skin (e.g. eyelid skin) and creating wound closure includes a base, a lever mechanism coupled with the base via a lever pivot, a locking mechanism, an elongate curved first jaw member in fixed relationship with the base and having a lower serrated tissue contacting surface, an elongate curved second jaw member in movable relationship with the base and having an upper serrated tissue contacting surface. The upper serrated tissue contacting surface of the second jaw member can face toward the lower serrated tissue contacting surface of the first jaw member. The locking mechanism can be releasably engageable with the second jaw member. The pivoting actuation of the lever mechanism can cause linear movement of the second jaw member relative to the first jaw member.

Abstract: A graft tensioning tool includes an elongate frame having a proximal end, a distal end, and an axial passage extending therethrough. The distal end is configured to detachably engage a tunnel ring at an entrance to a tunnel in bone, and the frame includes a first suture puller and a second suture puller. Each suture puller detachably engages a length of suture emerging through the attached to suture and/or a soft tissue implant in the bone tunnel. A tensioner on the elongate frame displaces the suture pullers in a proximal direction to apply a controlled tension to the suture lengths and/or implant. A tension gauge measures tension applied to the suture pullers, and a locking tool is configured to engage the suture lock through the axial passage of the frame, allowing a user to fix the suture ends to bone when a target tension is attained.

Abstract: An implant and method for fixation of long bones. The implant provides rotational, longitudinal, and bending stability. The implant comprises one or more elongated members that span the intramedullary cavity of a long bone, a distal tip that expands radially relative to the long axis of the implant, and a locking mechanism at the proximal end of the implant.

Abstract: A device and method for treatment of post-operative surgical site wounds. The device includes a housing, a spool configured to rotate relative to the housing, and a catheter coupled to the spool. Rotating the spool in one direction winds the catheter about a column disposed on the spool, and enables the catheter to be retracted from the closed wound. In some embodiments, the device further includes a wound dressing disposed about a distal end of the catheter. In some embodiments, retracting the catheter from a closed wound enables a wound dressing to be retracted from the closed wound.

Abstract: An implant and method for fixation of long bones. The implant provides rotational, longitudinal, and bending stability. The implant comprises one or more elongated members that span the intramedullary cavity of a long bone, a distal tip that expands radially relative to the long axis of the implant, and a locking mechanism at the proximal end of the implant.

Abstract: An orthopedic system for delivery of a therapeutic agent to a bone includes an elongate stem adapted to be inserted into an intramedullary canal, an inlet configured to receive the therapeutic agent, and one or more outlets configured to deliver the therapeutic agent to the bone. The elongate stem may comprise one or more protrusions to engage the bone, and one or more channels extending longitudinally therein, fluidly coupled to the inlet. The therapeutic agent flows from the inlet through the one or more channels and exits into the intramedullary canal through the one or more outlets. The system may be configured to allow one or more dimensions of the system to be adjusted to accommodate the anatomy of a patient.