Abstract: The present invention uses spectroscopic tissue volume measurements using non-ionizing radiation to detect pre-disease transformations in the tissue, which increase the risk for this disease in mammals. The method comprises illuminating a volume of selected tissue of a mammal with light having wavelengths covering a pre-selected spectral range, detecting light transmitted through, or reflected from, the volume of selected tissue, and obtaining a spectrum of the detected light. The spectrum of detected light is then represented by one or more basis spectral components, an error term, and an associated scalar coefficient for each of the basis spectral components. The associated scalar coefficient is calculated by minimizing the error term.

Abstract: A task-based multi-process design synthesis methodology relies on a plurality of child processes to assist a parent process in performing optimizations on an integrated circuit design. Objects from an integrated circuit design are grouped into subsets and assigned to child processes, with each child process performing a transform on each of the objects in the subset assigned to that child process and determining which of the objects in the subset are candidate objects for which performance of the transform has been successful. The child processes then notify the parent process of those objects that qualify as candidate objects, so that the parent process only has to perform the transform on the candidate objects, thereby relieving the parent process from the overhead associated with performing the transform on non-candidate objects for which the transform has been determined by the child processes as not being successful.

Abstract: A device for fluorescence-based imaging and monitoring of a target comprising: a light source emitting light for illuminating the target, the emitted light including at least one wavelength or wavelength band causing at least one biomarker associated with the target to fluoresce; and a light detector for detecting the fluorescence.

Abstract: Photodynamic therapy (PDT) is used in the case of bone. A photosensitizing drug is administered to a mammal. A bone insertion member is secured into bone. A fiber optic cable sheath extends from within the bone insertion member and is accessible. A fiber optic cable is inserted in the fiber optic cable sheath to deliver light to the bone. A locking member is then attached to the insertion member. Non-thermal light at a specific wavelength is then delivered to activate the drug. The insertion member and the fiber optic cable sheath may remain inside the mammal for further photodynamic therapy.

Abstract: A method is described for computing a statistically significant difference between dysplasia and Barrett's esophagus (both with and without inflammatory component) using a discriminate function with diffuse reflectance measurements performed at a minimum of four different wavelengths of 485, 513, 598, and 629 nm. The discriminate function found depends both on local blood fraction volume THB and oxygenation SO2. A pull-back approach of spectral data acquisition is disclosed which takes into account tissue motility in esophagus and measurement geometry peculiarities. The pull-back approach provides a significant improvement of measurement reproducibility and reduction of data deviation by 75-100%, resulting in a better discrimination between different histological groups.

Abstract: A method, system and program product are described for implementing an integrated circuit. Synthesis tools and a continuum of physical constraints are used to generate a physical realization of a circuit from a hierarchy of logical circuits. Missing physical constraints are generated based on the behavior of the logical circuits, technology rules, timing constraints, and user controls. These constraints are refined throughout the process to produce an accurate physical realization. Generation of the physical constraints is user-controlled, allowing for a full continuum of input.

Abstract: In a first aspect, a first method of designing a circuit is provided. The first method includes the steps of (1) providing a model of an original circuit design including a latch; (2) providing a model of a modified version of the original circuit design, wherein the modified version of the original circuit design includes a set of latches associated with the latch of the original circuit design and voting logic having inputs coupled to respective outputs of latches in the latch set; and (3) during Boolean equivalency checking (BEC), injecting an error on at most a largest minority of the inputs of the voting logic to test the voting logic function.

Abstract: In a first aspect, a first method of designing a circuit is provided. The first method includes the steps of (1) providing a model of an original circuit design including a latch; (2) providing a model of a modified version of the original circuit design, wherein the modified version of the original circuit design includes a set of latches associated with the latch of the original circuit design and voting logic having inputs coupled to respective outputs of latches in the latch set; and (3) during Boolean equivalency checking (BEC), injecting an error on at most a largest minority of the inputs of the voting logic to test the voting logic function.

Abstract: A method and an apparatus for examining the sub-surface microstructure of a sample are provided. Radiation from a plurality of optical radiation sources travels along a first optical path. In the first optical path, a device focuses the optical radiation from each of the optical sources into a plurality of respective focal points along the first optical path to provide substantially continuous coverage of a selected portion of the first optical path. Then, a sample on the first optical path within the selected length extending into the sample is scanned along said selected portion of the first optical path.

Abstract: Multiple site information of light intensity is obtained by application of a multiple-fibre probe in a real-time optical monitoring system. The multiple-fibre probe includes a plurality of optical fibres distributed along the length of the probe. Each optical fibre may be is switchable between the mode for transmitting optical signal into the malignant tissue and the mode for collecting the optical signal from the same tissue. Thus the numbers of the probes can be minimized for collecting multiple site light information and the irritation to the tissue is reduced. A method of using such a probe to determine coagulated boundary in thermal or other treatment is also described.

Abstract: In a first aspect, a first method of designing a circuit is provided. The first method includes the steps of (1) providing a model of an original circuit design including a latch; (2) providing a model of a modified version of the original circuit design, wherein the modified version of the original circuit design includes a set of latches associated with the latch of the original circuit design and voting logic having inputs coupled to respective outputs of latches in the latch set; and (3) during Boolean equivalency checking (BEC), injecting an error on at most a largest minority of the inputs of the voting logic to test the voting logic function.

Abstract: A method and an apparatus for examining the subsurface microstructure of a sample are provided. Radiation from a plurality of optical radiation sources travels along a first optical path. In the first optical path, a device focuses the optical radiati n from each of the optical sources into a plurality of respective focal points along the first optical path to provide substantially continuous coverage of a selected portion of the first optical path. Then, a sample on the first optical path within the selected length extending into the sample is scanned along said selected portion of the first optical path.

Abstract: A method and an apparatus for examining the subsurface microstructure of a sample are provided. Radiation from a plurality of ptical radiation sources travels along a first ptical path. In the first optical path, a device focuses the optical radiati n from each of the optical sources into a plurality of respective focal points along the first optical path to provide substantially continuous coverage of a selected portion of the first optical path. Then, a sample on the first optical path within the selected length extending into the sample is scanned along said selected portion of the first optical path.

Abstract: The present invention provides a multi-spectral optical, open-field detection system utilizing light-induced-fluorescence imaging and point spectroscopy for use in in-situ diagnosis and treatment of diseased tissue with reduced sensitivity to changes in light source-target-detector geometry. The light excitation and detection optics share a common coaxial optical path which makes the present system very robust to changes in illumination-target-detector geometry. The apparatus may be used for the detection and localization of tumors or other pathological tissues both prior to treatment and for the detection of residual diseases during or after surgery or other treatments to remove or destroy the diseased tissue.

Abstract: The invention features a probe for radiance dosimetry. The probe includes a tip portion containing a fluorescent dye connected to a translucent spacer element.