Abstract: A method of detecting tissue oedema in a subject. The method includes determining a measured impedance for first and second body segments. An index indicative of a ratio of the extra-cellular to intra-cellular fluid is then calculated for each body segment, with these being used to determine an index ratio based on the index for the first and second body segments. The index ration can in turn be used to determine the presence, absence or degree of tissue oedema, for example by comparing the index ratio to a reference or previously determined index ratios.

Abstract: A method of detecting tissue oedema in a subject. The method includes determining a measured impedance for first and second body segments. An index indicative of a ratio of the extra-cellular to intra-cellular fluid is then calculated for each body segment, with these being used to determine an index ratio based on the index for the first and second body segments. The index ration can in turn be used to determine the presence, absence or degree of tissue oedema, for example by comparing the index ratio to a reference or previously determined index ratios.

Abstract: A biological function is controlled via the autonomous delivery of formulations administered at a single site, by determining each of the preferred formulations having efficacy in effecting control of at least one stage of a preferred biological function and includes features of improved permeation of formulations to effect desired bioavailability at a preferred level for a preferred period of time, one or more preferred formulations, in predetermined concentrations, in predetermined quantities, delivered at predetermined time intervals and over predetermined periods, and the delivery regimes for delivery of the formulations to achieve the outcome required. The formulations are delivered via a substance delivery device retained in location at a specific site for at least the delivery period. The device is adapted to house the formulations and the control and delivery apparatus required to effect controlled release of the formulations in accordance with the delivery regime.

Abstract: A substance delivery device capable of insertion into a body cavity of an animal, with the delivery device including a body capable of housing a delivery apparatus capable of actively being controlled to autonomously deliver at least one substance into a body cavity of an animal, with the delivery apparatus including dedicated pressure systems to deliver the at least one substance from independent reservoirs via at least one associated outlet, with the at least one substance ranging in form from substantially fluid to substantially solid, with the device also including a programmable control device capable of initiating and regulating delivery of the at least one substance in accordance with a preferred delivery regime, and with the body further including a tail portion adapted to receive retention apparatus external to the animal and capable of effecting retention of the substance delivery device within the body cavity of an animal.