Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

Abstract: The present disclosure relates to pharmaceutical suspensions of triamcinolone acetonide, methods of producing such suspensions and methods of using of such suspensions. The pharmaceutical suspensions of the present disclosure are stable and suitable for administration by suprachoroidal injection through a 30-gauge microneedle.

Abstract: The invention relates to nucleic acids encoding dominant negative polypeptides comprising the a3 helix of CC2 region and the SUN domain of a SUN domain-containing protein that inhibit the LING complex. The specific embodiment relates to polypeptides of varying lengths derived from amino acids 404-812 of SUNI with a KDEL signal sequence. It also relates to methods of identifying a LING complex inhibitor and the use of said polypeptides for treating and preventing laminopathies, and diseases characterised by hyperlipidaemia.

Abstract: The present disclosure relates to pharmaceutical suspensions of triamcinolone acetonide, methods of producing such suspensions and methods of using of such suspensions. The pharmaceutical suspensions of the present disclosure are stable and suitable for administration by suprachoroidal injection through a 30-gauge microneedle.

Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

Abstract: In various embodiments of the present disclosure, playstyle patterns of players are learned and used to generate virtual representations (“bots”) of users. Systems and methods are disclosed that use game session data (e.g., metadata) from a plurality of game sessions of a game to learn playstyle patterns of users, based on user inputs of the user in view of variables presented within the game sessions. The game session data is applied to one or more machine learning models to learn playstyle patterns of the user for the game, and associated with a user profile of the user. Profile data representative of the user profile is then used to control or instantiate bots of the users, or of categories of users, according to the learned playstyle patterns.

Abstract: A vacuum cleaner attachment generally includes a cleaning element that floats relative to a suction conduit of the vacuum cleaner attachment. The cleaning element is supported on a support structure that is movably coupled to a housing and is biased towards a floor, for example, as a result of the weight of the cleaning element support structure. The cleaning element may be permanently attached to the support structure or may be a removable or disposable pad or sheet attached to the support structure. The floating cleaning element may be supported between the suction conduit and one or more wheels of the vacuum cleaner attachment. The vacuum cleaner attachment may be removably attached to a vacuum cleaner, for example, to be used interchangeably with other surface cleaning heads.

Abstract: Methods for the treatment and prevention of laminopathies and diseases characterised by hyperlipidemia through LING complex inhibition are disclosed. In particular, LING complex disruption by expression of dominant-negative LING complex proteins alleviates pathophysiology in Lmna mutation-associated muscular dystrophy, progeria, and dilated cardiomyopathy. In addition, LING complex disruption by expression of dominant-negative LING complex proteins also alleviates pathophysiology in mouse models of atherosclerosis and familial hypercholesterolemia.

Abstract: An adaptive sensor array system and method includes receiving one or more signals from a sensor array and compare the received signals to one or more object detection threshold values, determining if the robotic cleaner was moving along a travel path for a predetermined period of time, window W, in response to a determination that the robotic cleaner was operating in straight-line motion during the window W, calculating a value of the received detected signals from the sensor array during one or more calibration periods C of the window W, and adjusting one or more of the object detection threshold values based on the calculated value during the window W. A sum of all the calibration periods C during window W is less than a length of the window W. One of the calibration periods C may start at a beginning of the window W.

Abstract: The present disclosure relates to pharmaceutical suspensions of triamcinolone acetonide, methods of producing such suspensions and methods of using of such suspensions. The pharmaceutical suspensions of the present disclosure are stable and suitable for administration by suprachoroidal injection through a 30-gauge microneedle.

Abstract: A skill-based training system includes a processing system having a processor, memory coupled to the processor with executable instructions stored therein, and an input-output controller coupled to the processor and to input and output devices. The memory includes lesson plans that outline skill-based tasks and activities, and predetermined performance criteria. The processor is configured by the instructions to present interfaces on the output devices simulating a virtual training environment. The processor is configured to receive input signals representative of performing the tasks and activities in the virtual environment, and to evaluate the performance by comparing the performed tasks and activities to the criteria, to determine a score and to present the score on the output devices.

Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

Abstract: In various embodiments of the present disclosure, playstyle patterns of players are learned and used to generate virtual representations (“bots”) of users. Systems and methods are disclosed that use game session data (e.g., metadata) from a plurality of game sessions of a game to learn playstyle patterns of users, based on user inputs of the user in view of variables presented within the game sessions. The game session data is applied to one or more machine learning models to learn playstyle patterns of the user for the game, and associated with a user profile of the user. Profile data representative of the user profile is then used to control or instantiate bots of the users, or of categories of users, according to the learned playstyle patterns.

Abstract: In various embodiments of the present disclosure, playstyle patterns of players are learned and used to generate virtual representations (“bots”) of users. Systems and methods are disclosed that use game session data (e.g., metadata) from a plurality of game sessions of a game to learn playstyle patterns of users, based on user inputs of the user in view of variables presented within the game sessions. The game session data is applied to one or more machine learning models to learn playstyle patterns of the user for the game, and associated with a user profile of the user. Profile data representative of the user profile is then used to control or instantiate bots of the users, or of categories of users, according to the learned playstyle patterns.

Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

Abstract: In various embodiments of the present disclosure, playstyle patterns of players are learned and used to generate virtual representations (“bots”) of users. Systems and methods are disclosed that use game session data (e.g., metadata) from a plurality of game sessions of a game to learn playstyle patterns of users, based on user inputs of the user in view of variables presented within the game sessions. The game session data is applied to one or more machine learning models to learn playstyle patterns of the user for the game, and associated with a user profile of the user. Profile data representative of the user profile is then used to control or instantiate bots of the users, or of categories of users, according to the learned playstyle patterns.

Abstract: An adaptive sensor array system and method includes receiving one or more signals from a sensor array and compare the received signals to one or more object detection threshold values, determining if the robotic cleaner was moving along a travel path for a predetermined period of time, window W, in response to a determination that the robotic cleaner was operating in straight-line motion during the window W, calculating a value of the received detected signals from the sensor array during one or more calibration periods C of the window W, and adjusting one or more of the object detection threshold values based on the calculated value during the window W. A sum of all the calibration periods C during window W is less than a length of the window W. One of the calibration periods C may start at a beginning of the window W.

Abstract: A surface cleaning apparatus such as an extractor is operable in a floor cleaning mode which utilizes a floor cleaning fluid flow path. The surface cleaning apparatus is also operable in an above floor cleaning mode which utilizes a different above floor fluid flow path.

Abstract: A skill-based training system includes a processing system having a processor, memory coupled to the processor with executable instructions stored therein, and an input-output controller coupled to the processor and to input and output devices. The memory includes lesson plans that outline skill-based tasks and activities, and predetermined performance criteria. The processor is configured by the instructions to present interfaces on the output devices simulating a virtual training environment. The processor is configured to receive input signals representative of performing the tasks and activities in the virtual environment, and to evaluate the performance by comparing the performed tasks and activities to the criteria, to determine a score and to present the score on the output devices.

Abstract: A vacuum cleaner attachment generally includes a cleaning element that floats relative to a suction conduit of the vacuum cleaner attachment. The cleaning element is supported on a support structure that is movably coupled to a housing and is biased towards a floor, for example, as a result of the weight of the cleaning element support structure. The cleaning element may be permanently attached to the support structure or may be a removable or disposable pad or sheet attached to the support structure. The floating cleaning element may be supported between the suction conduit and one or more wheels of the vacuum cleaner attachment. The vacuum cleaner attachment may be removably attached to a vacuum cleaner, for example, to be used interchangeably with other surface cleaning heads.