Abstract: A surgical stapler includes a first stapler half including an anvil surface having a plurality of staple forming pockets, and a second stapler half configured to releasably couple with the first stapler half. The second stapler half is operable to deploy staples toward the anvil surface. The stapler also includes a projection positioned on one of the stapler halves and extending laterally relative to a longitudinal axis of the stapler. The stapler halves are configured to pivot relative to each other about the projection. The stapler further includes a locking member positioned on the other of the stapler halves. The locking member is configured to translate along the longitudinal axis of the stapler between a locked state in which the locking member selectively captures the projection and an unlocked state in which the locking member selectively releases the projection. The locking member is biased proximally toward the locked state.

Abstract: Vertical beverage dispensers including a vertical dispensing manifold for dispensing a beverage. The vertical dispensing manifold may include an input port coupled to one end of a vertical shaft and a dispensing nozzle coupled to the other end of the vertical shaft. The vertical shaft may include a hollow interior and a plurality of orifices for introducing ingredients into the hollow interior formed in the sidewall of the vertical shaft. The vertical shaft may define a vertical flow path for the flow of a base liquid from the input port, through the vertical shaft to combine with one or more ingredients, and to the dispensing nozzle. The flow of base liquid and ingredients within the vertical shaft may be uniform.

Abstract: Vertical beverage dispensers including a vertical dispensing manifold for dispensing a beverage. The vertical dispensing manifold may include an input port coupled to one end of a vertical shaft and a dispensing nozzle coupled to the other end of the vertical shaft. The vertical shaft may include a hollow interior and a plurality of orifices for introducing ingredients into the hollow interior formed in the sidewall of the vertical shaft. The vertical shaft may define a vertical flow path for the flow of a base liquid from the input port, through the vertical shaft to combine with one or more ingredients, and to the dispensing nozzle. The flow of base liquid and ingredients within the vertical shaft may be uniform.

Abstract: The present invention provides a cosmetic composition having a cosmetically acceptable vehicle and one or more gap junction inhibitors and/or one or more choline acetyl transferase (CAT) inhibitors in an amount effective for reducing the appearance of deep wrinkles on the skin. Also provided is a method of reducing the appearance of deep wrinkles on the skin, including the steps of topically applying to the skin the above cosmetic composition in an amount and for a period of time sufficient to reduce the appearance of deep wrinkles on the skin.

Abstract: A cartridge is provided that comprises a housing. The housing is configured to maintain a pouch within the housing. The cartridge comprises a top and a bottom. The cartridge comprises at least one top mating member at the top of the cartridge and at least one bottom mating member at the bottom of the cartridge. The at least one top mating member is asymmetric with the at least one bottom mating member. Each mating member is configured to match with a corresponding mating member of a cartridge frame or rack.

Abstract: A cartridge is provided that comprises a housing. The housing is configured to maintain a pouch within the housing. The cartridge comprises a top and a bottom. The cartridge comprises at least one top mating member at the top of the cartridge and at least one bottom mating member at the bottom of the cartridge. The at least one top mating member is asymmetric with the at least one bottom mating member. Each mating member is configured to match with a corresponding mating member of a cartridge frame or rack.

Abstract: An induction heatable server comprises a base element having top and bottom elements, said bottom element having a peripheral wall defining an upwardly opening cavity in which are disposed a heat retentive disc and a ring member which is bonded to the peripheral wall. A top element extends over the ring member and seals the cavity. The top element and ring member are bonded to the peripheral wall of the bottom element to preclude moisture penetration into the cavity.

Abstract: The present invention describes compositions and methods for treating, preventing and improving hyperpigmentation, or other unwanted pigmentation of the skin, or other unwanted skin condition, such as age spots, aged skin, skin discoloration, etc., wherein the compositions include siRNA-gene silencing oligomers specific for tyrosinase. The compositions are used to treat a broad variety of pigmentation conditions, and are preferably applied to the skin, or are delivered by directed means to a site in need thereof.

Abstract: A beverage dispensing apparatus includes a mixing chamber for mixing hot water, a beverage concentrate and cold water, as well as one or more additives. The hot water and cold water are supplied at a predetermined flow rate at a predetermined proportion, regardless of the pressure of the water supply. A water heater supplies the hot water within a specified pressure range and without significant entrapped air.

Abstract: An induction heatable server comprises a base element having top and bottom elements, said bottom element having a peripheral wall defining an upwardly opening cavity in which are disposed a heat retentive disc and a ring member which is bonded to the peripheral wall. A top element extends over the ring member and seals the cavity. The top element and ring member are bonded to the peripheral wall of the bottom element to preclude moisture penetration into the cavity.

Abstract: A beverage dispensing apparatus includes a mixing chamber for mixing hot water, a beverage concentrate and cold water, as well as one or more additives. The hot water and cold water are supplied at a predetermined flow rate at a predetermined proportion, regardless of the pressure of the water supply. A water heater supplies the hot water within a specified pressure range and without significant entrapped air.

Abstract: The present invention describes compositions and methods for treating, preventing and improving hyperpigmentation, or other unwanted pigmentation of the skin, or other unwanted skin condition, such as age spots, aged skin, skin discoloration, etc., wherein the compositions include siRNA-gene silencing oligomers specific for tyrosinase. The compositions are used to treat a broad variety of pigmentation conditions, and are preferably applied to the skin, or are delivered by directed means to a site in need thereof.

Abstract: An induction heatable server comprises a base element having a bottom wall and a peripheral wall defining an upwardly opening cavity in which are disposed a heat retentive disc and a ring member which is bonded to the peripheral wall. A top element extends over the ring member and seals the cavity. The top element is bonded to the peripheral wall of the base element and the ring member to preclude moisture penetration into the cavity.

Abstract: The present invention describes compositions and methods for treating, preventing and improving hyperpigmentation, or other unwanted pigmentation of the skin, or other unwanted skin condition, such as age spots, aged skin, skin discoloration, etc., wherein the compositions include siRNA-gene silencing oligomers specific for tyrosinase. The compositions are used to treat a broad variety of pigmentation conditions, and are preferably applied to the skin, or are delivered by directed means to a site in need thereof.

Abstract: The present invention relates to a mixing chamber for producing a non-carbonated tea beverage, wherein the tea beverage is susceptible to growth of detrimental microorganisms, comprising: a tea concentrate feed line having a check valve; a hot water feed line; a cold water feed line having a check valve; and wherein the non-carbonated tea beverage is better than an acceptable microbial count and is a substantially homogeneous non-carbonated tea beverage.

Abstract: There is provided a composition having at least one of the following active extracts Butea frondosa, Naringi crenulata, Stenoloma chusana, or any combinations thereof. There is also provided a composition having at least one of the following additional extracts Azadirachta indica, Glycyrrhiza glabra linn., Morinda citrifolia, tomato glycolipid or any combinations thereof in combination with one or more of the active extracts. The compositions and methods of the invention are effective to lighten hair, skin, lips and/or nails.

Abstract: The invention relates to topical compositions containing components of plants from the Purslane family and methods for improving the aesthetic appearance of skin, particularly, preventing, ameliorating, treating and/or reducing fine lines and/or wrinkles. More particularly, the present invention relates to the use of topical compositions containing extract from the Portulaca oleracea plant to treat signs of dermatological aging, especially facial lines and deep wrinkles, and/or improve the aesthetic appearance of the skin. Preferably, the composition is applied once daily to the skin.

Abstract: A beverage dispensing apparatus includes a dispensing device, at least one valve that distributes a diluent, a concentrate pump that distributes concentrate, a support structure that supports the foregoing components and exterior cladding attached to the support structure. The exterior cladding provides the appearance of a real leaf tea brewer. The diluent valve and concentrate pump distribute the diluent and concentrate into the dispensing device to form a mixture to be dispensed therefrom. The diluent can be hot water and the apparatus further includes an air ejector device for eliminating air bubbles from the hot water prior to mixing. In addition, an improved sensor can accurately determine when the supply of concentrate is depleted.