Patents by Inventor Brian Budke

Brian Budke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecules inhibitors of RAD51
    Patent number: 10973819
    Abstract: Embodiments concern methods and small molecule compositions for selectively inhibiting RAD51-mediated D-loop formation while preserving RAD51's ability to form nucleoprotein filaments. The selective RAD51 D-loop formation activity inhibitors DNA repair while minimizing replication-associated toxicity in normal tissue.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: April 13, 2021
    Assignee: The University of Chicago
    Inventors: Philip Connell, Wei Lv, Brian Budke, Alan Kozikowski
  • Methods and compositions involving RAD51 inhibitors
    Patent number: 10912761
    Abstract: The present invention concerns methods and compositions involving inhibitors and of RAD51, a protein involved in homologous recombination. In some embodiments, there are methods for sensitizing cells to the effects of DNA damaging agents, which can have particular applications for cancer patients. In some embodiments of the invention, the RAD51 inhibitor is a small molecule that directly affects RAD51 activity, such as its ability to promote filament formation.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: February 9, 2021
    Assignee: THE UNIVERSITY OF CHICAGO
    Inventors: Philip P. Connell, Brian Budke, Jay H. Kalin, Michal Pawlowski, Alan P. Kozikowski
  • SMALL MOLECULES INHIBITORS OF RAD51
    Publication number: 20190083491
    Abstract: Embodiments concern methods and small molecule compositions for selectively inhibiting RAD51-mediated D-loop formation while preserving RAD51's ability to form nucleoprotein filaments. The selective RAD51 D-loop formation activity inhibitors DNA repair while minimizing replication-associated toxicity in normal tissue.
    Type: Application
    Filed: March 2, 2017
    Publication date: March 21, 2019
    Inventors: Philip Connell, Wei Lv, Brian Budke, Alan Kozikowski
  • METHODS OF TREATING CANCER USING RAD51 SMALL MOLECULE STIMULATORS
    Publication number: 20170014360
    Abstract: Methods of killing or inhibiting the growth cancer cells and tumors and of treating cancer by administering compounds that stimulate the activity of RAD51. Cells overexpressing RAD51 or with other imbalances in homologous recombination machinery are particularly susceptible targets of RAD51 stimulators.
    Type: Application
    Filed: March 10, 2015
    Publication date: January 19, 2017
    Inventors: Phillip P. CONNELL, Douglas K. BISHOP, Brian BUDKE, Ralph WEICHSELBAUM
  • METHODS AND COMPOSITIONS INVOLVING RAD51 INHIBITORS
    Publication number: 20150306069
    Abstract: The present invention concerns methods and compositions involving inhibitors and of RAD51, a protein involved in homologous recombination. In some embodiments, there are methods for sensitizing cells to the effects of DNA damaging agents, which can have particular applications for cancer patients. In some embodiments of the invention, the RAD51 inhibitor is a small molecule that directly affects RAD51 activity, such as its ability to promote filament formation.
    Type: Application
    Filed: November 27, 2013
    Publication date: October 29, 2015
    Applicant: THE UNIVERSITY OF CHICAGO
    Inventors: Philip P. Connell, Brian Budke, Jay H. Kalin, Michal Pawlowski, Alan P. Kozikowski