Abstract: The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

Abstract: A compound having the structures: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of said compound or pharmaceutically acceptable salt, wherein; R selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy and —(CH2)m—W, where W is C3-C8 cycloalkyl, bicycloalkyl, bridged bicycloalkyl, phenyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two or three heteroatoms selected from the group consisting of N, S and O atoms; wherein each of said alkyl, cycloalkyl, alkoxy, heterocyclic, phenyl, naphthyl or heteroaryl may be unsubstituted or substituted by phenyl, halo, cyano, deuterium, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, —SO2—R?, —CONR?R?, NR?COR?, —NR?CONR?R?, —NR?CO2R?, —(CH2)n—SO2—R?, —NHSO2—R?, —NR?SO2—R?, —SO2NR?R?, NR?R? or SR? where R? and R? are independently H, C1-C6 alkyl or C3-C8 cycloalkyl; R1 selected from the group consisting of phenyl, naphthyl, 5- or 6-membered heteroaryl or heterocyclic containing one, two, three or four heteroatoms se

Abstract: This disclosure provides systems and methods for the on-demand synthesis, separation, purification and formulation of chemicals, and particularly for the on-demand production of pharmaceutical products. More particularly, the disclosure provides continuous-flow on-demand systems, comprising one or more reagent holding/dispensing containers, continuous-flow chemical synthesis modules and/or one or more separation, crystallization, filtration, wash and/or formulation modules, additionally comprising automated detection systems and methods for monitoring reagents, products and processing parameters and automated control systems and methods for controlling processing conditions and parameters.

Abstract: The present invention provides compounds useful for the treatment of narcolepsy or cataplexy in a subject in need thereof. Related pharmaceutical compositions and methods are also provided herein.

Abstract: Systems and methods include providing a user interface visualizing a current state of an optical network; receiving user inputs related to capacity mining in the optical network; determining a future state with the capacity mining based on the user inputs; and providing the user interface visualizing the future state. The future state can be presented with respect to a failed link and restoration of traffic on the failed link. The future state can include a plurality of plans with a visualization showing how much of the traffic is restored based on different approaches to the capacity mining. The capacity mining can include configuring optical modems based on determined available excess capacity.

Abstract: A method of simulating an integrated circuit includes providing at least one test case to a simulation tool, obtaining at least one first simulation result and at least one first simulation log from the simulation tool, classifying, with a first machine learning model, the at least one test case into one fail class of a plurality of fail classes, generating at least one renewed test case by applying, with a controller, a solution to the at least one test case, and providing the at least one renewed test case to the simulation tool.

Abstract: Systems and methods include providing a user interface visualizing a current state of an optical network; receiving user inputs related to capacity mining in the optical network; determining a future state with the capacity mining based on the user inputs; and providing the user interface visualizing the future state. The future state can be presented with respect to a failed link and restoration of traffic on the failed link. The future state can include a plurality of plans with a visualization showing how much of the traffic is restored based on different approaches to the capacity mining. The capacity mining can include configuring optical modems based on determined available excess capacity.

Abstract: Systems and methods for managing optical network services in an optical network include providing a user interface illustrating a current state of the optical network; performing analysis based on user input related to an event affecting the current state of the optical network to determine a first future state of the optical network; providing an updated user interface illustrating the first future state based on the analysis; performing an updated analysis based on updated user input received in response to the first future to determine a second future state of the optical network; and providing a further updated user interface illustrating the second future state.

Abstract: A simulation for sensor data may be evaluated and used for future simulations for an autonomous vehicle software. The method includes receiving log data collected for an environment along a given run for a given vehicle, using a software for autonomous driving to perform a simulated run of the given run using logged sensor data from the log data and environment data constructed using the log data, and determining first details regarding detection of objects during the given run using logged sensor data. The method also includes using the software to run a simulation of one or more detection devices on a simulated vehicle driving along the given run to obtain simulated sensor data, and determining second details regarding detection of objects using the simulated sensor data. Metrics may then be extracted from the first details and the second details, and the simulation may be evaluated based on the metrics.

Abstract: Systems and methods for managing optical network services in an optical network include providing a user interface illustrating a current state of the optical network; performing analysis based on user input related to an event affecting the current state of the optical network to determine a first future state of the optical network; providing an updated user interface illustrating the first future state based on the analysis; performing an updated analysis based on updated user input received in response to the first future to determine a second future state of the optical network; and providing a further updated user interface illustrating the second future state.

Abstract: A method of assessing an area for parking a vehicle includes ultrasonically scanning the area to obtain ultrasonic data, radar scanning the area to obtain radar data, and determining whether to park the vehicle in the area based on both the ultrasonic data and the radar data.

Abstract: Parking assistance for a vehicle includes various elements directed to assessing whether a motion or position of a vehicle is conducive to detecting an available parking slot. In one instance, a signal is received, and the signal is used to calculate a movement parameter. For example, the movement parameter might include a distance between the driven vehicle and one or more objects or a passing angle of the driven vehicle relative to the one or more objects. The movement parameter is then compared to a movement parameter threshold, and a notification is transmitted when the movement parameter is violated.

Abstract: A method of determining an object distance from a vehicle includes sending a first transmission signal during a first burst period from a first transmitter, listening for a first reflection signal during a first listen period in a receiver, and sending a second transmission signal during a second burst period from a second transmitter. The second transmission signal is sent based on a time when the first transmission signal is sent.

Abstract: Parking assistance for a vehicle includes various elements directed to assessing whether a motion or position of a vehicle is conducive to detecting an available parking slot. In one instance, a signal is received, and the signal is used to calculate a movement parameter. For example, the movement parameter might include a distance between the driven vehicle and one or more objects or a passing angle of the driven vehicle relative to the one or more objects. The movement parameter is then compared to a movement parameter threshold, and a notification is transmitted when the movement parameter is violated.

Abstract: A method of parking a running vehicle includes measuring a length of a parked vehicle that is proximate to a desired parking location, and estimating the width of the parked vehicle based on a regression equation. The running vehicle is parked based on the estimated width.

Abstract: A method of parking a running vehicle includes measuring a length of a parked vehicle that is proximate to a desired parking location, and estimating the width of the parked vehicle based on a regression equation. The running vehicle is parked based on the estimated width.

Abstract: A method of determining an object distance from a vehicle includes sending a first transmission signal during a first burst period from a first transmitter, listening for a first reflection signal during a first listen period in a receiver, and sending a second transmission signal during a second burst period from a second transmitter. The second transmission signal is sent based on a time when the first transmission signal is sent.

Abstract: A method of assessing an area for parking a vehicle includes ultrasonically scanning the area to obtain ultrasonic data, radar scanning the area to obtain radar data, and determining whether to park the vehicle in the area based on both the ultrasonic data and the radar data.

Abstract: A test system for facilitating determining whether a plasma processing system (which includes a plasma processing chamber) is ready for processing wafers. The test system may include a computer-readable medium storing at least a test program. The test program may include code for receiving electric parameter values derived from signals detected by at least one sensor when no plasma is present in the plasma processing chamber. The test program may also include code for generating electric model parameter values using the electric parameter values and a mathematical model. The test program may also include code for comparing the electric model parameter values with baseline model parameter value information. The test program may also include code for determining readiness of the plasma processing system based on the comparison. The test system may also include circuit hardware for performing one or more tasks associated with the test program.

Abstract: A method of altering the conformation of a polypeptide having a known three-dimensional structure is described. The method comprises attaching a first end of a polymer to a first portion of the polypeptide, attaching a second end of the polymer to a second portion of the polypeptide, and altering the mechanical tension of the polymer, thereby altering the conformation of the polypeptide. The alteration of the conformation of the polypeptide may increase or decrease the binding affinity of the polypeptide for a substrate bound by the polypeptide, or alter the catalytic rate of an enzyme. Typically, the polymer is a polynucleotide or polypeptide.