Patents by Inventor Brian C. Schaefer

Brian C. Schaefer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immortalization of splenic and peripheral blood macrophages using a multi-cistronic v-raf/v-myc lentivirus
    Patent number: 12365917
    Abstract: Vectors and methods are disclosed for immortalizing mammalian cells by co-expression of v-raf and v-myc proteins. A replication-defective viral vector is used for improved safety. The vector comprises an optional marker gene, and is especially useful for producing an immortalized macrophage by a method that involves contacting the vector with a monocyte, proliferatively growing the monocyte, growing the monocytic cell on a solid surface, and then growing the monocytic cell on a porous surface. An immortalized macrophage is also disclosed.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: July 22, 2025
    Assignee: THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
    Inventors: Brian C. Schaefer, Chelsi Beauregard
  • Immortalization of Splenic and Peripheral Blood Macrophages Using a Multi-Cistronic V-RAF/V-MYC Lentivirus
    Publication number: 20210017540
    Abstract: Vectors and methods are disclosed for immortalizing mammalian cells by co-expression of v-raf and v-myc proteins. A replication-defective viral vector is used for improved safety. The vector comprises an optional marker gene, and is especially useful for producing an immortalized macrophage by a method that involves contacting the vector with a monocyte, proliferatively growing the monocyte, growing the monocytic cell on a solid surface, and then growing the monocytic cell on a porous surface. An immortalized macrophage is also disclosed.
    Type: Application
    Filed: March 19, 2019
    Publication date: January 21, 2021
    Applicant: The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Inventors: Brian C. Schaefer, Chelsi Beauregard
  • Method to identify regulators of cellular activation using Bcl10
    Patent number: 7169570
    Abstract: Disclosed are methods for evaluating the activation of Bcl10 in a cell in response to a putative stimulus, as well as methods for evaluating or identifying a regulatory compound which regulates activation of Bcl10-mediated signal transduction. These methods utilize the discovery of the activation-dependent formation in a cell of Bcl10 aggregates in a cell.
    Type: Grant
    Filed: March 4, 2004
    Date of Patent: January 30, 2007
    Assignee: National Jewish Medical and Research Center
    Inventors: Brian C. Schaefer, Philippa Marrack, John W. Kappler
  • Method to identify regulators of cellular activation using Bcl10
    Publication number: 20040265915
    Abstract: Disclosed are methods for evaluating the activation of Bcl10 in a cell in response to a putative stimulus, as well as methods for evaluating or identifying a regulatory compound which regulates activation of Bcl10-mediated signal transduction. These methods utilize the discovery of the activation-dependent formation in a cell of Bcl10 aggregates in a cell.
    Type: Application
    Filed: March 4, 2004
    Publication date: December 30, 2004
    Inventors: Brian C. Schaefer, Philippa Marrack, John W. Kappler