Abstract: A blood processing system includes a centrifuge and an optical monitoring system mounted at a stationary radial position with respect to the centrifuge. A flow circuit may be mounted within the centrifuge, with an umbilicus of the flow circuit extending outside of the centrifuge. A midsection of the umbilicus is orbited around a rotational axis of the centrifuge at a uniform first speed, which causes the centrifuge to rotate at a non-uniform second speed that is approximately double the first speed. The monitoring system is configured to view the flow circuit through a radial window of the centrifuge to determine a characteristic of the flow circuit. The yoke and/or umbilicus may occasionally move into position between the monitoring system and the window, so a controller of the monitoring system is configured to determine when unobstructed light reflected through the window by the centrifuge is received by the monitoring system.

Abstract: A system for performing an apheresis procedure on a human subject includes an apheresis device having a communication channel in communication with a data storage device remote from the apheresis treatment device, an input device configured to receive an identity input data, wherein the identity input data comprises a combination of data, and a processing circuit. The processing circuit is configured to compare the identity input data to an identity of a human subject downloaded from the data storage device and, if the combination of data is consistent with two or more subject-specific information for a subject data entry, to provide access to an apheresis procedure operated according to the pre-programmed parameters on the apheresis device. The processing circuit is configured to derive an operating parameter for the apheresis procedure based on at least one of the subject-specific information of the human subject and to operate the apheresis procedure using the derived operating parameter.

Abstract: Fluid separation chambers are provided for rotation about an axis in a fluid processing system. The fluid separation chamber may be provided with first and second stages, with the first and second stages being positioned at different axial locations. In another embodiment, at least one of the stages may be provided with a non-uniform outer diameter about the rotational axis, which may define a generally spiral-shaped profile or a different profile for fractionating a fluid or fluid component. One or more of the stages may also have a varying outer diameter along the axis. The profile of the chamber may be provided by the chamber itself (in the case of rigid chambers) or by an associated fixture or centrifuge apparatus (in the case of flexible chambers).

Abstract: Described are devices, methods, and systems for achieving occlusion of vascular vessels. Further described are certain reduced or low profile procedures and devices for the percutaneous occlusion of the saphenous vein, such as in the treatment of a varicose vein condition caused by venous reflux.

Abstract: Centrifuges are provided for rotating fluid separation chambers about an axis in a fluid processing system. The centrifuge may be provided with high- and low-G walls, with a gap defined between the high- and low-G walls. A first section of the gap may have a substantially uniform radius about the axis, while a second section of the gap may have a non-uniform radius about the axis. The radius of the second section of the gap about the axis at all locations is no larger than the radius of the first section of the gap about the axis. The high-G wall may comprise an inner surface of an outer bowl, while the low-G wall may comprise an outer surface of an inner spool. At least a portion of the second section of the gap may have a varying radius along the axis and/or be configured as a spiral.

Abstract: Systems and methods for performing a therapeutic red blood cell exchange procedure are disclosed. In one aspect, a system includes a first flow path for flowing whole blood from a patient. A separator communicates with the first flow path for separating at least red blood cells from plasma. Second and third flow paths communicate with the separator for respectively flowing the separated plasma and red blood cells from the separator. A flow controller is associated with the flow paths to control fluid communication between the flow paths. The controller is configured to perform the procedure to achieve a target fraction of patient cells remaining, target hematocrit, and a target patient fluid volume change at the completion of the procedure based on data input by the operator.

Abstract: Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.

Abstract: A system for performing an apheresis procedure on a human subject includes an apheresis device having a communication channel in communication with a data storage device remote from the apheresis treatment device, an input device configured to receive an identity input data, wherein the identity input data comprises a combination of data, and a processing circuit. The processing circuit is configured to compare the identity input data to an identity of a human subject downloaded from the data storage device and, if the combination of data is consistent with two or more subject-specific information for a subject data entry, to provide access to an apheresis procedure operated according to the pre-programmed parameters on the apheresis device. The processing circuit is configured to derive an operating parameter for the apheresis procedure based on at least one of the subject-specific information of the human subject and to operate the apheresis procedure using the derived operating parameter.

Abstract: An expandable prosthesis having an imageable structure comprising one or more elements visually distinguishable by an external (e.g., radiographic or ultrasonic) imaging system, the structure being located about a first axis that corresponds to a structural feature of the prosthesis that is configured to perform a specific function particular to that axis. The imageable structure is configured to assist in the rotational orientation of the prosthesis during placement within the implantation site. In one embodiment, the prosthesis comprises a venous valve that includes imageable elements or structure, such as a pair of radiopaque markers, that defines the orifice of the valve structure such that the orifice can be oriented with a particular anatomical feature under imaging, such as to align the orifice with the long axis of the vessel.

Abstract: A system and method processes blood donation data for presentation on an operator interface. A handheld computing device has a touch screen display and a processing circuit to provide an icon associated with an executable application on a first display screen, the icon configured to be positioned along with icons for other executable applications on the first display screen. The processing circuit is to retrieve an indication of a need for a particular blood component, wherein the particular blood component is selected from the group comprising whole blood, double red cells and plasma. The processing circuit is to provide the indication of the need for a particular blood component to the display. The processing circuit is to provide to the touch screen display a remaining time or a date the blood donor is next eligible to donate a blood component based on a donation eligibility guideline.

Abstract: Systems and methods are provided for performing a medical procedure with respect to a subject. A data storage location of the system is pre-programmed with a plurality of subject data entries, each having subject-specific information associated with it. A user interface receives an identity input from a subject, which corresponds to the identity of the subject. A controller is associated with the database and the user interface, and is programmed to compare the identity input to the subject data entries. If the identity input corresponds to the subject-specific information of a subject data entry, the controller commands a treatment device to perform a medical procedure with respect to the subject. Otherwise, if the identity input does not correspond to the subject-specific information of any of the subject data entries, the controller generates an error signal which prevents the performance of the medical procedure with respect to the subject.

Abstract: Methods are provided for collecting platelet-rich plasma. A disposable flow circuit is mounted to a fluid processing device having a fluid separation chamber and an injection device. A fluid containing plasma and platelets is continuously conveyed from a fluid source into the fluid separation chamber and processed to produce platelet-rich plasma. At least a portion of the platelet-rich plasma is automatically conveyed from the fluid separation chamber into the injection device, which is directly connected to a pump device such that at least a portion of the platelet-rich plasma from the fluid separation chamber is automatically conveyed into the pump device prior to being conveyed into the injection device. The injection device with the platelet-rich plasma is then detached from the disposable flow circuit.

Abstract: A fluid processing cassette and sensor coupling system is disclosed, comprising a cassette comprising a cap having an opening formed by an inner cylindrical wall having a first diameter, an outer cylindrical wall having a second diameter, and a contact surface connecting the inner and outer cylindrical walls. The contact surface includes a varying diameter that decreases from the second diameter to the first diameter. A sensor post comprises a ring disposed around a cylindrical body and is positioned to engage with the contact surface of the cap to form a seal.

Abstract: Methods are provided for identifying a disposable flow circuit in a blood processing system. At least a portion of the disposable flow circuit is positioned within a centrifuge that is rotatable about a rotational axis and has a high-G outer wall with a window facing radially away from the rotational axis. The disposable flow circuit is monitored through the window to detect the presence of an expected identification feature and/or an expected alignment feature. If the expected feature is detected, a blood separation procedure is initiated, with the procedure including monitoring the disposable flow circuit through the window to detect characteristics of a fluid within the disposable flow circuit. If the expected feature is not detected, an alarm condition is generated and initiation of the blood separation procedure is prevented.

Abstract: An optical monitoring system is provided for use with a blood processing system. The system includes a light source configured to illuminate a disposable flow circuit received in a centrifuge and a light detector configured to receive an image of the disposable flow circuit. A controller combines two or more of the images received by the light detector to generate a two-dimensional output. The output is used to control the separation of blood within the disposable flow circuit. The monitoring system may also be used to verify that the disposable flow circuit is suitable for use with the centrifuge or that the disposable flow circuit is properly aligned within the centrifuge. The monitoring system may be positioned outside of the centrifuge bucket which receives the centrifuge.

Abstract: A system and method processes blood donation data for presentation on an operator interface. A handheld computing device has a touch screen display and a processing circuit to provide an icon associated with an executable application on a first display screen, the icon configured to be positioned along with icons for other executable applications on the first display screen. The processing circuit is to retrieve an indication of a need for a particular blood component, wherein the particular blood component is selected from the group comprising whole blood, double red cells and plasma. The processing circuit is to provide the indication of the need for a particular blood component to the display. The processing circuit is to provide to the touch screen display a remaining time or a date the blood donor is next eligible to donate a blood component based on a donation eligibility guideline.

Abstract: An optical monitoring system is provided for use with a blood processing system having a yoke that rotates an umbilicus about a rotational axis at a first speed, which causes rotation of an associated centrifuge at a second speed about the rotational axis that is different from the first speed. The system includes a light source configured to illuminate a disposable flow circuit received in the centrifuge and a light detector configured to receive an image of the disposable flow circuit to detect the location of an interface between separated blood compenents within the disposable flow circuit. The monitoring system may be positioned outside of the centrifuge bucket which receives the centrifuge and is configured to be in a fully operational mode for interface detection only when a transparent portion of the centrifuge is visible to the monitoring system.

Abstract: Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.

Abstract: Centrifugation systems and methods are provided for separating blood into its constituent parts. Inner and outer walls of a centrifuge each include a projection which extends toward the other wall. A separation chamber is received in the centrifuge between the walls, with the chamber including an inlet port for flowing blood into the chamber, a plasma outlet port for flowing plasma out of the chamber, and a red cell outlet port for flowing red blood cells out of the chamber. With the chamber received in the centrifuge between the walls, the first projection extends into the path of separated blood components flowing toward the plasma outlet port and prevents cellular blood components from flowing into the plasma outlet port. The second projection extends into the path of separated blood components flowing toward the red cell outlet port and prevents plasma from flowing into the red cell outlet port.

Abstract: Systems and methods for performing a therapeutic red blood cell exchange procedure are disclosed. In one aspect, a system includes a first flow path for flowing whole blood from a patient. A separator communicates with the first flow path for separating at least red blood cells from plasma. Second and third flow paths communicate with the separator for respectively flowing the separated plasma and red blood cells from the separator. A flow controller is associated with the flow paths to control fluid communication between the flow paths. The controller is configured to perform the procedure to achieve a target fraction of patient cells remaining, target hematocrit, and a target patient fluid volume change at the completion of the procedure based on data input by the operator.