Abstract: A method for determining pattern of inheritance in an embryo for a region of interest is provided, comprising receiving embryo, maternal and paternal sequence data; aligning the received sequence data to a reference genome; identifying a region of interest in the aligned embryo sequence data; identifying single nucleotide polymorphisms (SNPs) in the maternal sequence data, paternal sequence data, and the identified region of interest in the embryo sequence data; imputing missing gaps in the maternal sequence data and the paternal sequence data using an imputation reference; counting the number of SNPs that are common between the embryo and the mother/father in the identified region of interest for the embryo sequence data and a corresponding region on the maternal/paternal sequence data to determine a maternal/paternal contribution value; and classifying a pattern of inheritance for the embryo as maternal or paternal based on the relative contribution values between mother and father.

Abstract: A multi-legged equipment support, components thereof, and associated methods. The equipment support comprises a stand and an equipment holder. The stand includes a hub and multiple legs pivotable with respect to the hub. The legs are pivotable outward from stowed positions to preset operational pivoted positions. The user can select a preset operational pivoted position in which outward pivoting of a leg will stop based on moving an actuator between preset locations.

Abstract: An ammunition press for manufacturing or reloading ammunition cartridges. The ammunition press includes an adjustable shell holder for holding ammunition shells (sometimes called cases) of various sizes. A catch tray is provided for collecting spent primers or other debris. According to a user's preference, the ammunition press can be customized to provide an over-center actuated configuration or a non-over-center actuated configuration. A light is integrated with the press for illuminating the shell holder. Components of the press and associated methods are also disclosed.

Abstract: An ammunition press for manufacturing or reloading ammunition cartridges. The ammunition press includes an adjustable shell holder for holding ammunition shells (sometimes called cases) of various sizes. A catch tray is provided for collecting spent primers or other debris. According to a user's preference, the ammunition press can be customized to provide an over-center actuated configuration or a non-over-center actuated configuration. A light is integrated with the press for illuminating the shell holder. Components of the press and associated methods are also disclosed.

Abstract: An example method includes receiving task identification information indicative of a manufacturing task to be performed on a workpiece, wherein the workpiece transfer system comprises a rail and a plurality of arms coupled to the rail, wherein each arm comprises (i) a plurality of arm linkages coupled at respective joints, (ii) an arm controller in communication with the supervisory controller, and (iii) respective joint controllers in communication with the arm controller and configured to actuate respective rotary actuators at the respective joints to move the plurality of arm linkages relative to each other: retrieving a motion plan corresponding to the manufacturing task and the workpiece: sending command signals to respective arm controllers to communicate respective command signals to the respective joint controllers and execute the motion plan; and once the final desired configuration is achieved, commanding the respective arm controllers to lock the respective joints.

Abstract: Progressive ammunition press system, components thereof, and associated methods. The press system may include a press control system integrated with the press. The press may include a case carriage including a case carrier supported by a bearing. Case retainer gates may be provided for retaining cases in the case carrier. A bullet feeding system can be arranged to permit bullet feeding and seating in a single station of the press. A primer feeder can be self-contained, gear-driven, and/or recirculating.

Abstract: A knife comprising a handle and a blade assembly. The blade assembly includes a blade, a tang, and blade assembly connection structure. The handle includes a receiver configured to receive the tang, and includes handle connection structure. The blade assembly connection structure and handle connection structure are arranged to releasably lock the blade assembly in an installed position on the handle with the tang in the tang receiver.

Abstract: A digital signaling device provides visual, audible, and haptic indicators when the digital signaling device changes state. The digital signaling device has a same operational feel and response as a classic electro-mechanical decorator-style light switch, including maintaining switch paddle position, using attractive magnetic latching in combination with a spring contact. The switch paddle can be pressed into one of two positions, each position representing a different state of the digital signaling device. The switch paddle provides a visual indicator of the digital signaling device state in that the switch paddle is maintained in one of the two positions. The attractive magnetic latching provides both an audible and haptic indicator when the magnet pairs are engaged, which corresponds to a change of state of the digital signaling device. The spring contact provides a digital switching mechanism for changing the state of the digital signaling device.

Abstract: An out-the-front knife, components thereof, and associated methods. The out-the front knife can be a double-action spring-assisted knife. The knife includes a handle and a blade. The handle includes a rear end and a front opening opposite the rear end. The blade is movable with respect to the handle between stowed and deployed positions. In the stowed position, the blade is biased rearward. The knife includes an actuator movable in a deploying direction to spring the blade forward away from the stowed position toward the deployed position.

Abstract: An ammunition press for manufacturing or reloading ammunition cartridges. The ammunition press includes an adjustable shell holder for holding ammunition shells (sometimes called cases) of various sizes. A catch tray is provided for collecting spent primers or other debris. According to a user's preference, the ammunition press can be customized to provide an over-center actuated configuration or a non-over-center actuated configuration. A light is integrated with the press for illuminating the shell holder. Components of the press and associated methods are also disclosed.

Abstract: An ammunition press for manufacturing or reloading ammunition cartridges. The ammunition press includes an adjustable shell holder for holding ammunition shells (sometimes called cases) of various sizes. A catch tray is provided for collecting spent primers or other debris. According to a user's preference, the ammunition press can be customized to provide an over-center actuated configuration or a non-over-center actuated configuration. A light is integrated with the press for illuminating the shell holder. Components of the press and associated methods are also disclosed.

Abstract: In various embodiments of the present disclosure, playstyle patterns of players are learned and used to generate virtual representations (“bots”) of users. Systems and methods are disclosed that use game session data (e.g., metadata) from a plurality of game sessions of a game to learn playstyle patterns of users, based on user inputs of the user in view of variables presented within the game sessions. The game session data is applied to one or more machine learning models to learn playstyle patterns of the user for the game, and associated with a user profile of the user. Profile data representative of the user profile is then used to control or instantiate bots of the users, or of categories of users, according to the learned playstyle patterns.

Abstract: A vacuum cleaner attachment generally includes a cleaning element that floats relative to a suction conduit of the vacuum cleaner attachment. The cleaning element is supported on a support structure that is movably coupled to a housing and is biased towards a floor, for example, as a result of the weight of the cleaning element support structure. The cleaning element may be permanently attached to the support structure or may be a removable or disposable pad or sheet attached to the support structure. The floating cleaning element may be supported between the suction conduit and one or more wheels of the vacuum cleaner attachment. The vacuum cleaner attachment may be removably attached to a vacuum cleaner, for example, to be used interchangeably with other surface cleaning heads.

Abstract: Methods for the treatment and prevention of laminopathies and diseases characterised by hyperlipidemia through LING complex inhibition are disclosed. In particular, LING complex disruption by expression of dominant-negative LING complex proteins alleviates pathophysiology in Lmna mutation-associated muscular dystrophy, progeria, and dilated cardiomyopathy. In addition, LING complex disruption by expression of dominant-negative LING complex proteins also alleviates pathophysiology in mouse models of atherosclerosis and familial hypercholesterolemia.

Abstract: An adaptive sensor array system and method includes receiving one or more signals from a sensor array and compare the received signals to one or more object detection threshold values, determining if the robotic cleaner was moving along a travel path for a predetermined period of time, window W, in response to a determination that the robotic cleaner was operating in straight-line motion during the window W, calculating a value of the received detected signals from the sensor array during one or more calibration periods C of the window W, and adjusting one or more of the object detection threshold values based on the calculated value during the window W. A sum of all the calibration periods C during window W is less than a length of the window W. One of the calibration periods C may start at a beginning of the window W.

Abstract: The present disclosure relates to pharmaceutical suspensions of triamcinolone acetonide, methods of producing such suspensions and methods of using of such suspensions. The pharmaceutical suspensions of the present disclosure are stable and suitable for administration by suprachoroidal injection through a 30-gauge microneedle.

Abstract: A skill-based training system includes a processing system having a processor, memory coupled to the processor with executable instructions stored therein, and an input-output controller coupled to the processor and to input and output devices. The memory includes lesson plans that outline skill-based tasks and activities, and predetermined performance criteria. The processor is configured by the instructions to present interfaces on the output devices simulating a virtual training environment. The processor is configured to receive input signals representative of performing the tasks and activities in the virtual environment, and to evaluate the performance by comparing the performed tasks and activities to the criteria, to determine a score and to present the score on the output devices.

Abstract: Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

Abstract: In various embodiments of the present disclosure, playstyle patterns of players are learned and used to generate virtual representations (“bots”) of users. Systems and methods are disclosed that use game session data (e.g., metadata) from a plurality of game sessions of a game to learn playstyle patterns of users, based on user inputs of the user in view of variables presented within the game sessions. The game session data is applied to one or more machine learning models to learn playstyle patterns of the user for the game, and associated with a user profile of the user. Profile data representative of the user profile is then used to control or instantiate bots of the users, or of categories of users, according to the learned playstyle patterns.

Abstract: In various embodiments of the present disclosure, playstyle patterns of players are learned and used to generate virtual representations (“bots”) of users. Systems and methods are disclosed that use game session data (e.g., metadata) from a plurality of game sessions of a game to learn playstyle patterns of users, based on user inputs of the user in view of variables presented within the game sessions. The game session data is applied to one or more machine learning models to learn playstyle patterns of the user for the game, and associated with a user profile of the user. Profile data representative of the user profile is then used to control or instantiate bots of the users, or of categories of users, according to the learned playstyle patterns.