Abstract: The invention provides immunoconjugates of Formula (I): Ab-[L-D]p, comprising an antibody linked by conjugation to one or more STING agonist moieties. The invention also provides STING agonist-linker intermediate compounds comprising a reactive functional group. Such intermediate compositions are suitable substrates for formation of the immunoconjugates through a linker or linking moiety. The invention further provides methods of treating cancer with the immunoconjugates.

Abstract: A method for dynamically controlling an electrical load of a recreational vehicle, including: defining predetermined load-shed levels, each load-shed level corresponding to a reduced electrical power output level supplied to electrically-powered devices; defining a device load-priority for each of the devices; receiving and processing battery data to determine a health of the battery; determining a total current draw on the battery when the recreational vehicle is operating; measuring an electrical output of a vehicle power-generation system; determining a load-shed level based on the determined health of the battery, current draw and electrical output of the power-generation system, the load-shed level corresponding to one of the predetermined load-shed levels; and selectively reducing electrical power supplied from the power-generation system or the battery to at least one of the electrically-powered devices based on the first load-shed level and the load-priority of the at least one electrical device.

Abstract: The present invention relates to the synthesis of di(hydroxymethyl)tetrahydrofuran (DHMTHF) and the preparation of trans-enriched mixtures of DHMTHF. The invention further refers to polyester polyols which are obtained by reaction of cis/trans DHMTHF mixtures with a dicarboxylic acid. The invention further relates to polyurethanes and compositions containing a polyester polyol comprising DHMTHF, in particular to such polyurethane-containing (adhesive) compositions.

Abstract: The invention provides a method of controlling operation of a wind turbine having a tower. The method includes determining an overall control output including lateral oscillation control for dampening lateral oscillation of the tower, and using the overall control output to control wind turbine operation. The method further includes receiving lateral oscillation sensor data indicative of a level of lateral oscillation of the tower, determining a rated lateral oscillation control output in dependence on the received lateral oscillation data, and receiving an indication of yaw error of the wind turbine. A lateral oscillation control output included in the overall control output is determined to be de-rated from the rated lateral oscillation control output when the indicated yaw error is above a predetermined lower threshold level.

Abstract: STING pathway agonism has emerged as a potential therapeutic mechanism to stimulate an innate anti-tumor immune response. While in principle systemic administration of a STING agonist would have many therapeutic benefits, including the delivery of STING to all tumor lesions, such an approach may be limited by toxicity. Antibody-drug conjugates (ADCs) constitute a proven therapeutic modality that is ideally suited to enable systemic administration without associated toxicity concerns via a targeted delivery strategy. Herein, we demonstrate that systemically administered STING agonist ADCs have greater anti-tumor activity as well as greatly improved tolerability compared to an intravenously (IV) administered, unconjugated (free) agonist. We generated novel STING agonist ADCs by leveraging our Immunosynthen platform, in which the chemical scaffold for bioconjugation is optimized for the STING agonist, resulting in an ADC that has desirable physicochemical and drug-like properties.

Abstract: A snowmobile warning and control method for a snowmobile having an engine and a brake system, including: sensing a temperature of the brake system of the vehicle; determining that the temperature of the brake system is above a first predetermined temperature threshold; issuing a first brake-system temperature warning in response to the temperature of the brake system exceeding the first predetermined temperature threshold; determining that the temperature of the brake system is above a second predetermined temperature, the second predetermined temperature being greater than the first predetermined temperature; issuing a second brake-system temperature warning in response to the temperature of the brake system exceeding the second predetermined temperature threshold; and modifying an operation of the engine in response to the temperature of the brake system exceeding the second predetermined temperature threshold.

Abstract: The invention provides immunoconjugates of Formula I comprising an antibody linked by conjugation to one or more 2-amino-4-carboxamide-benzazepine derivatives. The invention also provides 2-amino-4-carboxamide-benzazepine derivative intermediate compositions comprising a reactive functional group. Such intermediate compositions are suitable substrates for formation of the immunoconjugates through a linker or linking moiety. The invention further provides methods of treating cancer with the immunoconjugates.

Abstract: Catheter blood pumps and methods of use and manufacture. The pumps may include an expandable and collapsible shroud that defines a blood lumen. The shroud may include a polymeric scaffold along at least a portion of a length of the shroud. The pumps may include one or more impellers.

Abstract: An illumination system detects a peak value of a voltage of a transformer supplying an LED module by analyzing the current value of the voltage and an on-time of the voltage. Based on the detected peak value, a property of the illumination system is adjusted.

Abstract: A bleed circuit is applied to a transformer based on a bleed-on time and a bleed-off time determined by monitoring an output voltage waveform of the transformer.

Abstract: A bleed circuit is applied to a transformer based on a bleed-on time and a bleed-off time determined by monitoring an output voltage waveform of the transformer.

Abstract: An illumination system detects a peak value of a voltage of a transformer supplying an LED module by analyzing the current value of the voltage and an on-time of the voltage. Based on the detected peak value, a property of the illumination system is adjusted.

Abstract: An illumination system detects a peak value of a voltage of a transformer supplying an LED module by analyzing the current value of the voltage and an on-time of the voltage. Based on the detected peak value, a property of the illumination system is adjusted.

Abstract: A bleed circuit is applied to a transformer based on a bleed-on time and a bleed-off time determined by monitoring an output voltage waveform of the transformer.

Abstract: The present disclosure provides an inhaler having a vibration element for aerosolizing medicament contained in a blister pack, wherein a plurality of individual blister packs are arranged in a rotary cassette that fits within a housing, and wherein the individual blister packs are dragged up into a clamping position between the vibration element and a piercing element. The motion of the blister pack is controlled by a rotary disk within the housing which further coordinates the movement of the piercing and vibrating elements for the piercing and deaggregation, respectively, of the individual blister packs.

Abstract: An illumination system detects a peak value of a voltage of a transformer supplying an LED module by analyzing the current value of the voltage and an on-time of the voltage. Based on the detected peak value, a property of the illumination system is adjusted.

Abstract: A bleed circuit is applied to a transformer based on a bleed-on time and a bleed-off time determined by monitoring an output voltage waveform of the transformer.

Abstract: A tissue electrode assembly includes a membrane configured to form an expandable, conformable body that is deployable in a patient. The assembly further includes a flexible circuit positioned on a surface of the membrane and comprising at least one base substrate layer, at least one insulating layer and at least one planar conducting layer. An electrically-conductive electrode covers at least a portion of the flexible circuit and a portion of the surface of the membrane not covered by the flexible circuit, wherein the electrically-conductive electrode is foldable upon itself with the membrane to a delivery conformation having a diameter suitable for minimally-invasive delivery of the assembly to the patient.

Abstract: The present invention is directed to a flexible expandable stent for implantation in a body lumen, such as a coronary artery. The stent generally includes a series of metallic cylindrical rings longitudinally aligned on a common axis of the stent and interconnected by a series of links which be polymeric or metallic. Varying configurations and patterns of the links provides longitudinal and flexural flexibility to the stent while maintaining sufficient column strength to space the cylindrical rings along the longitudinal axis. The metallic material forming the rings provides the necessary radial stiffness.

Abstract: The present disclosure provides an inhaler having a vibration element for aerosolizing medicament contained in a blister pack, wherein a plurality of individual blister packs are arranged in a rotary cassette that fits within a housing, and wherein the individual blister packs are dragged up into a clamping position between the vibration element and a piercing element. The motion of the blister pack is controlled by a rotary disk within the housing which further coordinates the movement of the piercing and vibrating elements for the piercing and deaggregation, respectively, of the individual blister packs.