Abstract: Provided are binding molecules, such as TCRs or antigen binding fragments thereof and antibodies and antigen-binding fragments thereof, such as those that recognize or bind human papilloma virus (HPV) 16, including HPV 16 E6 and HPV 16 E7. Also provided are engineered cells containing such binding molecules, compositions containing the binding molecules or engineered cells, and methods of treatment, such as administration of the binding molecules, engineered cells, or compositions.

Abstract: Catheter blood pumps and methods of use and manufacture. The pumps may include an expandable and collapsible shroud that defines a blood lumen. The shroud may include a polymeric scaffold along at least a portion of a length of the shroud. The pumps may include one or more impellers.

Abstract: An illumination system detects a peak value of a voltage of a transformer supplying an LED module by analyzing the current value of the voltage and an on-time of the voltage. Based on the detected peak value, a property of the illumination system is adjusted.

Abstract: A bleed circuit is applied to a transformer based on a bleed-on time and a bleed-off time determined by monitoring an output voltage waveform of the transformer.

Abstract: A bleed circuit is applied to a transformer based on a bleed-on time and a bleed-off time determined by monitoring an output voltage waveform of the transformer.

Abstract: An illumination system detects a peak value of a voltage of a transformer supplying an LED module by analyzing the current value of the voltage and an on-time of the voltage. Based on the detected peak value, a property of the illumination system is adjusted.

Abstract: An illumination system detects a peak value of a voltage of a transformer supplying an LED module by analyzing the current value of the voltage and an on-time of the voltage. Based on the detected peak value, a property of the illumination system is adjusted.

Abstract: A bleed circuit is applied to a transformer based on a bleed-on time and a bleed-off time determined by monitoring an output voltage waveform of the transformer.

Abstract: The present disclosure provides an inhaler having a vibration element for aerosolizing medicament contained in a blister pack, wherein a plurality of individual blister packs are arranged in a rotary cassette that fits within a housing, and wherein the individual blister packs are dragged up into a clamping position between the vibration element and a piercing element. The motion of the blister pack is controlled by a rotary disk within the housing which further coordinates the movement of the piercing and vibrating elements for the piercing and deaggregation, respectively, of the individual blister packs.

Abstract: An illumination system detects a peak value of a voltage of a transformer supplying an LED module by analyzing the current value of the voltage and an on-time of the voltage. Based on the detected peak value, a property of the illumination system is adjusted.

Abstract: A bleed circuit is applied to a transformer based on a bleed-on time and a bleed-off time determined by monitoring an output voltage waveform of the transformer.

Abstract: A tissue electrode assembly includes a membrane configured to form an expandable, conformable body that is deployable in a patient. The assembly further includes a flexible circuit positioned on a surface of the membrane and comprising at least one base substrate layer, at least one insulating layer and at least one planar conducting layer. An electrically-conductive electrode covers at least a portion of the flexible circuit and a portion of the surface of the membrane not covered by the flexible circuit, wherein the electrically-conductive electrode is foldable upon itself with the membrane to a delivery conformation having a diameter suitable for minimally-invasive delivery of the assembly to the patient.

Abstract: The present invention is directed to a flexible expandable stent for implantation in a body lumen, such as a coronary artery. The stent generally includes a series of metallic cylindrical rings longitudinally aligned on a common axis of the stent and interconnected by a series of links which be polymeric or metallic. Varying configurations and patterns of the links provides longitudinal and flexural flexibility to the stent while maintaining sufficient column strength to space the cylindrical rings along the longitudinal axis. The metallic material forming the rings provides the necessary radial stiffness.

Abstract: The present disclosure provides an inhaler having a vibration element for aerosolizing medicament contained in a blister pack, wherein a plurality of individual blister packs are arranged in a rotary cassette that fits within a housing, and wherein the individual blister packs are dragged up into a clamping position between the vibration element and a piercing element. The motion of the blister pack is controlled by a rotary disk within the housing which further coordinates the movement of the piercing and vibrating elements for the piercing and deaggregation, respectively, of the individual blister packs.

Abstract: An apparatus for endovascularly replacing a patient's heart valve. In some embodiments, the apparatus includes a replacement heart valve implant comprising a valve and an expandable anchor; and a deployment tool adapted to endovascularly deliver the replacement heart valve implant to an implant site within the patient, the deployment tool comprising an actuator adapted to exert an axially directed force on the anchor. The invention also provides a method for endovascularly replacing a heart valve of a patient. In some embodiments, the method includes the steps of endovascularly delivering a replacement heart valve implant having a valve and an anchor to an implant site within the patient; and applying an axially directed force from an actuator outside of the patient to the anchor. In invention also provides deployment tools for performing the method.

Abstract: Methods and devices for assessing the operation of a replacement heart valve. The method includes endovascularly delivering a replacement heart valve to a vicinity of a heart valve in an unexpanded configuration, and assessing the operation of the replacement heart valve in the vicinity of the heart valve before fully expanding the replacement heart valve. Methods and devices for assessing the location of a replacement heart valve. The method includes endovascularly delivering a replacement heart valve to a vicinity of the heart valve in an unexpanded configuration, expanding the replacement heart valve to a partially deployed configuration, and assessing the location of the replacement heart valve in the vicinity of the heart valve before fully expanding the replacement heart valve.

Abstract: The present invention is directed to a flexible expandable stent for implantation in a body lumen, such as a coronary artery. The stent generally includes a series of metallic cylindrical rings longitudinally aligned on a common axis of the stent and interconnected by a series of links which be polymeric or metallic. Varying configurations and patterns of the links provides longitudinal and flexural flexibility to the stent while maintaining sufficient column strength to space the cylindrical rings along the longitudinal axis. The metallic material forming the rings provides the necessary radial stiffness.

Abstract: The present invention relates to apparatus and methods for endovascularly delivering and releasing a prosthesis, e.g., an aortic prosthesis, within and/or across a patient's native heart valve, referred to hereinafter as replacing the patient's heart valve. In some embodiments the delivery system comprises a plurality of first actuatable element adapted to engage a plurality of second elements in a first configuration to capture the implant within the delivery system, and wherein the plurality of first actuatable element are adapted to engage the plurality of second elements in a second configuration and to release the implant from the delivery system.

Abstract: The invention includes methods of and apparatus for endovascularly replacing a heart valve of a patient. One aspect of the invention provides a method including the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve in an unexpanded configuration; and applying an external non-hydraulic or non-pneumatic actuation force on the anchor to change the shape of the anchor, such as by applying proximally and/or distally directed force on the anchor using a releasable deployment tool to expand and contract the anchor or parts of the anchor.

Abstract: The invention includes methods of and apparatus for endovascularly replacing a heart valve of a patient. One aspect of the invention provides a method including the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve in an unexpanded configuration; and applying an external non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to change the shape of the anchor, such as by applying proximally and/or distally directed force on the anchor using a releasable deployment tool to expand and contract the anchor or parts of the anchor. Another aspect of the invention provides an apparatus including a replacement valve; an anchor; and a deployment tool comprising a plurality of anchor actuation elements adapted to apply a non-hydraulically expanding or non-pneumatically expanding actuation force on the anchor to reshape the anchor.