Patents by Inventor Brian Chekal

Brian Chekal has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for the preparation of 3-(4-(2,4-difluorobenzyloxy)-3-bromo-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide
    Patent number: 7906536
    Abstract: This invention is directed generally to processes for the preparation of compounds of Formula I: wherein R2, R3, R4, R5, X1, X2, X3, X4, X5, X6 are as defined in the specification.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: March 15, 2011
    Assignee: Pfizer Inc
    Inventors: Daniel Dukesherer, Michael Mao, Richard Vonder Embse, Gopi Yalamanchili, Rajappa Vaidyanathan, Brian Chekal, George Klemm, Ronald VanderRoest, Randy Geurink
  • PROCESSES FOR THE PREPARATION OF 3-(4-(2,4-DIFLUOROBENZYLOXY)-3-BROMO-6-METHYL-2-OXOPYRIDIN-1(2H)-YL)-N,4-DIMETHYLBENZAMIDE
    Publication number: 20080177077
    Abstract: This invention is directed generally to processes for the preparation of compounds of Formula I: wherein R2, R3, R4, R5, X1, X2, X3, X4, X5, X6 are as defined in the specification.
    Type: Application
    Filed: December 12, 2007
    Publication date: July 24, 2008
    Inventors: Daniel Dukesherer, Michael Mao, Richard Vonder Embse, Gopi Yalamanchili, Rajappa Vaidyanathan, Brian Chekal, George Klemm, Ronald VanderRoset, Randy Geurink
  • Enantioselective separation method
    Publication number: 20060020022
    Abstract: This invention relates to a method for separating enantiomers of a substituted 2-trifluoromethyl-2H-chromene-3-carboxylic acid or ester, a substituted 2-trifluoromethyl-1,2-dihydro-quinoline-3-carboxylic acid or ester, a substituted 2-trifluoromethyl-2H-thiochromene-3-carboxylic acid or ester, a substituted 3-trifluoromethyl-3,4-dihydro-naphthalene-2-carboxylic acid or ester, or a pharmaceutically acceptable salt of the acids or esters, using enantioselective fractional crystallization, enantioselective high performance liquid chromatography, enantioselective steady state recycling chromatography, or enantioselective multicolumn chromatography.
    Type: Application
    Filed: July 22, 2005
    Publication date: January 26, 2006
    Inventors: Brian Chekal, Ernst Freund, Charles Minard Grill, Elke Huthmann, Markus Juza, Vera Leshchinskaya, Mark Thomas Maloney, Lawrence Marvin Miller, Ying Wang, Ming Zeng
  • Photoracamization method
    Publication number: 20060016683
    Abstract: This invention relates to a method for photoracemizing enantiomers of a substituted 2-trifluoromethyl-2H-chromene-3-carboxylic acid or ester, a substituted 2-trifluoromethyl-1,2-dihydro-quinoline-3-carboxylic acid or ester, a substituted 2-trifluoromethyl-2H-thiochromene-3-carboxylic acid or ester, or a pharmaceutically acceptable salt of the acids or esters, using a high intensity UV light source.
    Type: Application
    Filed: July 22, 2005
    Publication date: January 26, 2006
    Inventors: Brian Chekal, Wendell Phillips, Jeffrey Carter