Patents by Inventor Brian C. Schutte

Brian C. Schutte has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Variant TLR4 nucleic acid and uses thereof
    Patent number: 7785794
    Abstract: The invention provides methods to identify polymorphisms at the human TLR4 locus, as well as methods to identify individuals at risk of indications that increase their morbidity and mortality.
    Type: Grant
    Filed: February 4, 2009
    Date of Patent: August 31, 2010
    Assignee: University of Iowa Research Foundation
    Inventors: David A. Schwartz, Brian C. Schutte
  • VARIANT TLR4 NUCLEIC ACID AND USES THEREOF
    Publication number: 20090258361
    Abstract: The invention provides methods to identify polymorphisms at the human TLR4 locus, as well as methods to identify individuals at risk of indications that increase their morbidity and mortality.
    Type: Application
    Filed: February 4, 2009
    Publication date: October 15, 2009
    Inventors: David A. Schwartz, Brian C. Schutte
  • Variant TLR4 nucleic acid and uses thereof
    Patent number: 7498151
    Abstract: The invention provides methods to identify polymorphisms at the human TLR4 locus, as well as methods to identify individuals at risk of indications that increase their morbidity and mortality.
    Type: Grant
    Filed: September 7, 2006
    Date of Patent: March 3, 2009
    Assignee: University of Iowa Research Foundation
    Inventors: David A. Schwartz, Brian C. Schutte
  • Use of ClC3 chloride channel blockers to modulate vascular tone
    Patent number: 7393864
    Abstract: The present invention provides methods for the modulation of vascular tone in a patient having compromised vascular tissue, which methods comprise the administration of a chloride channel blocking agent or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 15, 2001
    Date of Patent: July 1, 2008
    Assignee: University of Iowa Research Foundation
    Inventors: Fred S. Lamb, Brian C. Schutte, Baoli Yang
  • Variant TLR4 nucleic acid and uses thereof
    Patent number: 7141367
    Abstract: The invention provides methods to identify polymorphisms at the human TLR4 locus, as well as methods to identify individuals at risk of indications that increase their morbidity and mortality.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: November 28, 2006
    Assignee: University of Iowa Research Foundation
    Inventors: David A. Schwartz, Brian C. Schutte, Eva Lorenz
  • Human beta-defensin-3 (HBD-3), a highly cationic beta-defensin antimicrobial peptide
    Patent number: 6809181
    Abstract: The present invention relates a novel antimicrobial peptide HBD-3 and derivatives thereof as well as the gene encoding the peptide. The invention further relates to methods of use of the HBD-3 peptide including a method of inhibiting microbial growth by administering an effective amount of the HBD-3 peptide alone or in combinination with other antimicrobial agents or antibiotics. In addition, the immunomodulatory properties of the HBD-3 peptide also facilitate the manipulation of the immune response, i.e., as a chemoattractant for immature dentritic cells or memory T cells.
    Type: Grant
    Filed: June 1, 2001
    Date of Patent: October 26, 2004
    Assignee: University of Iowa Research Foundation
    Inventors: Paul B. McCray, Jr., Brian F. Tack, Hong Peng Jia, Brian C. Schutte
  • Variant TLR4 nucleic acid and uses thereof
    Patent number: 6740487
    Abstract: The invention provides methods to identify polymorphisms at the human TLR4 locus, as well as methods to identify individuals at risk of indications that increase their morbidity and mortality.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: May 25, 2004
    Assignee: University of Iowa Research Foundation
    Inventors: David A. Schwartz, Brian C. Schutte
  • Human and mouse beta-defensins, antimicrobial peptides
    Publication number: 20030176652
    Abstract: The present invention employs an iterative application of BLAST and Hidden Markov Model (HMM) based searches which identified 34 &bgr;-defensin genes in the human genome and 48 in the mouse genome. The present invention relates to novel antimicrobial peptides and derivatives thereof as well as the &bgr;-defensin genes encoding the peptides. The invention further relates to methods of use of the peptides including a method of inhibiting microbial growth by administering an effective amount of the peptide alone or in combination with other antimicrobial agents or antibiotics.
    Type: Application
    Filed: September 23, 2002
    Publication date: September 18, 2003
    Inventors: Paul B. McCray, Brian C. Schutte, Hong Peng Jia, Thomas L. Casavant, Michael J. Welsh
  • Variant TLR4 nucleic acid and uses thereof
    Publication number: 20020173001
    Abstract: The invention provides methods to identify polymorphisms at the human TLR4 locus, as well as methods to identify individuals at risk of indications that increase their morbidity and mortality.
    Type: Application
    Filed: December 7, 2001
    Publication date: November 21, 2002
    Applicant: University of Iowa Research Foundation
    Inventors: David A. Schwartz, Brian C. Schutte, Eva Lorenz
  • Human beta-defensin-3 (HBD-3), a highly cationic beta-defensin antimicrobial peptide
    Publication number: 20020115602
    Abstract: The present invention relates a novel antimicrobial peptide HBD-3 and derivatives thereof as well as the gene encoding the peptide. The invention further relates to methods of use of the HBD-3 peptide including a method of inhibiting microbial growth by administering an effective amount of the HBD-3 peptide alone or in combinination with other antimicrobial agents or antibiotics. In addition, the immunomodulatory properties of the HBD-3 peptide also facilitate the manipulation of the immune response, i.e., as a chemoattractant for immature dentritic cells or memory T cells.
    Type: Application
    Filed: June 1, 2001
    Publication date: August 22, 2002
    Inventors: Paul B. McCray, Brian F. Tack, Hong Peng Jia, Brian C. Schutte
  • Use of CLC3 chloride channel blockers to modulate vascular tone
    Publication number: 20020065325
    Abstract: The present invention provides methods for the modulation of vascular tone in a patient having compromised vascular tissue, which methods comprise the administration of a chloride channel blocking agent or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 15, 2001
    Publication date: May 30, 2002
    Inventors: Fred S. Lamb, Brian C. Schutte, Baoli Yang