Abstract: Provided are binding molecules, such as TCRs or antigen binding fragments thereof and antibodies and antigen-binding fragments thereof, such as those that recognize or bind human papilloma virus (HPV) 16, including HPV 16 E6 and HPV 16 E7. Also provided are engineered cells containing such binding molecules, compositions containing the binding molecules or engineered cells, and methods of treatment, such as administration of the binding molecules, engineered cells, or compositions.

Abstract: This invention relates to an apparatus for an apparatus for processing a fluid sample comprising: (i) a sample processing chamber comprising a fluid inlet and a fluid outlet; (ii) a waste chamber downstream from the sample processing chamber and in fluid communication with the sample processing chamber fluid outlet and wherein the fluid communication between the sample processing chamber outlet and the waste chamber comprises a divergent analyte flow path; (iii) at least two further chambers up stream from the sample processing chamber both of which are in fluid communication with the sample processing chamber fluid inlet; (iv) a means for moving fluid from each of the at least two further chambers through the sample processing chamber and into the waste chamber or into the divergent analyte flow path as desired by applying positive or negative pressure to the desired flow path; and (v) a passive means for restricting the flow of fluid. This invention also relates to a method and use of the same.

Abstract: This invention relates to a method and associated apparatus for isolating a known volume of sample solution comprising: (i) taking an apparatus comprising a first chamber with a sealing means, a second chamber, wherein said first and said second chamber are connected via a duct and collecting the sample solution into the first chamber of the apparatus; and (ii) pumping a pre-determined known volume of the sample solution into the second chamber of the apparatus. The sample solution of the present invention preferably comprises a nucleic acid target material. This invention also relates to a single integrated apparatus and a kit capable of performing the same.

Abstract: A handle grip system for ergonomically positioning a rider's hands upon the handlebars. The handle grip system includes a main body having a front portion and a rear portion, an inner flange extending from an inner end of the main body, an outer flange extending from a distal end of the main body, and a stop member extending from the front portion near the inner flange for receiving the index finger of the rider. A straight bore extends through the main body from the inner end for snugly fitting upon a handlebar. The rear portion preferably has a convex structure with a plurality of rear channels within. The front portion preferably has a concave structure extending from the stop member to the outer flange. The main body preferably has an oblong cross sectional structure with the width being greater than the height. An outer channel and an inner channel preferably extend completely about the perimeter of the inner section and outer section of the main body respective.

Abstract: A rolling element bearing comprises two bearing races between which is disposed a cage including rolling elements, the radially innermost cylindrical surface of the cage including oil reservoirs and the inner race including lips which during operation of the bearing contact the oil within the reservoirs whereby the speed of the cage is adapted to be controlled by the inner race.