Patents by Inventor Brian C. Kelley
Brian C. Kelley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11904289Abstract: Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutiType: GrantFiled: December 22, 2020Date of Patent: February 20, 2024Assignee: Cardinal Health 414, LLCInventors: Dennis Eshima, Mehmet Husnu, James Stone, Derrick Alcaide, Joseph E. Zambanini, Thomas A. Klausing, Chad E. Bouton, Henry Padgett, Brian C. Kelley, Scott N. Danhof, David A. Holley, Jeffrey T. Stroup, James B. Gleeson, Eric Hassenpflug, James A. Prescott, Herman Benecke, Daniel B. Garbark
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Publication number: 20210187467Abstract: Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutiType: ApplicationFiled: December 22, 2020Publication date: June 24, 2021Inventors: Dennis ESHIMA, Mehmet HUSNU, James STONE, Derrick ALCAIDE, Joseph E. ZAMBANINI, Thomas A. KLAUSING, Chad E. BOUTON, Henry PADGETT, Brian C. KELLEY, Scott N. DANHOF, David A. HOLLEY, Jeffrey T. STROUP, James B. GLEESON, Eric HASSENPFLUG, James A. PRESCOTT, Herman BENECKE, Daniel B. GARBARK
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Patent number: 10906020Abstract: Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutiType: GrantFiled: September 30, 2015Date of Patent: February 2, 2021Assignee: CARDINAL HEALTH 414, LLCInventors: Dennis Eshima, Mehmet Husnu, James Stone, Derrick Alcaide, Joseph E. Zambanini, Thomas A. Klausing, Chad E. Bouton, Henry Padgett, Brian C. Kelley, Scott N. Danhof, David A. Holley, Jeffrey T. Stroup, James B. Gleeson, Eric Hassenpflug, James A. Prescott, Herman Benecke, Daniel B. Garbark
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Publication number: 20160263545Abstract: Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutiType: ApplicationFiled: September 30, 2015Publication date: September 15, 2016Applicant: CARDINAL HEALTH 414, LLCInventors: DENNIS ESHIMA, MEHMET HUSNU, JIM STONE, DERRICK ALCAIDE, JOSEPH E. ZAMBANINI, THOMAS A. KLAUSING, CHAD E. BOUTON, HENRY PADGETT, BRIAN C. KELLEY, SCOTT N. DANHOF, DAVID A. HOLLEY, JEFFREY T. STROUP, JAMES B. GLEESON, ERIC HASSENPFLUG, JAMES A. PRESCOTT, HERMAN BENECKE, DANIEL B. GARBARK
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Publication number: 20160001246Abstract: Compact modular cassette systems and methods for the synthesis of radiopharmaceutical products are provided, the compact modular cassette system including a modular unit having valve plates, a reaction cassette, a reagent pack, and other seal and connector plates to ensure that reagents can be mixed together inside one or more chambers of the reaction cassette in a timely and efficient manner. When a new chamber for each new reaction or process should be used, a valveless modular system having removable reaction cassettes and the reagent packs may be used. In such a system, the reagent container, the reaction cassette, or both, can be removed from the modular cassette system and discarded after a desired reaction or process has taken place.Type: ApplicationFiled: March 2, 2015Publication date: January 7, 2016Applicant: CARDINAL HEALTH 414, LLCInventors: THOMAS A. KLAUSING, BRIAN C. KELLEY, JOSEPH E. ZAMBANINI, DAVID A. HOLLEY, JEFFREY T. STROUP
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Publication number: 20150088089Abstract: An apparatus (10) includes a body (2), a plunger (5), and an occlusion (4). The body is able to hold one or more medical substances therein. The body defines a longitudinal axis extending therethrough. The plunger is positioned within a portion of the body and is able to axially advance along the longitudinal axis. The plunger also defines an opening extending therethrough. The occlusion is able to extend through at least a portion of the opening of the plunger so that the plunger and the occlusion fluidly divide the body. The plunger is able to exert a first outward force against the body. The plunger is able to exert a second outward force against the body when the occlusion has been removed where the second outward force is less than the first outward force.Type: ApplicationFiled: April 26, 2013Publication date: March 26, 2015Inventors: Rush L. Bartlett, II, Peter M. Greco, Kevin D. Predmore, Brian C. Kelley, Joseph D. Dennis, Christopher P. McKenzie
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Publication number: 20130102772Abstract: Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutiType: ApplicationFiled: July 16, 2012Publication date: April 25, 2013Applicant: CARDINAL HEALTH 414, LLCInventors: Dennis ESHIMA, Mehmet Husnu, Jim Stone, Derrick Alcaide, Henry Padgett, Joseph E. Zambanini, Thomas A. Klausing, Chad E. Bouton, Brian C. Kelley, Scott N. Danhof, David A. Holley, Jeffrey T. Stroup, James B. Gleeson, Eric Hassenpflug, James A. Prescott, Herman Benecke, Daniel B. Garbark
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Publication number: 20130060017Abstract: The invention relates to methods for synthesizing compounds on solid supports. The invention also relates to synthesizing labeled compounds, such as those used in the field of radiopharmaceuticals. The invention relates to methods for synthesizing halogenated radiopharmaceuticals such as fludeoxyglucose (also known as fluorodeoxyglucose or FDG).Type: ApplicationFiled: July 16, 2012Publication date: March 7, 2013Applicant: CARDINAL HEALTH 414, LLCInventors: Dennis ESHIMA, Mehmet HUSNU, Jim STONE, Brian C. KELLEY
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Publication number: 20130020727Abstract: Compact modular cassette systems and methods for the synthesis of radiopharmaceutical products are provided, the compact modular cassette system including a modular unit having valve plates, a reaction cassette, a reagent pack, and other seal and connector plates to ensure that reagents can be mixed together inside one or more chambers of the reaction cassette in a timely and efficient manner. When a new chamber for each new reaction or process should be used, a valveless modular system having removable reaction cassettes and the reagent packs may be used. In such a system, the reagent container, the reaction cassette, or both, can be removed from the modular cassette system and discarded after a desired reaction or process has taken place.Type: ApplicationFiled: July 16, 2012Publication date: January 24, 2013Applicant: CARDINAL HEALTH 414, LLC.Inventors: Thomas A. KLAUSING, Jeffrey T. STROUP, Brian C. KELLEY, Joseph E. ZAMBANINI, David A. HOLLEY
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Patent number: 8133241Abstract: The present invention relates to a one-step fastening device, a process for creating a fastener utilizing such a device, and the end fastener produced thereby. In this regard, the invention uses an outer, hollow fastener material that can be partially compressed under tension at designated areas (i.e., a compression member) and an inner activation or tensioning member. The compression of the outer fastener material occurs at one or more flexible areas or compression features specifically located on the longitudinal axis of the material. As a result, the outer compression member is capable of being distorted or bent under tension to produce a predetermined configuration. The device described herein has the ability to form specific and controllable fasteners of designated shapes and configurations. Methods for fastening, snaring, gripping, cutting, and manipulating material using the device in a confined space are also provided.Type: GrantFiled: December 10, 2003Date of Patent: March 13, 2012Assignee: Battelle Memorial InstituteInventors: Robert R. Boyd, B. Matt Bartilson, William T. Hanna, Lynn Faulkner, Thomas D. Haubert, C. Michael Gegenheimer, Holly A. Stein, Jean E. Schelhorn, James B. Gleeson, Mary Hoffman Pancake, Brian C. Kelley, Roger W. Smith, Kevin M. Taylor, Dov S. Rosenberg, Wayne L. Poll
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Publication number: 20080086854Abstract: The present invention relates to a one-step fastening device, a process for creating a fastener utilizing such a device, and the end fastener produced thereby. In this regard, the invention uses an outer, hollow fastener material that can be partially compressed under tension at designated areas (i.e., a compression member) and an inner activation or tensioning member. The compression of the outer fastener material occurs at one or more flexible areas or compression features specifically located on the longitudinal axis of the material. As a result, the outer compression member is capable of being distorted or bent under tension to produce a predetermined configuration. The device described herein has the ability to form specific and controllable fasteners of designated shapes and configurations. Methods for fastening, snaring, gripping, cutting, and manipulating material using the device in a confined space are also provided.Type: ApplicationFiled: December 10, 2003Publication date: April 17, 2008Inventors: Robert R. Boyd, B.Matt Bartilson, William T. Hanna, Lynn Faulkner, Thomas D. Haubert, C.Michael Gegenheimer, Holly A. Stein, Jean E. Schelhorn, James B. Gleeson, Mary Hoffman Pancake, Brian C. Kelley, Roger W. Smith, Kevin M. Taylor, Dov S. Rosenberg, Wayne L. Poll
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Patent number: 5238055Abstract: An apparatus for cleaning deposits from heat exchange tubes in a boiler through the application of high frequency shock energy. The apparatus includes a tie bar which extends transverse of a row of heat exchange tubes in the boiler. A plurality of paired tube plates whose mounting positions are individually gaged from the tubes, are mounted to the tie bar and extend transversely from both the tie bar and the tubes. Plates are provided in pairs so as to have at least part of a row of the tubes firmly clamped therebetween. In this manner, the invention is readily mounted to existing banks of heat exchange tubes without requiring prior or precise knowledge as to the spacing between the tubes. Once properly positioned, the tube plates are fixedly secured to the tie bar.Type: GrantFiled: May 13, 1992Date of Patent: August 24, 1993Assignee: The Babcock & Wilcox CompanyInventor: Brian C. Kelley