Patents by Inventor Brian D. Andresen
Brian D. Andresen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20070254827Abstract: A method of remediation of one or more of an animal, mineral, or vegetable for beryllium. The method includes the steps of applying ?-aminobenzyl-?,?,-diphosphoric acid to the one or more of the animal, mineral, or vegetable; and allowing chelation of the beryllium.Type: ApplicationFiled: March 30, 2007Publication date: November 1, 2007Inventors: Mark Sutton, Stephen R. Burastero, Julie Perkins, Marina L. Chiarappa-Zucca, Brian D. Andresen
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Patent number: 7247273Abstract: A thin layer chromatograph residue applicator sampler. The residue applicator sampler provides for rapid analysis of samples containing high explosives, chemical warfare, and other analyses of interest under field conditions. This satisfied the need for a field-deployable, small, hand-held, all-in-one device for efficient sampling, sample dissolution, and sample application to an analytical technique. The residue applicator sampler includes a sampling sponge that is resistant to most chemicals and is fastened via a plastic handle in a hermetically sealed tube containing a known amount of solvent. Upon use, the wetted sponge is removed from the sealed tube and used as a swiping device across an environmental sample. The sponge is then replaced in the hermetically sealed tube where the sample remains contained and dissolved in the solvent. A small pipette tip is removably contained in the hermetically sealed tube.Type: GrantFiled: August 27, 2002Date of Patent: July 24, 2007Assignee: The Regents of the University of CaliforniaInventors: Peter J. Nunes, Fredrick R. Kelly, Jeffrey S. Haas, Brian D. Andresen
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Patent number: 7125580Abstract: A sample collection substrate of aerogel and/or xerogel materials bound to a support structure is used as a solid phase microextraction (SPME) device. The xerogels and aerogels may be organic or inorganic and doped with metals or other compounds to target specific chemical analytes. The support structure is typically formed of a glass fiber or a metal wire (stainless steel or kovar). The devices are made by applying gel solution to the support structures and drying the solution to form aerogel or xerogel. Aerogel particles may be attached to the wet layer before drying to increase sample collection surface area. These devices are robust, stable in fields of high radiation, and highly effective at collecting gas and liquid samples while maintaining superior mechanical and thermal stability during routine use. Aerogel SPME devices are advantageous for use in GC/MS analyses due to their lack of interfering background and tolerance of GC thermal cycling.Type: GrantFiled: June 6, 2005Date of Patent: October 24, 2006Assignee: The Regents of the University of CaliforniaInventors: Fred S. Miller, Brian D. Andresen
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Patent number: 6929778Abstract: A field kit for the collection, isolation and concentration of trace amounts of high explosives (HE), biological weapons (BW) and chemical weapons (CW) residues in air, soil, vegetation, swipe, and liquid samples. The field kit includes a number of Solid Phase Microextraction (SPME) fiber and syringe assemblies in a hermetically sealed transportation container or tubes which includes a sampling port, a number of extra SPME fiber and syringe assemblies, the fiber and syringe assemblies including a protective cap for the fiber, and an extractor for the protective cap, along with other items including spare parts, protective glove, and an instruction manual, all located in an airtight container.Type: GrantFiled: April 12, 2001Date of Patent: August 16, 2005Assignee: The Regents of the University of CaliforniaInventors: Peter J. Nunes, Brian D. Andresen
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Patent number: 6905031Abstract: A sample collection substrate of aerogel and/or xerogel materials bound to a support structure is used as a solid phase microextraction (SPME) device. The xerogels and aerogels may be organic or inorganic and doped with metals or other compounds to target specific chemical analytes. The support structure is typically formed of a glass fiber or a metal wire (stainless steel or kovar). The devices are made by applying gel solution to the support structures and drying the solution to form aerogel or xerogel. Aerogel particles may be attached to the wet layer before drying to increase sample collection surface area. These devices are robust, stable in fields of high radiation, and highly effective at collecting gas and liquid samples while maintaining superior mechanical and thermal stability during routine use. Aerogel SPME devices are advantageous for use in GC/MS analyses due to their lack of interfering background and tolerance of GC thermal cycling.Type: GrantFiled: September 13, 1999Date of Patent: June 14, 2005Assignee: The Regents of the University of CaliforniaInventors: Fred S. Miller, Brian D. Andresen
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Patent number: 6871556Abstract: A porous protective sheath for active extraction media used in solid phase microextraction (SPME). The sheath permits exposure of the media to the environment without the necessity of extending a fragile coated fiber from a protective tube or needle. Subsequently, the sheath can pierce and seal with GC-MS septums, allowing direct injection of samples into inlet ports of analytical equipment. Use of the porous protective sheath, within which the active extraction media is contained, mitigates the problems of: 1) fiber breakage while the fiber is extended during sampling, 2) active media coating loss caused by physical contact of the bare fiber with the sampling environment; and 3) coating slough-off during fiber extension and retraction operations caused by rubbing action between the fiber and protective needle or tube.Type: GrantFiled: July 27, 2001Date of Patent: March 29, 2005Assignee: The Regents of the University of CaliforniaInventors: Brian D. Andresen, Erik Randich
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Publication number: 20040258617Abstract: Chemical or isotopic labels are added to, e.g., a potentially lethal drug formulation, to generate a unique chemical fingerprint. Combinations of chemical additives are mixed with the drug to aid in their isolation and identification, especially when such drugs are used for illicit purposes. When stable isotopes are incorporated into lethal drugs, the labeling process conveys a very unique internal chemical signature and greatly aids in the identification of the parent drug in body fluids and tissues. When heath-care providers become aware that certain drugs can now be easily tracked and identified in a victim, individuals may be reluctant to utilize these agents for ill purposes.Type: ApplicationFiled: June 17, 2003Publication date: December 23, 2004Applicant: Pearl Technology Holdings, LLC.Inventors: Paul J. Weber, Brian D. Andresen
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Patent number: 6749826Abstract: Airborne or aqueous organic compound collection using carbon nanotubes. Exposure of carbon nanotube-coated disks to controlled atmospheres of chemical warefare (CW)-related compounds provide superior extraction and retention efficiencies compared to commercially available airborne organic compound collectors. For example, the carbon nanotube-coated collectors were four (4) times more efficient toward concentrating dimethylmethyl-phosphonate (DMMP), a CW surrogate, than Carboxen, the optimized carbonized polymer for CW-related vapor collections. In addition to DMMP, the carbon nanotube-coated material possesses high collection efficiencies for the CW-related compounds diisopropylaminoethanol (DIEA), and diisopropylmethylphosphonate (DIMP).Type: GrantFiled: June 5, 2002Date of Patent: June 15, 2004Assignee: The Regents of the University of CaliforniaInventors: Thomas M. Tillotson, Brian D. Andresen, Armando Alcaraz
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Publication number: 20040042934Abstract: A thin layer chromatograph residue applicator sampler. The residue applicator sampler provides for rapid analysis of samples containing high explosives, chemical warfare, and other analyses of interest under field conditions. This satisfied the need for a field-deployable, small, hand-held, all-in-one device for efficient sampling, sample dissolution, and sample application to an analytical technique. The residue applicator sampler includes a sampling sponge that is resistant to most chemicals and is fastened via a plastic handle in a hermetically sealed tube containing a known amount of solvent. Upon use, the wetted sponge is removed from the sealed tube and used as a swiping device across an environmental sample. The sponge is then replaced in the hermetically sealed tube where the sample remains contained and dissolved in the solvent. A small pipette tip is removably contained in the hermetically sealed tube.Type: ApplicationFiled: August 27, 2002Publication date: March 4, 2004Applicant: The Regents of the University of CaliforniaInventors: Peter J. Nunes, Fredrick R. Kelly, Jeffrey S. Haas, Brian D. Andresen
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Publication number: 20030022389Abstract: The use of treated and/or impregnated aerogels, for chemical specific adsorption, as a sample collection media. The chemically specific aerogel provides an adsorbate as a sampling medium for airborne applications such as stack emissions, clean room environments, personnel dosimetry, etc. The aerogel is treated and/or impregnated to adsorb specific chemistries. The aerogel, after adsorption of a specific chemistry may be heated to release the collected species, or may be dissolved to release the collected species, whereafter the collected species may be analyzed in a GC/MS. The aerogels may be used in the both low and high-volume collectors. This process allows quicker, and therefore cheaper, analysis of airborne substances.Type: ApplicationFiled: July 30, 2001Publication date: January 30, 2003Applicant: The Regents of the University of CaliforniaInventors: Fred S. Miller, Brian D. Andresen
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Publication number: 20030021733Abstract: A porous protective sheath for active extraction media used in solid phase microextraction (SPME). The sheath permits exposure of the media to the environment without the necessity of extending a fragile coated fiber from a protective tube or needle. Subsequently, the sheath can pierce and seal with GC-MS septums, allowing direct injection of samples into inlet ports of analytical equipment. Use of the porous protective sheath, within which the active extraction media is contained, mitigates the problems of: 1) fiber breakage while the fiber is extended during sampling, 2) active media coating loss caused by physical contact of the bare fiber with the sampling environment; and 3) coating slough-off during fiber extension and retraction operations caused by rubbing action between the fiber and protective needle or tube.Type: ApplicationFiled: July 27, 2001Publication date: January 30, 2003Applicant: The Regents of the University of CaliforniaInventors: Brian D. Andresen, Erik Randich
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Publication number: 20020192142Abstract: Airborne or aqueous organic compound collection using carbon nanotubes. Exposure of carbon nanotube-coated disks to controlled atmospheres of chemical warefare (CW)-related compounds provide superior extraction and retention efficiencies compared to commercially available airborne organic compound collectors. For example, the carbon nanotube-coated collectors were four (4) times more efficient toward concentrating dimethylmethyl-phosphonate (DMMP), a CW surrogate, than Carboxen, the optimized carbonized polymer for CW-related vapor collections. In addition to DMMP, the carbon nanotube-coated material possesses high collection efficiencies for the CW-related compounds diisopropylaminoethanol (DIEA), and diisopropylmethylphosphonate (DIMP).Type: ApplicationFiled: June 5, 2002Publication date: December 19, 2002Applicant: The Regents of the University of CaliforniaInventors: Thomas M. Tillotson, Brian D. Andresen, Armando Alcaraz
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Publication number: 20020150504Abstract: A field kit for the collection, isolation and concentration of trace amounts of high explosives (HE), biological weapons (BW) and chemical weapons (CW) residues in air, soil, vegetation, swipe, and liquid samples. The field kit includes a number of Solid Phase Microextraction (SPME) fiber and syringe assemblies in a hermetically sealed transportation container or tubes which includes a sampling port, a number of extra SPME fiber and syringe assemblies, the fiber and syringe assemblies including a protective cap for the fiber, and an extractor for the protective cap, along with other items including spare parts, protective glove, and an instruction manual, all located in an airtight container.Type: ApplicationFiled: April 12, 2001Publication date: October 17, 2002Applicant: The Regents of the University of CaliforniaInventors: Peter J. Nunes, Brian D. Andresen
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Publication number: 20020150513Abstract: A miniature solid phase microextraction (SPME) holder. The miniature holder enables transportation and field use of SPME fibers which are very fragile and will break with the slightest impact. Also, the holder prevents cross contamination of samples during transport. The SPME holder consists of a barrel with two end caps, and includes a plunger that is connected to a commercial SPME fiber assembly, one end cap filing over the SPME needle on one end of the barrel and the other end cap fitting over the plunger. The end caps are provided with seals that give the holder a hermetic seal. The holder enables effective field use for the collection, isolation, and concentration of trace amounts of residues air, soil, etc.Type: ApplicationFiled: April 18, 2002Publication date: October 17, 2002Applicant: The Regents of the University of CaliforniaInventors: Peter J. Nunes, Fredrick R. Kelly, Brian D. Andresen
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Patent number: 6416800Abstract: An edible fiberoptic light source is combined with confectioneries, in particular candy, to form a safe edible material possessing unusual combinations of internally generated colors and optical images. The basic design consists of a edible food pipes that may be placed within various confectioneries or foodstuffs that elicits light of various colors and intensities while standing untouched and even as the product is ingested. Digestible optical fibers act as light pipes to carry light into confectioneries where different colors and patterns of light are generated as the candy is reduced in size. Indigestible fiberoptics may see use delivering light energy into areas of digestible fiberoptic or digestible optic carriage. The light source and edible fiber optics not only has uses in candies of all types, especially lollipops and hard candy, but also is suitable for frozen food products (Popsicles), cakes and pies with lettering and decorations that emit light.Type: GrantFiled: August 4, 2000Date of Patent: July 9, 2002Assignee: Pearl Technology Holdings, LLCInventors: Paul J. Weber, Brian D. Andresen
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Patent number: 6338824Abstract: An ultratrace detector system for hand-held gas chromatography having high sensitivity, for example, to emissions generated during production of weapons, biological compounds, drugs, etc. The detector system is insensitive to water, air, helium, argon, oxygen, and CO2. The detector system is basically composed of a hand-held capillary gas chromatography (GC), an insulated heated redox-chamber, a detection chamber, and a vapor trap. For example, the detector system may use gas phase redox reactions and spectral absorption of mercury vapor. The gas chromatograph initially separates compounds that percolate through a bed of heated mercuric oxide (HgO) in a silica—or other metal—aerogel material which acts as an insulator.Type: GrantFiled: June 8, 1999Date of Patent: January 15, 2002Assignee: The Regents of the University of CaliforniaInventors: Brian D. Andresen, Fred S. Miller
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Patent number: 6126804Abstract: A new approach and instrument for field identification of micro-organisms and DNA fragments using a small and disposable device containing integrated polymerase chain reaction (PCR) enzymatic reaction wells, attached capillary electrophoresis (CE) channels, detectors, and read-out all on/in a small hand-held package. The analysis instrument may be made inexpensively, for example, of plastic, and thus is disposable, which minimizes cross contamination and the potential for false positive identification between samples. In addition, it is designed for multiple users with individual applications. The integrated PCR/CE is manufactured by the PCR well and CE channels are "stamped" into plastic depressions where conductive coatings are made in the wells and ends of the CE microchannels to carry voltage and current to heat the PCR reaction mixtures and simultaneously draw DNA bands up the CE channels.Type: GrantFiled: September 23, 1997Date of Patent: October 3, 2000Assignee: The Regents of the University of CaliforniaInventor: Brian D. Andresen
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Patent number: 5980832Abstract: An ultratrace detector system for hand-held gas chromatography having high sensitivity, for example, to emissions generated during production of weapons, biological compounds, drugs, etc. The detector system is insensitive to water, air, helium, argon, oxygen, and C0.sub.2. The detector system is basically composed of a hand-held capillary gas chromatography (GC), an insulated heated redox-chamber, a detection chamber, and a vapor trap. For example, the detector system may use gas phase redox reactions and spectral absorption of mercury vapor. The gas chromatograph initially separates compounds that percolate through a bed of heated mercuric oxide (HgO) in a silica--or other metal--aerogel material which acts as an insulator.Type: GrantFiled: September 23, 1997Date of Patent: November 9, 1999Assignee: The Regents of the University of CaliforniaInventors: Brian D. Andresen, Fred S. Miller
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Patent number: 5525799Abstract: A gas chromatograph-mass spectrometer (GC-MS) for use as a field portable organic chemical analysis instrument. The GC-MS is designed to be contained in a standard size suitcase, weighs less than 70 pounds, and requires less than 600 watts of electrical power at peak power (all systems on). The GC-MS includes: a conduction heated, forced air cooled small bore capillary gas chromatograph, a small injector assembly, a self-contained ion/sorption pump vacuum system, a hydrogen supply, a dual computer system used to control the hardware and acquire spectrum data, and operational software used to control the pumping system and the gas chromatograph. This instrument incorporates a modified commercial quadrupole mass spectrometer to achieve the instrument sensitivity and mass resolution characteristic of laboratory bench top units.Type: GrantFiled: April 8, 1994Date of Patent: June 11, 1996Assignee: The United States of America as represented by the United States Department of EnergyInventors: Brian D. Andresen, Joel D. Eckels, James F. Kimmons, David W. Myers
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Patent number: 5153433Abstract: A portable mass spectrometer is described having one or more electrostatic focusing sectors and a magnetic focusing sector, all of which are positioned inside a vacuum chamber, and all of which may be adjusted via adjustment means accessible from outside the vacuum chamber. Mounting of the magnetic sector entirely within the vacuum chamber permits smaller magnets to be used, thus permitting reductions in both weight and bulk.Type: GrantFiled: September 10, 1991Date of Patent: October 6, 1992Assignee: The United States of America as represented by the United States Department of EnergyInventors: Brian D. Andresen, Joel D. Eckels, James F. Kimmons, Walter H. Martin, David W. Myers, Robert F. Keville