Abstract: A coating can be applied to an endolumenal wall of a medical device by positioning an optical fiber within the lumen, providing a photo-activated chemical to contact the endolumenal wall, supplying the optical fiber with radiation capable of activating the chemical within the lumen, and withdrawing the optical fiber from the lumen at a controlled rate while the radiation is being emitted from the optical fiber to activate the chemical in close proximity to the endolumenal wall.

Abstract: The disclosure relates to medical devices for implantation in a body vessel, and methods of using and making the same. A medical device can include a frame with one or more projections each having at least one edge extending from the surface of the frame, and a biocompatible, water-soluble removable material coated over at least a portion of the at least one edge. The projections can be barbs positioned to engage the interior wall of a body vessel or to attach a material, such as a valve leaflet or graft, to the frame. The removable material can be dissolved within a body vessel upon implantation, thereby exposing the at least one edge. Methods of making an implantable medical device and methods of treating a subject are also disclosed.

Abstract: Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. Embodiments of the invention relate to medical devices comprising a frame having a compliance that can change upon implantation of the medical device within the lumen of a body vessel. Controlled fracture or bioabsorption of frame material can, in some embodiments, increase the compliance of a frame after implantation. Medical devices comprising a frame and one or more valve members adapted to regulate fluid flow in a body vessel, such as a vein, are also provided.

Abstract: Intraluminal support frames for placement within a body vessel are provided. The support frames include a plurality of ring structures and first and second sets of connector segments. Connector segments of the first set join adjacent pairs of ring structures while connector segments of the second set join at least three ring structures.

Abstract: A prosthetic valve includes a support frame, a leaflet attached to the support frame, and a bioactive agent associated with the leaflet. A first free edge of the leaflet permits fluid flow through a body vessel in a first direction and substantially prevents fluid flow through the body vessel in a second, opposite direction. A second free edge of the leaflet at least partially defines an opening for permitting a controlled amount of fluid flow through the body vessel.

Abstract: Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. A medical device can include a frame with one or more projections each having at least one edge extending from the surface of the frame, and a biocompatible, water-soluble removable material coated over at least a portion of the at least one edge. The projections can be barbs positioned to engage the interior wall of a body vessel or to attach a material, such as a valve leaflet or graft, to the frame. The removable material can be dissolved within a body vessel upon implantation, thereby exposing the at least one edge. Methods of making an implantable medical device and methods of treating a subject are also disclosed.

Abstract: Prosthetic valves for regulating fluid flow through a body vessel are described. The valves include a valve member that includes at least a portion that is capable of moving to selectively permit and substantially prevent fluid flow through the body vessel, either alone or with one or more additional valve members. A cannula is associated with the valve and permits a controlled amount of fluid flow through the valve, such as retrograde flow while the valve member substantially prevents fluid flow through the body vessel.

Abstract: Exchangeable delivery systems, methods of making delivery systems, and methods of delivering a self-expandable prosthetic device are provided. Delivery systems according to embodiments of the invention include an elongate tubular member defining a passageway with a distal end defining an exchange port, and a distal tip member disposed at least partially within the distal end of the passageway. A pusher is disposed in the passageway to effect axial movement of the distal tip member.

Abstract: Delivery systems and methods of treatment are described. The delivery systems facilitate visualization, monitoring, or sensing of body vessel parameters, blood parameters, or an intraluminal medical device included in the delivery system prior to, during, or after deployment in a body vessel. A sensing apparatus associated with the delivery systems provide information relating to the body vessel and/or fluid within the body vessel that can be used for verification of placement, confirmation of intraluminal medical device function, and/or determination of the need for additional delivery steps, among other purposes. The information can also be used for verification of initial vessel sizing information.

Abstract: Medical devices with one or more bioactive agents are provided for regulating fluid flow through a body vessel. Medical devices according to the invention can comprise prosthetic valves that include a bioactive agent.

Abstract: Described are vascular valve devices having valve elements formed of flexible material and at least one removable frame element. Also described are methods for using such devices in the vascular system and in particular in the venous system to treat venous insufficiency.

Abstract: Described are devices, methods and systems useful for achieving occlusion of vascular vessels. Percutaneous procedures can be used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous reflux. Certain embodiments encompass the percutaneous delivery of an occlusion device inverted within a cannula, its deployment and filling, so as to occlude or obliterate a portion of a vascular vessel.

Abstract: The present invention provides self-expanding or otherwise expandable artificial valve prostheses for deployment within a bodily passageway, such as a vessel or duct of a patient. The valve prostheses include a support structure having an outer frame and supporting a valve leaflet.

Abstract: Described are devices, methods and systems useful for achieving occlusion of vascular vessels. Percutaneous procedures can be used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous reflux. Certain embodiments encompass the deployment and filling of an inflatable occlusion device via a percutaneous procedure, so as to occlude or obliterate a portion of a vascular vessel.

Abstract: Described are methods and systems for modifying vascular valves in order to reduce retrograde blood flow through the valves. Preferred methods include connecting vascular valve leaflets with at least one remodelable material, such that the valve leaflets become fused by the ingrowth of the patient's native tissue. Preferred remodelable materials include collagenous extracellular matrix material, such as small intestine submucosa.

Abstract: Described are devices, methods, and systems useful for deploying one or more occlusive prostheses within the vasculature of a patient. Illustrative devices can include a deployment tube or sheath that contains an occlusive prosthesis, wherein a segment of the sheath is reversible by a user so as to deploy the prosthesis from the sheath lumen within a bodily lumen of a patient.

Abstract: Described are vascular valve devices for implantation in a patient. The vascular valve devices are designed to compensate for the retraction characteristics of a remodelable material used to form one or more leaflets. Alternatively, or in addition, the devices are designed to reduce retraction of the remodelable leaflet-forming material. Further described are methods for preparing and using these vascular valve devices.

Abstract: The present invention, in one embodiment, provides an implantable intraluminal fluid flow control system comprising an interface and a flow-modifying device positioned at a flow-modifying effective distance from the interface within the lumen of a body vessel. In one embodiment, the invention relates to maintaining, regulating or varying the fluid flow within a body vessel to preserve, promote, alter or enhance remodeling of tissue at the interface. Remodeling can include the resorption and replacement of implanted remodelable material with autologous tissue. The interface can comprise remodelable material such as small intestine submucosa. In one embodiment, one or more interfaces are positioned at flow-modifying effective distances from one or more flow-modifying devices. Related medical devices, kits and methods of treatment are also provided in some embodiments.

Abstract: Described are methods and systems for modifying vascular valves in order to reduce retrograde blood flow through the valves. Preferred methods include connecting vascular valve leaflets with at least one remodelable material, such that the valve leaflets become fused by the ingrowth of the patient's native tissue. Preferred remodelable materials include collagenous extracellular matrix material, such as small intestine submucosa.

Abstract: Medical device delivery systems and associated methods are provided. Delivery systems according to the invention include an elongated tubular member and a body member, such as a dilator, disposed therein. An intraluminal medical device is disposed on the dilator and within the tubular member prior to deployment. The delivery system includes a means for separating two or more portions of the distal end of the tubular member that aids in deploying the intraluminal medical device from the delivery system by separating two or more portions of the tubular member from each other to facilitate release of the intraluminal medical device from the body member. Various structures can be used for means for separating, including a cutting ring, activateable material on the tubular member, or other suitable structure. The provided devices and methods reduce friction occuring from relative movement between the sheath and dilator during deployment.