Patents by Inventor Brian Cain
Brian Cain has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250050340Abstract: A microfluidic device for modeling a tumor-immune microenvironment can include a multiwell plate defining a plurality of microenvironment units fluidically coupled with a plurality of wells. Each microenvironment unit of the plurality of microenvironment units can include one or more compartments. Each microenvironment unit can include a trapping feature positioned within the one or more compartments. The trapping feature can be defined by a portion of at least one of a sidewall or a floor of the one or more compartments. The trapping feature can restrict movement of a tissue sample introduced into the one or more compartments and to allow fluid to flow past the tissue sample. The microfluidic device can include a plurality of micropumps each coupled with a respective well and configured to control movement of a respective fluid sample through each respective well.Type: ApplicationFiled: October 29, 2024Publication date: February 13, 2025Applicant: The Charles Stark Draper Laboratory Inc.Inventors: Jeffrey Borenstein, Nathan Moore, Daniel Doty, Timothy Haggerty, Joseph Charest, Alla Gimbel, Vienna Mott, Brett Isenberg, Hesham Azizgolshani, Brian Cain, Mark Mescher
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Patent number: 12201802Abstract: A multi-fluid injector system having a powered injector having a housing enclosing at least one reciprocally operable piston is described. The injector system includes a multi-use disposable set (MUDS) connectable to the powered fluid injector. The MUDS has at least one syringe having a proximal end and a distal end and a plunger reciprocally movable by the at least one piston element within a syringe interior between the proximal end and the distal end; a manifold in fluid communication with the distal end of the at least one syringe; at least one valve in fluid communication with the syringe interior, the at least one valve operable between a filling position for filling the syringe interior with fluid and a delivery position for delivering the fluid from the syringe interior; and at least one connection port in fluid communication with the manifold and the syringe interior when the at least one valve is in the delivery position.Type: GrantFiled: November 2, 2022Date of Patent: January 21, 2025Assignee: BAYER HEALTHCARE LLCInventors: John Haury, Michael Swantner, Richard Sokolov, Benjamin James Cullen, Alison Ruth Von Moger, Ernesto Hueso Monis, Kamman Law, Mark Silivio Profaca, Patrick Spence, Michael Spohn, Justin Angert, Brian Cain
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Patent number: 11999084Abstract: A syringe includes a barrel having a proximal end, a distal end, and a sidewall extending substantially circumferentially between the proximal end and the distal end along a longitudinal axis. The barrel is formed from an injection molding process including aligning a mold die defining an internal shape of the barrel in a molding cavity defining an external shape of the barrel, the molding cavity defined by first and second mold sections. Each mold section includes at least one gate adapted to control the flow of a molding material into the molding cavity. The gates of each mold section are opened to permit the first and second melt streams of molding material to fill the molding cavity surrounding the mold die, where the molding material takes the shape of the molding cavity.Type: GrantFiled: September 25, 2017Date of Patent: June 4, 2024Assignee: BAYER HEALTHCARE LLCInventors: Brian Cain, Matthew Schrauder, Theodore B. Lemke, Randy J. Krell
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Patent number: 11865294Abstract: A fluid control valve for use in a fluid delivery system for delivering fluid to a patient includes a valve body defining an internal chamber, a first inlet port for receiving a first inlet tube, a second inlet port for receiving a second inlet tube, an outlet port, and a sliding valve member slidably disposed in the internal chamber. The first inlet tube defines a first inlet lumen axially aligned with the internal chamber. The second inlet tube defines a second inlet lumen axially aligned with the internal chamber. The sliding valve member includes a first sealing end and second sealing end. The sliding valve member is positionable in a first operating state, a second operating state, and a third operating state based on a flow differential between the first inlet lumen and the second inlet lumen.Type: GrantFiled: October 16, 2017Date of Patent: January 9, 2024Assignee: BAYER HEALTHCARE LLCInventors: Michael Spohn, Kevin Cowan, Brian Cain, David Berry, James Fentress, David Orenstein, James Dedig, Barry Tucker
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Patent number: 11760967Abstract: This disclosure provides systems and methods for seeding cell cultures in a microfluidic device. The systems and methods of this disclosure can enable flow of a cell solution from one side of a scaffold, such as a porous substrate or membrane, to the other side of the scaffold. Flow of the liquid can pass through the scaffold while the cells themselves do not, resulting in the cells driven to the surface of the scaffold for consequent attachment. A microfluidic device can include a microfluidic feature structured to create a seal between a cell seeding tool and an inlet to a microchannel of the microfluidic device. This can enable a pressure-driven flow to push fluid down the channel and through pores of the membrane. In contrast, traditional gravity fed seeding of cells may not create enough pressure to drive fluid through the pores of the scaffold.Type: GrantFiled: September 4, 2020Date of Patent: September 19, 2023Assignee: Charles Stark Draper Laboratory, Inc.Inventors: Hesham Azizgolshani, Brian Cain, Joseph Charest, Jonathan Robert Coppeta, Brett Isenberg, Timothy Petrie
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Publication number: 20230166095Abstract: A multi-fluid injector system having a powered injector having a housing enclosing at least one reciprocally operable piston is described. The injector system includes a multi-use disposable set (MUDS) connectable to the powered fluid injector. The MUDS has at least one syringe having a proximal end and a distal end and a plunger reciprocally movable by the at least one piston element within a syringe interior between the proximal end and the distal end; a manifold in fluid communication with the distal end of the at least one syringe; at least one valve in fluid communication with the syringe interior, the at least one valve operable between a filling position for filling the syringe interior with fluid and a delivery position for delivering the fluid from the syringe interior; and at least one connection port in fluid communication with the manifold and the syringe interior when the at least one valve is in the delivery position.Type: ApplicationFiled: November 2, 2022Publication date: June 1, 2023Inventors: JOHN HAURY, MICHAEL SWANTNER, RICHARD SOKOLOV, BENJAMIN JAMES CULLEN, ALISON RUTH VON MOGER, ERNESTO HUESO MONIS, KAMMAN LAW, MARK SILIVIO PROFACA, PATRICK SPENCE, MICHAEL SPOHN, JUSTIN ANGERT, BRIAN CAIN
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Patent number: 11491318Abstract: A multi-use disposable set (MUDS) has at least one syringe having a proximal end and a distal end spaced apart from the proximal end along a longitudinal axis. The MUDS further has a plunger reciprocally movable within a syringe interior between the proximal end and the distal end. A manifold is in fluid communication with the distal end of the at least one syringe. At least one valve is in fluid communication with the syringe interior. The at least one valve is operable between a filling position for filling the syringe interior with fluid and a delivery position for delivering the fluid from the syringe interior. At least one connection port is in fluid communication with the manifold and the syringe interior when the at least one valve is in the delivery position. A multi-fluid delivery system having the medical connector and MUDS is also provided. Various features of the MUDS system are also described.Type: GrantFiled: December 13, 2019Date of Patent: November 8, 2022Assignee: BAYER HEALTHCARE LLCInventors: John Haury, Michael Swantner, Richard Sokolov, Benjamin James Cullen, Alison Ruth Von Moger, Ernesto Hueso Monis, Kamman Law, Mark Silivio Profaca, Patrick Spence, Michael Spohn, Justin Angert, Brian Cain
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Patent number: 11083882Abstract: A connector assembly may include a body and a fluid fitting, the fluid fitting configured for releasably engaging a syringe nozzle, at least one deflectable locking arm connected to the body and radially deflectable relative to the distal end, the proximal end of the at least one deflectable locking arm configured for deflecting in a radial direction relative to the distal end to releasably engage the syringe nozzle, and at least one locking element disposed on the at least one deflectable locking arm, the at least one locking element movable with movement of the at least one deflectable locking arm between a first position where the at least one locking element is released from an engagement portion of the syringe nozzle and a second position where the at least one locking element is engaged with the engagement portion of the syringe nozzle.Type: GrantFiled: November 23, 2016Date of Patent: August 10, 2021Assignee: BAYER HEALTHCARE LLCInventors: Matthew Schrauder, Brian Cain, Michael Cousley, Kevin Cowan, Michael Spohn
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Publication number: 20210162416Abstract: A microfluidic device for modeling a tumor-immune microenvironment can include a multiwell plate defining a plurality of microenvironment units fluidically coupled with a plurality of wells. Each microenvironment unit of the plurality of microenvironment units can include one or more compartments. Each microenvironment unit can include a trapping feature positioned within the one or more compartments. The trapping feature can be defined by a portion of at least one of a sidewall or a floor of the one or more compartments. The trapping feature can restrict movement of a tissue sample introduced into the one or more compartments and to allow fluid to flow past the tissue sample. The microfluidic device can include a plurality of micropumps each coupled with a respective well and configured to control movement of a respective fluid sample through each respective well.Type: ApplicationFiled: December 1, 2020Publication date: June 3, 2021Inventors: Jeffrey Borenstein, Nathan Moore, Daniel Doty, Timothy Haggerty, Joseph Charest, Alla Gimbel, Vienna Mott, Brett Isenberg, Hesham Azizgolshani, Brian Cain, Mark Mescher
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Publication number: 20210071125Abstract: This disclosure provides systems and methods for seeding cell cultures in a microfluidic device. The systems and methods of this disclosure can enable flow of a cell solution from one side of a scaffold, such as a porous substrate or membrane, to the other side of the scaffold. Flow of the liquid can pass through the scaffold while the cells themselves do not, resulting in the cells driven to the surface of the scaffold for consequent attachment. A microfluidic device can include a microfluidic feature structured to create a seal between a cell seeding tool and an inlet to a microchannel of the microfluidic device. This can enable a pressure-driven flow to push fluid down the channel and through pores of the membrane. In contrast, traditional gravity fed seeding of cells may not create enough pressure to drive fluid through the pores of the scaffold.Type: ApplicationFiled: September 4, 2020Publication date: March 11, 2021Inventors: Hesham Azizgolshani, Brian Cain, Joseph Charest, Jonathan Robert Coppeta, Brett Isenberg, Timothy Petrie
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Publication number: 20200114138Abstract: A multi-use disposable set (MUDS) has at least one syringe having a proximal end and a distal end spaced apart from the proximal end along a longitudinal axis. The MUDS further has a plunger reciprocally movable within a syringe interior between the proximal end and the distal end. A manifold is in fluid communication with the distal end of the at least one syringe. At least one valve is in fluid communication with the syringe interior. The at least one valve is operable between a filling position for filling the syringe interior with fluid and a delivery position for delivering the fluid from the syringe interior. At least one connection port is in fluid communication with the manifold and the syringe interior when the at least one valve is in the delivery position. A multi-fluid delivery system having the medical connector and MUDS is also provided. Various features of the MUDS system are also described.Type: ApplicationFiled: December 13, 2019Publication date: April 16, 2020Inventors: JOHN HAURY, MICHAEL SWANTNER, RICHARD SOKOLOV, BENJAMIN JAMES CULLEN, ALISON RUTH VON MOGER, ERNESTO HUESO MONIS, KAMMAN LAW, MARK SILIVIO PROFACA, PATRICK SPENCE, MICHAEL SPOHN, JUSTIN ANGERT, BRIAN CAIN
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Publication number: 20200094454Abstract: A syringe includes a barrel having a proximal end, a distal end, and a sidewall extending substantially circumferentially between the proximal end and the distal end along a longitudinal axis. The barrel is formed from an injection molding process including aligning a mold die defining an internal shape of the barrel in a molding cavity defining an external shape of the barrel, the molding cavity defined by first and second mold sections. Each mold section includes at least one gate adapted to control the flow of a molding material into the molding cavity. The gates of each mold section are opened to permit the first and second melt streams of molding material to fill the molding cavity surrounding the mold die, where the molding material takes the shape of the molding cavity.Type: ApplicationFiled: September 25, 2017Publication date: March 26, 2020Inventors: Brian Cain, Matthew Schrauder, Theodore B. Lemke, Randy J. Krell
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Publication number: 20190232041Abstract: A fluid control valve for use in a fluid delivery system for delivering fluid to a patient includes a valve body defining an internal chamber, a first inlet port for receiving a first inlet tube, a second inlet port for receiving a second inlet tube, an outlet port, and a sliding valve member slidably disposed in the internal chamber. The first inlet tube defines a first inlet lumen axially aligned with the internal chamber. The second inlet tube defines a second inlet lumen axially aligned with the internal chamber. The sliding valve member includes a first sealing end and second sealing end. The sliding valve member is positionable in a first operating state, a second operating state, and a third operating state based on a flow differential between the first inlet lumen and the second inlet lumen.Type: ApplicationFiled: October 16, 2017Publication date: August 1, 2019Inventors: MICHAEL SPOHN, KEVIN COWAN, Brian CAIN, David Berry, James Fentress, David Orenstein, James DEDIG, Barry TUCKER
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Publication number: 20180339146Abstract: A connector assembly may include a body and a fluid fitting, the fluid fitting configured for releasably engaging a syringe nozzle, at least one deflectable locking arm connected to the body and radially deflectable relative to the distal end, the proximal end of the at least one deflectable locking arm configured for deflecting in a radial direction relative to the distal end to releasably engage the syringe nozzle, and at least one locking element disposed on the at least one deflectable locking arm, the at least one locking element movable with movement of the at least one deflectable locking arm between a first position where the at least one locking element is released from an engagement portion of the syringe nozzle and a second position where the at least one locking element is engaged with the engagement portion of the syringe nozzle.Type: ApplicationFiled: November 23, 2016Publication date: November 29, 2018Inventors: MATTHEW SCHRAUDER, BRIAN CAIN, MICHAEL COUSLEY, KEVIN COWAN, MICHAEL SPOHN, TIMOTHY PARMER, JUSTIN BECHSTEIN, RYAN POLCIN, SAM JANG, DAVE HEGGERNES, PATRICIA SANDEKIAN, JACK POLLITT, JEREMY ODEGARD, DAVID WOLGEMUTH
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Patent number: 8720445Abstract: Tracheal tubes having an integrated calorimetric CO2 indicator are provided. In certain embodiment, the integrated CO2 indicator is selectively sealed from the remainder of the tracheal tube by a removable sterilization barrier. Also provided are CO2 indicators that exhibit long lasting, breath-to-breath dynamic color change and are storage stable. The devices and compositions of the invention find use in a variety of applications, e.g. in emergent intubation of a subject. Also provided are methods of making the devices and compositions, as well as kits that include the devices and/or compositions of the invention.Type: GrantFiled: June 13, 2008Date of Patent: May 13, 2014Assignee: Affirm Medical Technologies, LLCInventors: Brian Cain, Janice Cain, Fred Johnson, Steve Woodard, Stephen Lee, Sherry Zhang
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Publication number: 20090095290Abstract: Tracheal tubes having an integrated calorimetric CO2 indicator are provided. In certain embodiment, the integrated CO2 indicator is selectively sealed from the remainder of the tracheal tube by a removable sterilization barrier. Also provided are CO2 indicators that exhibit long lasting, breath-to-breath dynamic color change and are storage stable. The devices and compositions of the invention find use in a variety of applications, e.g. in emergent intubation of a subject. Also provided are methods of making the devices and compositions, as well as kits that include the devices and/or compositions of the invention.Type: ApplicationFiled: June 13, 2008Publication date: April 16, 2009Inventors: Brian Cain, Janice Cain, Fred Johnson, Steve Woodard, Stephen Lee, Sherry Zhang
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Publication number: 20030080143Abstract: A method for depositing a volume of fluid relative to a surface to produce a droplet relative to the surface comprising the steps of forming a bolus of liquid relative to a dispensing member, causing the bolus of liquid to make contact with a surface thereby forming a bridge of liquid between the dispensing member and the surface, and retracting only a portion of the bolus of liquid to break the bridge of liquid between the dispensing member and the surface thereby depositing a droplet on the surface. A volume of a droplet can be adjusted by forming a bridge of liquid between a dispensing member and a surface that includes an initial droplet and breaking the bridge of liquid while leaving a remaining droplet of a different volume than the initial droplet.Type: ApplicationFiled: April 4, 2002Publication date: May 1, 2003Applicant: Arradial, Inc.Inventors: Samesh Kale, George Seward, Namyong Kim, Brian Cain, Timothy Moulton, Michael Septak, Charles Burke, Douglas Bourn