Abstract: Novel biodegradable compositions are disclosed. The biodegradable compositions include at least one hydroxyl-terminated component and at least one bioactive peptide in a linear chain. The compositions may be utilized as medical devices including drug delivery devices, tissue adhesives and/or sealants.

Abstract: The present disclosure relates to compositions comprising a copolymer that includes a first monomer and a second monomer that is different from the first monomer, wherein both the first and second monomer are selected from the group consisting of 3-sulfopropyl acrylate potassium salt, sodium acrylate, N-(tris(hydroxyl methyl)methyl)acrylamide, and 2-acrylamideo-2-methyl-1-propane sulfonic acid. The present disclosure further relates to methods for preparing the copolymer compositions and shaped articles comprising the copolymers.

Abstract: A bioactive sol-gel solution includes a biocompatible polymer, a gelable inorganic base material, and at least one calcium and phosphorous molecular species. The base material can be an alkoxide, such as TEOS. The polymer acts as a viscosity modifier to the sol or gel, increases the viscosity range over which fibers can be sprayed or spun, and broadens the time period over which fibers can be sprayed or spun. A bioactive glass composite can be formed from the bioactive sol-gel solution, including a fibrous form. Fibers can serve as a scaffold for cell growth and in the repair of hard or soft tissue defects.

Abstract: The present disclosure describes a coating for a surgical filament including a vinyl lactam polymer and a lactone polymer.

Abstract: An inflatable balloon cuff with a water-swellable coating may be adapted to seal a patient's trachea when associated with an endotracheal tube. The water-swellable coating may enhance a cuffs mechanical pressure seal. The water-swellable coating may be loosely adhered or not adhered to the cuff in order to allow the coating to flow into and seal any leak paths that may form when the cuff is inflated in a patient's trachea.

Abstract: The present disclosure relates to compositions comprising a copolymer that includes a first monomer and a second monomer that is different from the first monomer, wherein both the first and second monomer are selected from the group consisting of 3-sulfopropyl acrylate potassium salt, sodium acrylate, N-(tris(hydroxyl methyl)methyl)acrylamide, and 2-acrylamideo-2-methyl-1-propane sulfonic acid. The present disclosure further relates to methods for preparing the copolymer compositions and shaped articles comprising the copolymers.

Abstract: The present disclosure relates to compositions comprising a copolymer that includes a first monomer and a second monomer that is different from the first monomer, wherein both the first and second monomer are selected from the group consisting of 3-sulfopropyl acrylate potassium salt, sodium acrylate, N-(tris(hydroxyl methyl)methyl)acrylamide, and 2-acrylamide-2-methyl-1-propane sulfonic acid. The present disclosure further relates to methods for preparing the copolymer compositions and shaped articles comprising the copolymers.

Abstract: The present disclosure relates to compositions comprising a copolymer that includes a first monomer and a second monomer that is different from the first monomer, wherein both the first and second monomer are selected from the group consisting of 3-sulfopropyl acrylate potassium salt, sodium acrylate, N-(tris(hydroxyl methyl)methyl)acrylamide, and 2-acrylamideo-2-methyl-1-propane sulfonic acid. The present disclosure further relates to methods for preparing the copolymer compositions and shaped articles comprising the copolymers.

Abstract: The present disclosure relates to compositions comprising a copolymer that includes a first monomer and a second monomer that is different from the first monomer, wherein both the first and second monomer are selected from the group consisting of 3-sulfopropyl acrylate potassium salt, sodium acrylate, N-(tris(hydroxyl methyl)methyl)acrylamide, and 2-acrylamideo-2-methyl-1-propane sulfonic acid. The present disclosure further relates to methods for preparing the copolymer compositions and shaped articles comprising the copolymers.

Abstract: The present disclosure relates to compositions comprising a copolymer that includes a first monomer and a second monomer that is different from the first monomer, wherein both the first and second monomer are selected from the group consisting of 3-sulfopropyl acrylate potassium salt, sodium acrylate, N-(tris(hydroxyl methyl)methyl)acrylamide, and 2-acrylamide-2-methyl-1-propane sulfonic acid. The present disclosure further relates to methods for preparing the copolymer compositions and shaped articles comprising the copolymers.

Abstract: The present disclosure is directed to polymers having hydroxyl containing bioactive agents incorporated into the backbone of the polymer or attached thereto by pendant linkages. Hydroxyl containing bioactive agents which may be attached to these polymers include antimicrobial agents such as triclosan. The polymers may be utilized to form medical devices or coatings for such devices. The hydroxyl containing bioactive agent may be released from the polymer upon hydrolysis of the polymeric backbone or pendant linkage in vivo.

Abstract: The present disclosure relates to compositions comprising a copolymer that includes a first monomer and a second monomer that is different from the first monomer, wherein both the first and second monomer are selected from the group consisting of 3-sulfopropyl acrylate potassium salt, sodium acrylate, N-(tris(hydroxyl methyl)methyl)acrylamide, and 2-acrylamideo-2-methyl-1-propane sulfonic acid. The present disclosure further relates to methods for preparing the copolymer compositions and shaped articles comprising the copolymers.

Abstract: The present disclosure is directed to polymers having hydroxyl containing bioactive agents incorporated into the backbone of the polymer or attached thereto by pendant linkages. Hydroxyl containing bioactive agents which may be attached to these polymers include antimicrobial agents such as triclosan. The polymers may be utilized to form medical devices or coatings for such devices. The hydroxyl containing bioactive agent may be released from the polymer upon hydrolysis of the polymeric backbone or pendant linkage in vivo.

Abstract: Compositions are provided which include a polymer made at least in part from a polyoxyalkylene copolymer, such as a poloxamer. The polymer may be combined with a second component to form a blend or emulsion. The resulting composition may be utilized to form medical devices, drug delivery devices, or coatings for other medical devices.

Abstract: Novel biodegradable compositions are disclosed. The biodegradable compositions include at least one hydroxyl-terminated component and at least one bioactive peptide in a linear chain. The compositions may be utilized as medical devices including drug delivery devices, tissue adhesives and/or sealants.

Abstract: Novel silver-triclosan salts are provided which have antimicrobial properties and may be used as pharmaceutical compositions or to treat articles such as medical devices, packaging materials, and textiles.

Abstract: The present disclosure describes a coating for a surgical suture including a vinyl lactam polymer and a lactone polymer.

Abstract: A seal assembly for use with an access apparatus during a surgical procedure includes a housing defining a longitudinal axis and having a passageway dimensioned to permit passage of an object. The housing is adapted for mounting to a surgical access apparatus and has internal wall portions defining an internal chamber. A seal is mounted within the internal chamber of the housing and is adapted to form a substantial sealing relation with the object. The seal is mounted for reciprocal movement within the internal chamber in a general transverse direction to the longitudinal axis. A viscous fluid is disposed within the internal chamber surrounding the seal and is adapted to form a substantial seal between the seal and the internal wall portions of the housing. The fluid may have lubricious characteristic to facilitate sliding movement of the seal relative to the internal wall portions of the housing.

Abstract: Braids and surgical devices are made from yarns that include a core sheath construction with at least one yarn made from a thermoplastic elastomer and at least one yarn made from a polyolefin material.

Abstract: The present disclosure describes a coating for a surgical filament including a vinyl lactam polymer and a lactone polymer.