Abstract: Designed polypeptides that bind specifically to a defined protein target are provided, as well as methods for their design and use.

Abstract: Described herein, inter alia, are MRGPRX2 antagonists and uses thereof.

Abstract: The disclosure provides at least one entity chosen from compounds of Formula (I) pharmaceutically acceptable salts thereof, solvates of any of the foregoing, and deuterated derivatives of any of the foregoing, compositions comprising the same, and methods of using the same, including use in treating APOL1 mediated kidney disease.

Abstract: Processing facilities, systems, devices, equipment, and associated methods of processing for recycling thermosetting polymers are described herein. In one example, a process includes reacting, under atmospheric pressure, a thermosetting polymer with a catalytic solution containing a solvent having sulfolane and/or a derivative thereof. The reaction converts the thermosetting polymer to polymer fragments dissolvable in the sulfolane and/or the derivative thereof of the catalytic solution. The process then includes causing the polymer fragments to precipitate as solid polymer fragments from the catalytic solution and separating the precipitated polymer fragments from the catalytic solution. As such, the thermosetting polymer can be recycled as the solid polymer fragments.

Abstract: The present technology has the ability to establish connections between content that do not have direct or explicit relationships. Implicit influence relationships can be established from user download sequence data, campaign data with keyword targeting, and content review data that mentions other content. Using these influence relationships, the relevance of content items can be determined based on the influence relationship of linked content items and a similarity relationship of content items. However, the importance of the influence relationship in ranking content items can vary depending on the parameters against which the content item is considered relevant. To address this, the present technology includes a context-driven factor that is used as a weight to adjust the impact of the influence relationship of the ranking, depending on the parameters against which the content item is considered relevant.

Abstract: The disclosure provides at least one entity chosen from compounds of formula (I), solid state forms of the same, compositions comprising the same, and methods of using the same, including use in treating focal segmental glomerulosclerosis (FSGS) and/or non-diabetic kidney disease (NDKD).

Abstract: Designed is a system and method for providing line of sight interaction in an AR environment between users of portable devices with the camera. The system and method uses computer-generated images to represent other system users and real or fictional objects with the precise location in 3 dimensional space. This Digital scene is overlaid onto and combined with the current real world environment as seen on the users' viewfinder. The invention is a novel system and method for allowing users to aim their portable devices and interact or communicate with the CGI images or other users of the same system, creating an augmented reality experience that is enhanced by a line of sight style communication.

Abstract: A billiard type game system for playing a billiard type game on a game table. The game table has a table top which is defined by rails, consecutively numbered vertical pockets extending through the table top, a corresponding bumper for each pocket, and sets of color coded numbered balls. The pockets are scattered around the table top and are located away from the rails. Each pocket has a bumper positioned adjacent to the pocket, and an indicator also positioned adjacent to each pocket. The indicators serve as starting points from which the balls are hit across the table top towards the next consecutively numbered appropriate pocket. The object of the game is to the sink each of the balls of a player into the appropriate pockets according to a specified order.