Patents by Inventor Brian C. Stewart

Brian C. Stewart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190389968
    Abstract: The present invention is directed to antibodies and fragments thereof having binding specificity for PCSK9. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-PCSK9 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-PCSK9 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-PCSK9 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with PCSK9.
    Type: Application
    Filed: March 6, 2019
    Publication date: December 26, 2019
    Inventors: Andrew Lawrence FELDHAUS, Leon F. GARCIA-MARTINEZ, Benjamin H. DUTZAR, Ethan Wayne OJALA, Brian Robert KOVACEVICH, Katie Olson ANDERSON, Pei FAN, Jens BILLGREN, Erica Ann STEWART, Corinne C. AKATSUKA, Patricia Dianne MCNEILL, Danielle Marie MITCHELL, Dan Scott ALLISON, John A. LATHAM
  • Publication number: 20190381351
    Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The apparatus includes a frame, a first upper rear mounting point and a second lower front mounting point configured to maintain the frame, the first upper rear mounting point having an upper rear movable rotating joint, a seat connected to the frame and configured to support the user in a forward facing orientation, a wheel positioned in association with the frame, a set of pedals configured to interact with the wheel, a stem passing through the head tube, and a connection arrangement connecting the stem to a base. The frame is configured to pivot about the first upper rear mounting point and second lower front mounting point in response to leaning by the user, causing rotation of the stem by the connection arrangement.
    Type: Application
    Filed: August 29, 2019
    Publication date: December 19, 2019
    Inventors: Colin Irving, John J. Harrington, Brian C. Stewart, Michael S. Lofgren
  • Patent number: 10398934
    Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The apparatus includes a frame having a head tube, a first upper rear mounting point and a second lower front mounting point configured to maintain the frame, the first upper rear mounting point comprising an upper rear movable rotating joint, a seat connected to said frame and configured to support the user in a forward facing orientation, a wheel positioned in association with said frame, a set of pedals configured to interact with said wheel, and a stem connected to a handlebar arrangement, the stem passing through the head tube and connected to a base by a connection arrangement. The frame is configured to pivot about the first upper rear mounting point and second lower front mounting point in response to leaning by the user, causing rotation of the stem within the head tube.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: September 3, 2019
    Assignee: RealRyder, LLC
    Inventors: Colin Irving, John J. Harrington, Brian C. Stewart, Michael S. Lofgren
  • Patent number: 9669257
    Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The design includes a frame having a head tube, wherein the frame maintains a set of pedals, a first upper rear mounting point and a second lower front mounting point configured to maintain the frame, a seat connected to the frame configured to support the user, and a stem connected to a handlebar arrangement, passing through the head tube, and connected to a base by a connection arrangement. The frame is configured to pivot about the first upper rear mounting point and second lower front mounting point in response to leaning by the user causing movement of the connection arrangement and rotation of the stem. The connection arrangement is adjustable to vary amount of rotation of the stem within the head tube in response to leaning by the user.
    Type: Grant
    Filed: September 12, 2016
    Date of Patent: June 6, 2017
    Assignee: Real Ryder, LLC
    Inventors: Colin Irving, John J. Harrington, Brian C. Stewart, Michael S. Lofgren
  • Publication number: 20170001065
    Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The apparatus includes a frame having a head tube, a first upper rear mounting point and a second lower front mounting point configured to maintain the frame, the first upper rear mounting point comprising an upper rear movable rotating joint, a seat connected to said frame and configured to support the user in a forward facing orientation, a wheel positioned in association with said frame, a set of pedals configured to interact with said wheel, and a stem connected to a handlebar arrangement, the stem passing through the head tube and connected to a base by a connection arrangement. The frame is configured to pivot about the first upper rear mounting point and second lower front mounting point in response to leaning by the user, causing rotation of the stem within the head tube.
    Type: Application
    Filed: September 19, 2016
    Publication date: January 5, 2017
    Inventors: Colin Irving, John J. Harrington, Brian C. Stewart, Michael S. Lofgren
  • Publication number: 20160375299
    Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The design includes a frame having a head tube, wherein the frame maintains a set of pedals, a first upper rear mounting point and a second lower front mounting point configured to maintain the frame, a seat connected to the frame configured to support the user, and a stem connected to a handlebar arrangement, passing through the head tube, and connected to a base by a connection arrangement. The frame is configured to pivot about the first upper rear mounting point and second lower front mounting point in response to leaning by the user causing movement of the connection arrangement and rotation of the stem. The connection arrangement is adjustable to vary amount of rotation of the stem within the head tube in response to leaning by the user.
    Type: Application
    Filed: September 12, 2016
    Publication date: December 29, 2016
    Applicant: RealRyder, LLC
    Inventors: Colin Irving, John J. Harrington, Brian C. Stewart, Michael S. Lofgren
  • Patent number: 9440109
    Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The design includes a frame having a head tube, a first upper rear mounting point and a second lower front mounting point configured to maintain the frame, and a stem connected to a handlebar arrangement, the stem passing through the headset collar and connected to a base by a connection arrangement comprising an arm. The frame is configured to pivot about the first upper rear mounting point and second lower front mounting point in response to leaning by the user, causing rotation of the stem within the head tube by movement of the connection arrangement.
    Type: Grant
    Filed: November 24, 2014
    Date of Patent: September 13, 2016
    Assignee: RealRyder, LLC
    Inventors: Colin Irving, John J. Harrington, Brian C. Stewart, Michael S. Lofgren
  • Publication number: 20150080191
    Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The design includes a frame having a head tube, a first upper rear mounting point and a second lower front mounting point configured to maintain the frame, and a stem connected to a handlebar arrangement, the stem passing through the headset collar and connected to a base by a connection arrangement comprising an arm. The frame is configured to pivot about the first upper rear mounting point and second lower front mounting point in response to leaning by the user, causing rotation of the stem within the head tube by movement of the connection arrangement.
    Type: Application
    Filed: November 24, 2014
    Publication date: March 19, 2015
    Applicant: RealRyder, LLC
    Inventors: Colin Irving, John J. Harrington, Brian C. Stewart, Michael S. Lofgren
  • Patent number: 8894550
    Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The design includes a frame having a head tube, a first upper rear mounting point and a second lower front mounting point configured to maintain the frame, a seat connected to said frame and configured to support the user in a forward facing orientation, a wheel positioned in association with said frame and pedals configured to interact with said wheel, and a stem connected to a handlebar arrangement, the stem passing through the headset collar and connected to a base by a connection arrangement comprising an arm. The frame is configured to pivot about the first upper rear mounting point and second lower front mounting point in response to leaning by the user, causing rotation of the stem within the head tube by movement of the connection arrangement comprising the arm.
    Type: Grant
    Filed: February 11, 2013
    Date of Patent: November 25, 2014
    Assignee: RealRyder, LLC
    Inventors: Colin Irving, John J. Harrington, Brian C. Stewart, Michael S. Lofgren
  • Publication number: 20130157813
    Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The design includes a frame having a head tube, a first upper rear mounting point and a second lower front mounting point configured to maintain the frame, a seat connected to said frame and configured to support the user in a forward facing orientation, a wheel positioned in association with said frame and pedals configured to interact with said wheel, and a stem connected to a handlebar arrangement, the stem passing through the headset collar and connected to a base by a connection arrangement comprising an arm. The frame is configured to pivot about the first upper rear mounting point and second lower front mounting point in response to leaning by the user, causing rotation of the stem within the head tube by movement of the connection arrangement comprising the arm.
    Type: Application
    Filed: February 11, 2013
    Publication date: June 20, 2013
    Applicant: RealRyder, LLC
    Inventors: Colin Irving, John J. Harrington, Brian C. Stewart, Michael S. Lofgren
  • Patent number: 8371992
    Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The design includes a frame and a first mounting point and a second mounting point configured to maintain the frame. A seat is connected to the frame and configured to support the user. A wheel is positioned in association with said frame and pedals configured to interact with the wheel, and the frame is configured to pivot about the first mounting point and second mounting point in response to leaning by the user. Handlebars may be provided that enable further force application and enhance the leaning or pivoting in the bicycle riding simulation experience.
    Type: Grant
    Filed: April 15, 2011
    Date of Patent: February 12, 2013
    Assignee: RealRyder, LLC
    Inventors: Colin Irving, John J. Harrington, Brian C. Stewart, Michael S. Lofgren
  • Publication number: 20110195820
    Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The design includes a frame and a first mounting point and a second mounting point configured to maintain the frame. A seat is connected to the frame and configured to support the user. A wheel is positioned in association with said frame and pedals configured to interact with the wheel, and the frame is configured to pivot about the first mounting point and second mounting point in response to leaning by the user. Handlebars may be provided that enable further force application and enhance the leaning or pivoting in the bicycle riding simulation experience.
    Type: Application
    Filed: April 15, 2011
    Publication date: August 11, 2011
    Applicant: RealRyder, LLC.
    Inventors: Colin Irving, John J. Harrington, Brian C. Stewart, Michael S. Lofgren
  • Patent number: 7927258
    Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The design includes a frame and a first mounting point and a second mounting point configured to maintain the frame. A seat is connected to the frame and configured to support the user. A wheel is positioned in association with said frame and pedals configured to interact with the wheel, and the frame is configured to pivot about the first mounting point and second mounting point in response to leaning by the user. Handlebars may be provided that enable further force application and enhance the leaning or pivoting in the bicycle riding simulation experience.
    Type: Grant
    Filed: August 17, 2007
    Date of Patent: April 19, 2011
    Assignee: Real Ryder, LLC
    Inventors: Colin Irving, John J. Harrington, Brian C. Stewart, Michael S. Lofgren
  • Publication number: 20090048076
    Abstract: An apparatus permitting a user to perform a simulated bicycling exercise is provided. The design includes a frame and a first mounting point and a second mounting point configured to maintain the frame. A seat is connected to the frame and configured to support the user. A wheel is positioned in association with said frame and pedals configured to interact with the wheel, and the frame is configured to pivot about the first mounting point and second mounting point in response to leaning by the user. Handlebars may be provided that enable further force application and enhance the leaning or pivoting in the bicycle riding simulation experience.
    Type: Application
    Filed: August 17, 2007
    Publication date: February 19, 2009
    Inventors: Colin Irving, John J. Harrington, Brian C. Stewart, Michael S. Lofgren
  • Patent number: 5853184
    Abstract: A hand-powered vehicle with a device for positioning the crank arms so that the rider can easily adjust them for both vertical and horizontal movement and placement. A device for supporting the rider's legs and feet that combines both a leg support and footrest that can be adjusted forward and rearward relative to the front wheel to accommodate different rider leg lengths. A device for triangulating the frame behind the seat in order to increase frame rigidity between the crank arms and the seat back. A self tightening seat with fabric attached in such a manner that the rider's weight holds the seat frame attached to the frame of the cycle. A device for quickly removing and replacing the rear axle while maintaining proper toe in and toe out of the rear wheels. A device for lowering the structure of the frame below the axis of the front wheel for the purpose of lowering the center of gravity of the bike and rider.
    Type: Grant
    Filed: February 23, 1996
    Date of Patent: December 29, 1998
    Inventors: Michael S. Lofgren, Brian C. Stewart
  • Patent number: 4789173
    Abstract: A three-wheel vehicle having front and rear frame sections supporting a single front wheel and a pair of rear wheels respectively. The frame sections are pivotally interconnected about an inclined axis defined by a front lower and rear upper pivotal connection. The upper pivotal connection is provided on a swivel bar which is pivotally connected to the rear frame section for swivel pivoting of the pivotal connection defining the inclined axis. A seat on the front frame section positioned substantially above the swiveled pivotal connection is shifted from side-to-side with the pivoting of the swivel bar and inclined axis. A handle from the swivel bar enables a rider to control the swivel bar for shifting of the rider's weight and increased or decreased articulation of the vehicle frame and thus turning of the vehicle to thereby increase or decrease the turning that is induced by pivoting of the front frame section about the inclined axis.
    Type: Grant
    Filed: December 15, 1987
    Date of Patent: December 6, 1988
    Inventors: Michael S. Lofgren, Brian C. Stewart
  • Patent number: 4572535
    Abstract: A three-wheeled vehicle having a front body member carrying the front wheel and seat, pivotally connected to a rear body member carrying the rear wheels and handlebar. The pivotal connection is designed to pivot the front body member around a pivotal axis that is projected upwardly and rearwardly at a location rearward of the front wheel whereby pivoting produces sideward and rearward tilting of the front wheel and opposite turning of the rear wheels. Steering is achieved by such pivoting of the front body member which in turn is achieved by a sideward swinging of the seat that is positioned between the two pivotal connections. The rear wheels are preferably canted to provide increased stability for the vehicle as it is maneuvered through a turn.
    Type: Grant
    Filed: November 16, 1984
    Date of Patent: February 25, 1986
    Inventors: Brian C. Stewart, Michael S. Lofgren