Patents by Inventor Brian Chait
Brian Chait has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220367163Abstract: A parallel multi-beam mass spectrometer includes an ion trap and a single multi-beam time-of-flight analyzer. The trap has a plurality of alternating electrodes configured to form a plurality of quadrupoles defining a surface of the trap, wherein at least two of the plurality of quadrupoles are configured as mass filters for selective ejection of concurrent parallel beams of ions from the trap in respective predetermined ion mass-to-charge windows. The single multi-beam time-of-flight analyzer has a position sensitive detector or a plurality of individual detectors for simultaneously receiving and analyzing the concurrent parallel beams of ions.Type: ApplicationFiled: May 24, 2022Publication date: November 17, 2022Inventors: Andrew Krutchinsky, Brian Chait
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Publication number: 20210233753Abstract: A parallel multi-beam mass spectrometer includes an ion trap and a single multi-beam time-of-flight analyzer. The trap has a plurality of alternating electrodes configured to form a plurality of quadrupoles defining a surface of the trap, wherein at least two of the plurality of quadrupoles are configured as mass filters for selective ejection of concurrent parallel beams of ions from the trap in respective predetermined ion mass-to-charge windows. The single multi-beam time-of-flight analyzer has a position sensitive detector or a plurality of individual detectors for simultaneously receiving and analyzing the concurrent parallel beams of ions.Type: ApplicationFiled: June 5, 2019Publication date: July 29, 2021Inventors: Andrew Krutchinsky, Brian Chait
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Patent number: 9610319Abstract: A method of treating liver cancer using a peptide based on venom from a terebrid snail, terebrid variegata, is described. The venom has a general formula of TRX3CCGCYWNGSKDVCSQSCC (SEQ ID NO: 1) and variants thereof are described.Type: GrantFiled: September 30, 2015Date of Patent: April 4, 2017Assignees: Research Foundation of the City University of New York, The Rockefeller UniversityInventors: Mande Holford, Prachi Anand, Beatrix Ueberheide, Brian Chait
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Publication number: 20160089416Abstract: This disclosure pertains to a method of treating liver cancer using a peptide based on venom from a terebrid snail, terebrid variegata. The venom has a general formula of TRX3CCGCYWNGSKDVCSQSCC (SEQ ID NO. 1) and variants thereof are described.Type: ApplicationFiled: September 30, 2015Publication date: March 31, 2016Inventors: Mande Holford, Prachi Anand, Beatrix Ueberheide, Brian Chait
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Publication number: 20070077600Abstract: The present invention is method of determining whether or not associations between a given protein and other proteins in a cell are specific.Type: ApplicationFiled: August 21, 2006Publication date: April 5, 2007Inventors: Brian Chait, Alan Tackett, Jeffrey DeGrasse, Marlene Oeffinger, Michael Rout, Matthew Sekedat
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Publication number: 20070045533Abstract: A method for manipulating ions in an ion trap includes storing ions, spatially compressing, and ejecting selected ions according to mass-to-charge ratio. An ion trap includes an injection port, an arm having a first and a second end for confining and spatially compressing the ions, and an ejection port for ejecting the ions from the second end. The arm includes two pairs of opposing electrodes, which provide a quadrupole electric field potential at any cross-section of the ion trap. The distance between opposing electrodes and the cross-sectional area of the electrodes increases from the first to second end. The electrodes may be tapered cylindrical rods or of hyperbolic cross-section. Ions selected for ejection are spatially compressed into a region at the second (wider) end. The ion trap may include one arm, with either orthogonal or axial ejection, or two arms with a central insert for orthogonal ejection.Type: ApplicationFiled: August 31, 2005Publication date: March 1, 2007Inventors: Andrew Krutchinsky, Herbert Cohen, Brian Chait
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Patent number: 7109479Abstract: A system for determining the ratio of mass to charge of an ion including a pulsed ionizer, a high pressure co-linear ion guide/accelerator, and a mass analyzer. The pulsed ionizer generates intact analyte ions from a sample of matter to be analyzed. The high pressure co-linear ion guide/accelerator is interfaced with the ion source for receipt of the intact ions of the sample. The ion guide/accelerator simultaneously dampens and linearly accelerates the intact ions in the substantial absence of fragmentation of the ions to provide a substantially continuous beam of the intact ions for mass analysis. The mass analyzer is connected to the ion guide/accelerator for receipt of the beam of ions and determines the mass to charge ratio of the intact ions.Type: GrantFiled: September 28, 2004Date of Patent: September 19, 2006Assignee: The Rockefeller UniversityInventors: Andrew Krutchinsky, Herbert Cohen, Markus Kalkum, Vadim Sherman, Brian Chait
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Patent number: 7012249Abstract: Disclosed is an apparatus for examining and inspecting at least one sample in order to determine characteristics of the sample having the a support for receiving a compact disc, the compact disc having deposited on a surface thereof at least one sample, inspection means for effecting a physical change in at least one sample, the inspection means positioned for registration with the surface of the compact disc bearing at least one sample; and a traversal mechanism adapted for reciprocating movement, to move the sample in and out of the path of the inspection means.Type: GrantFiled: August 23, 2004Date of Patent: March 14, 2006Assignee: The Rockefeller UniversityInventors: Andrew Krutchinsky, Brian Chait
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Publication number: 20050153454Abstract: Method is described for sequencing polypeptides by forming peptide ladders comprising a series of polypeptides in which adjacent members of the series vary by one amino acid residue and determining the identity and position of each amino acid in the polypeptide by mass spectroscopy.Type: ApplicationFiled: December 1, 2004Publication date: July 14, 2005Applicants: The Rockefeller University, The Scripps Research InstituteInventors: Brian Chait, Ronald Beavis, Rong Wang, Stephen Kent
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Publication number: 20050092912Abstract: A system for determining the ratio of mass to charge of an ion including a pulsed ionizer, a high pressure co-linear ion guide/accelerator, and a mass analyzer. The pulsed ionizer generates intact analyte ions from a sample of matter to be analyzed. The high pressure co-linear ion guide/accelerator is interfaced with the ion source for receipt of the intact ions of the sample. The ion guide/accelerator simultaneously dampens and linearly accelerates the intact ions in the substantial absence of fragmentation of the ions to provide a substantially continuous beam of the intact ions for mass analysis. The mass analyzer is connected to the ion guide/accelerator for receipt of the beam of ions and determines the mass to charge ratio of the intact ions.Type: ApplicationFiled: September 28, 2004Publication date: May 5, 2005Inventors: Andrew Krutchinsky, Herbert Cohen, Markus Kalkum, Vadim Sherman, Brian Chait
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Publication number: 20050077460Abstract: Disclosed is an apparatus for examining and inspecting at least one sample in order to determine characteristics of the sample having the a support for receiving a compact disc, the compact disc having deposited on a surface thereof at least one sample, inspection means for effecting a physical change in at least one sample, the inspection means positioned for registration with the surface of the compact disc bearing at least one sample; and a traversal mechanism adapted for reciprocating movement, to move the sample in and out of the path of the inspection means.Type: ApplicationFiled: August 23, 2004Publication date: April 14, 2005Inventors: Andrew Krutchinsky, Brian Chait
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Publication number: 20050069916Abstract: Disclosed are compositions and methods for sensitive detection of one or multiple analytes. In general, the methods involve the use of special label components, referred to as reporter signals, that can be associated with, incorporated into, or otherwise linked to the analytes. In some embodiments, the reporter signals can be altered such that the altered forms of different reporter signals can be distinguished from each other. In some embodiments, sets of reporter signals can be used where two or more of the reporter signals in a set have one or more common properties that allow the reporter signals having the common property to be distinguished and/or separated from other molecules lacking the common property.Type: ApplicationFiled: April 14, 2004Publication date: March 31, 2005Inventors: Brian Chait, Darin Latimer, Paul Lizardi, Eric Kershnar, Jon Morrow, Matthew Roth, Martin Mattessich, Kevin McConnell
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Patent number: 6809318Abstract: A system for determining the ratio of mass to charge of an ion including a pulsed ionizer, a high pressure co-linear ion guide/accelerator, and a mass analyzer. The pulsed ionizer generates intact analyte ions from a sample of matter to be analyzed. The high pressure co-linear ion guide/accelerator is interfaced with the ion source for receipt of the intact ions of the sample. The ion guide/accelerator simultaneously dampens and linearly accelerates the intact ions in the substantial absence of fragmentation of the ions to provide a substantially continuous beam of the intact ions for mass analysis. The mass analyzer is connected to the ion guide/accelerator for receipt of the beam of ions and determines the mass to charge ratio of the intact ions.Type: GrantFiled: September 8, 2003Date of Patent: October 26, 2004Assignee: The Rockefeller UniversityInventors: Andrew Krutchinsky, Herbert Cohen, Markus Kalkum, Vadim Sherman, Brian Chait
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Publication number: 20040056187Abstract: A system for determining the ratio of mass to charge of an ion including a pulsed ionizer, a high pressure co-linear ion guide/accelerator, and a mass analyzer. The pulsed ionizer generates intact analyte ions from a sample of matter to be analyzed. The high pressure co-linear ion guide/accelerator is interfaced with the ion source for receipt of the intact ions of the sample. The ion guide/accelerator simultaneously dampens and linearly accelerates the intact ions in the substantial absence of fragmentation of the ions to provide a substantially continuous beam of the intact ions for mass analysis. The mass analyzer is connected to the ion guide/accelerator for receipt of the beam of ions and determines the mass to charge ratio of the intact ions.Type: ApplicationFiled: September 8, 2003Publication date: March 25, 2004Applicant: THE ROCKEFELLER UNIVERSITYInventors: Andrew Krutchinsky, Herbert Cohen, Markus Kalkum, Vadim Sherman, Brian Chait
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Patent number: 6617577Abstract: A system for determining the ratio of mass to charge of an ion including a pulsed ionizer, a high pressure co-linear ion guide/accelerator, and a mass analyzer. The pulsed ionizer generates intact analyte ions from a sample of matter to be analyzed. The high pressure co-linear ion guide/accelerator is interfaced with the ion source for receipt of the intact ions of the sample. The ion guide/accelerator simultaneously dampens and linearly accelerates the intact ions in the substantial absence of fragmentation of the ions to provide a substantially continuous beam of the intact ions for mass analysis. The mass analyzer is connected to the ion guide/accelerator for receipt of the beam of ions and determines the mass to charge ratio of the intact ions.Type: GrantFiled: April 16, 2001Date of Patent: September 9, 2003Assignee: The Rockefeller UniversityInventors: Andrew Krutchinsky, Herbert Cohen, Markus Kalkum, Vadim Sherman, Brian Chait
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Publication number: 20020148972Abstract: A system for determining the ratio of mass to charge of an ion including a pulsed ionizer, a high pressure co-linear ion guide/accelerator, and a mass analyzer. The pulsed ionizer generates intact analyte ions from a sample of matter to be analyzed. The high pressure co-linear ion guide/accelerator is interfaced with the ion source for receipt of the intact ions of the sample. The ion guide/accelerator simultaneously dampens and linearly accelerates the intact ions in the substantial absence of fragmentation of the ions to provide a substantially continuous beam of the intact ions for mass analysis. The mass analyzer is connected to the ion guide/accelerator for receipt of the beam of ions and determines the mass to charge ratio of the intact ions.Type: ApplicationFiled: April 16, 2001Publication date: October 17, 2002Inventors: Andrew Krutchinsky, Herbert Cohen, Markus Kalkum, Vadim Sherman, Brian Chait
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Publication number: 20020074517Abstract: Disclosed is an apparatus for examining and inspecting at least one sample in order to determine characteristics of the sample having the a support for receiving a compact disc, the compact disc having deposited on a surface thereof at least one sample, inspection means for effecting a physical change in at least one sample, the inspection means positioned for registration with the surface of the compact disc bearing at least one sample; and a traversal mechanism adapted for reciprocating movement, to move the sample in and out of the path of the inspection means.Type: ApplicationFiled: December 15, 2000Publication date: June 20, 2002Inventors: Andrew Krutchinsky, Brian Chait