Abstract: The present disclosure provides a method for enrichment of at least one target nucleic acid in a library of nucleic acids. A first oligonucleotide is hybridized to a target nucleic acid in library of nucleic acids having first and second adapters. The hybridized first oligonucleotide is extended with a first polymerase, thereby producing a first primer extension complex including the target nucleic acid and the extended first oligonucleotide. The first primer extension complex is captured, enriched relative to the library of nucleic acids, and a second oligonucleotide is hybridized to the target nucleic acid. The hybridized second oligonucleotide is extended with a second polymerase, thereby producing a second primer extension complex including the target nucleic acid and the extended second oligonucleotide and further liberating the extended first oligonucleotide from the first primer extension complex.

Abstract: The present invention is a method and compositions for primer extension target enrichment of nucleic acids and improvements thereto including simultaneously enriching for RNA and DNA and optionally sequencing the enriched products.

Abstract: A method and system used to control a rotational speed or a torque of an output drive shaft. The output drive shaft being coupled to a turbine engine. The turbine engine including an engine core and an engine starter assembly. The engine starter assembly including an air turbine starter, an output drive shaft and an electric motor.

Abstract: Embodiments are directed towards a computer-implemented method for identifying one or more matching elements from a taxonomy present in a document. The method may include identifying the document, the taxonomy, and a question that may be processed by a large language model (LLM). The method may further include applying at least one taxonomy augmented generation (TAG) tactic from a set of TAG tactics to the identified document and to the identified taxonomy. The method may also include generating an input prompt that may be configured to be used as an input for the LLM, where the input prompt may include a document context derived from the document, a taxonomy context derived from the taxonomy, and the question to be processed by the LLM. The method may further include providing the input prompt to the LLM, and receiving a response generated by the LLM.

Abstract: Systems, methods, apparatuses, and devices, for the wireless communication of analyte data are provided. In some embodiments, a method and calibration station for calibrating a continuous analyte sensor system is provided. Methods and testing systems for testing a continuous analyte sensor system is provided. Continuous analyte sensor systems, display devices and peripheral devices configured for wireless communication of analyte, connection, alarm and/or alert data and associated methods are provided.

Abstract: An embodiment provides new joiners to a conversation with access to historical keys using an encrypted skip list that can be safely stored on untrusted servers. This list provides random access to conversation content with logarithmic complexity (queries and data size), and imposes small (log-scale) overhead on linear/full access to the conversation content.

Abstract: The present disclosure relates to adjusting and maintaining a position of a cutting surface used to create lines of weakness for rolled products.

Abstract: Methods, devices and systems are disclosed for inter-app communications between software applications on a mobile communications device. In one aspect, a computer-readable medium on a mobile computing device comprising an inter-application communication data structure to facilitate transitioning and distributing data between software applications in a shared app group for an operating system of the mobile computing device includes a scheme field of the data structure providing a scheme id associated with a target software app to transition to from a source software app, wherein the scheme id is listed on a scheme list stored with the source software app; and a payload field of the data structure providing data and/or an identification where to access data in a shared file system accessible to the software applications in the shared app group, wherein the payload field is encrypted.

Abstract: A turbine engine having an engine core having a compression section, combustion section, a turbine section, and an engine drive shaft. The turbine engine includes an air turbine starter having a housing defining an air flow passage. The air turbine starter can operate in a start-up mode and a shut-down mode. The turbine engine further includes a gearbox and a drive unit.

Abstract: A turbine engine having an engine core having a compression section, combustion section, a turbine section, and an engine drive shaft. The turbine engine includes an air turbine starter having a housing defining an air flow passage. The air turbine starter can operate in a start-up mode and a shut-down mode. The turbine engine further includes a gearbox and a drive unit.

Abstract: The present invention is a method and compositions for primer extension target enrichment of nucleic acids and improvements thereto including simultaneously enriching for RNA and DNA and optionally sequencing the enriched products.

Abstract: A turbine engine including an engine core, an engine drive shaft, an accessory gear box (AGB), an air turbine starter (ATS), and a bleed air circuit. The engine core has a fan section, a compressor section, a combustion section, and a turbine section in serial flow arrangement. The engine drive shaft operably couples the fan section, the compressor section, and the turbine section. The AGB and the ATS are operably coupled to the engine drive shaft.

Abstract: A turbine engine including an engine core, an engine drive shaft, an accessory gear box (AGB), an air turbine starter (ATS), and a bleed air circuit. The engine core has a fan section, a compressor section, a combustion section, and a turbine section in serial flow arrangement. The engine drive shaft operably couples the fan section, the compressor section, and the turbine section. The AGB and the ATS are operably coupled to the engine drive shaft.

Abstract: Systems and methods for remote and host monitoring communication are disclosed. In some implementations, monitoring systems can comprise a host monitoring device associated with a Host communicatively coupled to one or more remote monitoring devices associated with Remote Monitors. The host monitoring device can send communications based at least in part on analyte measurements of a Host sensor and/or other contextual data giving such measurements context. Different remote monitoring devices can receive different communications based at least in part on the role of the respective Remote Monitors relative to the Host. These roles can be reflected in classifications of Remote Monitors.

Abstract: Methods and apparatuses are described for dialog control flow in information retrieval applications. A server establishes a chat-based communication session between an information retrieval application and a client device. The server determines a user intent from utterances received from a user of the client device and initiates a first dialog workflow associated with the user intent. The server invokes NLP services using the utterances to determine a comprehension score for the user intent and identifies a first one of the NLP services to continue the first dialog workflow when the comprehension score is at or above a threshold value, including generating a response to the utterances using the first NLP service. The server delegates the communication session to a second dialog workflow when the comprehension score is below the threshold value, including invoking a generalized language processing service associated with the second dialog workflow using the user intent to generate a response to the utterances.

Abstract: A combustor assembly for a gas turbine engine including an outer casing, the gas turbine engine defining an axial direction, the combustor assembly includes a liner at least partially defining a combustion chamber extending between an aft end and a forward end generally along the axial direction within the outer casing, the liner including an inner surface facing the combustion chamber and an outer surface facing away from the combustion chamber, and a damper assembly extending between the outer casing and the outer surface of the liner, the damper assembly including a selectively separable support and a damper spring, the damper spring being disposed between the support and the liner.

Abstract: The present disclosure provides a method for enrichment of at least one target nucleic acid in a library of nucleic acids. A first oligonucleotide is hybridized to a target nucleic acid in library of nucleic acids having first and second adapters. The hybridized first oligonucleotide is extended with a first polymerase, thereby producing a first primer extension complex including the target nucleic acid and the extended first oligonucleotide. The first primer extension complex is captured, enriched relative to the library of nucleic acids, and a second oligonucleotide is hybridized to the target nucleic acid. The hybridized second oligonucleotide is extended with a second polymerase, thereby producing a second primer extension complex including the target nucleic acid and the extended second oligonucleotide, and further liberating the extended first oligonucleotide from the first primer extension complex.

Abstract: A continuous glucose monitor for wirelessly transmitting data relating to glucose value to a plurality of displays is disclosed, as well as systems and methods for limiting the number of display devices that can connect to a continuous glucose transmitter. In addition, security, including hashing techniques and a changing application key, can be used to provide secure communications between the continuous glucose transmitter and the displays. Also provided is a continuous glucose monitor and techniques for authenticating multiple displays, providing secure data transmissions to multiple displays, and coordinating the interaction of commands and data updates between multiple displays.

Abstract: The invention relates to processes for preparing isoindolin-1-one derivatives, and in particular processes for preparing (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid. The invention also relates to crystalline forms of the compound (2S,3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[(1S)-1-hydroxy-1-(oxan-4-yl)propyl]-1-methoxy-3-oxo-2,3-dihydro-1H-isoindol-2-yl]-2-methylpropanoic acid and its salts.

Abstract: A pitch energy module comprising one or more ultracapacitors storing electrical energy for a wind turbine emergency pitch energy event. The pitch energy module replaces at least one battery within a battery housing of a wind turbine and interfaces with the existing battery wiring harness to communicate with a control system of the wind turbine. The pitch energy module is installed without further modification to the battery housing or the battery wiring harness.